Microbiology Quiz: Neisseria Species

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Questions and Answers

Which species of Neisseria is linked to meningitis?

  • Neisseria meningitidis (correct)
  • Neisseria gonorrhoeae
  • Neisseria lactamica
  • Neisseria sicca

What type of organism is Neisseria gonorrhoeae?

  • Gram-positive coccus
  • Gram-positive bacillus
  • Gram-negative spirillum
  • Gram-negative cocci (correct)

How is Neisseria gonorrhoeae primarily transmitted?

  • Airborne droplets
  • Sexual contact (correct)
  • Insect bites
  • Contaminated food

Which of the following best describes the morphology of Neisseria species?

<p>Non-motile diplococci (D)</p> Signup and view all the answers

What condition is primarily caused by Neisseria gonorrhoeae?

<p>Gonorrhea (A)</p> Signup and view all the answers

What is the common appearance of Neisseria species under the microscope?

<p>Diplococci (B)</p> Signup and view all the answers

What type of bacteria is Neisseria classified as?

<p>Aerobic (C)</p> Signup and view all the answers

Which of the following is a common characteristic of Neisseria gonorrhoeae in clinical samples?

<p>Presence in polymorphonuclear leukocytes (A)</p> Signup and view all the answers

What is the primary reason why the organism cannot survive long outside the human body?

<p>It is highly sensitive to dehydration. (B)</p> Signup and view all the answers

Which symptom is most commonly associated with a gonococcal infection in females?

<p>Greenish-yellow cervical discharge. (A)</p> Signup and view all the answers

What complication is associated with untreated gonococcal salpingitis in women?

<p>Infertility due to tubal scarring. (A)</p> Signup and view all the answers

Ophthalmia neonatorum can be treated effectively with which antibiotic?

<p>Erythromycin. (D)</p> Signup and view all the answers

Which of the following describes a potential outcome of infection with N. meningitidis?

<p>Fulminant meningococcemia without meningitis. (B)</p> Signup and view all the answers

What population is at higher risk for outbreaks of meningitis caused by N. meningitidis?

<p>People in crowded environments like schools and military barracks. (A)</p> Signup and view all the answers

Which of the following conditions may follow acute conjunctivitis if left untreated?

<p>Permanent blindness. (D)</p> Signup and view all the answers

Which symptom is associated with both males and females suffering from gonococcal infections?

<p>Pain during urination. (D)</p> Signup and view all the answers

What is the most important virulence factor of N.meningitidis?

<p>Polysaccharide capsule (D)</p> Signup and view all the answers

Which group does the conjugate meningococcal vaccine (MCV4) target?

<p>Adolescents and adults aged 11 to 55 years (B)</p> Signup and view all the answers

What symptoms are characteristic of meningitis caused by N.meningitidis?

<p>Severe headache and rigid neck (A)</p> Signup and view all the answers

N.meningitidis initially colonizes which part of the body?

<p>Nasopharynx (C)</p> Signup and view all the answers

What type of vaccine is Bexsero®?

<p>Serogroup B meningococcal vaccine (C)</p> Signup and view all the answers

What can occur within several hours after the onset of symptoms in a meningococcal infection?

<p>Coma (B)</p> Signup and view all the answers

Which of the following is NOT a serogroup included in the MCV4 vaccine?

<p>Serogroup B (A)</p> Signup and view all the answers

Acute, fulminating meningococcal septicemia occurs mainly in which population?

<p>Very young children (D)</p> Signup and view all the answers

Which genera are primarily associated with gastrointestinal diseases?

<p>Escherichia (B)</p> Signup and view all the answers

What characteristic do members of the genus Acinetobacter possess?

<p>Nonmotile coccobacilli (B)</p> Signup and view all the answers

What is the role of fimbriae or pili in E. coli?

<p>Adherence to mucosal surfaces (B)</p> Signup and view all the answers

Which of the following pathogens is described as an opportunistic pathogen?

<p>E. coli (B)</p> Signup and view all the answers

What distinguishes the transmission of organisms causing GI diseases?

<p>Fecal contamination (C)</p> Signup and view all the answers

Which organisms primarily cause extraintestinal diseases?

<p>Klebsiella and Proteus (A)</p> Signup and view all the answers

What type of bacteria are found in the gastrointestinal tract of humans or animals?

<p>Facultative anaerobes (D)</p> Signup and view all the answers

Which statement about lipopolysaccharide (LPS) is true?

<p>It acts as an endotoxin (C)</p> Signup and view all the answers

What is a major cause of neonatal meningitis within the first month of life?

<p>E.coli (D)</p> Signup and view all the answers

What condition is primarily caused by serotype Typhi of Salmonella?

<p>Typhoid fever (D)</p> Signup and view all the answers

Which symptom is NOT commonly associated with salmonella gastroenteritis?

<p>Constipation (A)</p> Signup and view all the answers

Which species is known for causing shigellosis?

<p>Shigella (B)</p> Signup and view all the answers

What is a common non-specific symptom associated with enteric (typhoid) fever?

<p>Chills (B)</p> Signup and view all the answers

What can Campylobacter infections lead to in otherwise healthy individuals?

<p>Acute enteritis (A)</p> Signup and view all the answers

What characteristic does the Shiga toxin possess?

<p>Both enterotoxic and cytotoxic properties (C)</p> Signup and view all the answers

What type of lesions can Campylobacter cause in the intestines?

<p>Ulcerative, inflammatory lesions (B)</p> Signup and view all the answers

Which type of E.coli is primarily associated with traveler's diarrhea?

<p>Enterotoxigenic E.coli (ETEC) (D)</p> Signup and view all the answers

What primarily differentiates Enterohemorrhagic E.coli (EHEC) from other types of E.coli?

<p>Produces an exotoxin causing bloody diarrhea (B)</p> Signup and view all the answers

Which strain of E.coli is most commonly associated with severe complications such as hemolytic uremic syndrome (HUS)?

<p>O157:H7 (A)</p> Signup and view all the answers

In which population is Enteropathogenic E.coli (EPEC) particularly significant as a cause of diarrhea?

<p>Infants in areas with poor sanitation (A)</p> Signup and view all the answers

What type of disease is Enteroinvasive E.coli (EIEC) known to cause?

<p>Dysentery-like syndrome (B)</p> Signup and view all the answers

What is the most common source of extraintestinal E.coli infections?

<p>Patient's own nonpathogenic flora (A)</p> Signup and view all the answers

Which E.coli type causes persistent diarrhea in young children?

<p>Enteroadherent E.coli (EAEC) (D)</p> Signup and view all the answers

Why are women particularly at risk for urinary tract infections (UTIs) caused by E.coli?

<p>Shorter urethra (C)</p> Signup and view all the answers

Flashcards

Gram-negative cocci

Gram-negative bacteria shaped like spheres.

Neisseria

A genus of gram-negative, aerobic cocci bacteria.

Neisseria gonorrhoeae

A pathogenic Neisseria species causing gonorrhea.

Neisseria meningitidis

A pathogenic Neisseria species causing meningitis.

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Gonorrhea

Sexually transmitted infection caused by N. gonorrhoeae.

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Gram-negative rods

Gram-negative bacteria shaped like rods.

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Aerobic bacteria

Bacteria needing oxygen for growth.

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Anaerobic bacteria

Bacteria that don't need oxygen for growth.

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Gonococcal infection symptoms (males)

Acute infection characterized by yellow, purulent urethral discharge and painful urination.

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Gonococcal infection symptoms (females)

Symptoms include greenish-yellow cervical discharge and possible intermenstrual bleeding, progressing to potential salpingitis, PID, and fibrosis.

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Ophthalmia neonatorum

Gonococcal infection of the newborn's conjunctiva acquired during childbirth.

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N. meningitidis infection

Frequent cause of meningitis, potentially leading to meningococcemia with shock.

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Pili role

Pili enhance attachment to host epithelial and mucosal cells.

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Meningitis outbreaks

Occur frequently in winter/early spring due to close contact; also occur in developing nations.

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Gonococcal infection consequences (females)

Can lead to infertility due to tubal scarring from salpingitis and PID.

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Bacterial sensitivity to dehydration

Bacteria, like gonococcus, are highly sensitive to dehydration, so they don't survive long outside the human body.

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Meningococcus

The bacterium Neisseria meningitidis, responsible for causing meningitis and septicemia.

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Meningococcal Meningitis

A serious infection of the meninges, the membranes surrounding the brain and spinal cord, caused by Neisseria meningitidis.

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Meningococcal Septicemia

A life-threatening blood infection caused by Neisseria meningitidis, leading to rapid bacterial multiplication in the bloodstream.

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Antiphagocytic Capsule

The outer layer of Neisseria meningitidis that prevents it from being engulfed and destroyed by immune cells (phagocytes).

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Meningococcemia

The presence of Neisseria meningitidis in the bloodstream, a stage leading to meningococcal meningitis or septicemia.

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Fulminating Septicemia

A rapidly progressing and severe form of septicemia, often fatal if untreated.

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Meningococcal Vaccine (MCV4)

A vaccine containing capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y, protecting against these specific strains.

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MenACWY Vaccine

A type of meningococcal conjugate vaccine that protects against serogroups A, C, W-135, and Y.

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Moraxella

A bacterial genus known for causing infections in various parts of the body, including the respiratory system, middle ear, eyes, central nervous system, and joints.

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Acinetobacter

A genus of non-motile, coccobacillus bacteria that are often responsible for hospital-acquired infections (nosocomial infections).

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Gram-negative Rods in the GI Tract

A group of bacteria found in the gastrointestinal tract of humans and animals. These bacteria are facultative anaerobes, meaning they can grow in the presence or absence of oxygen. They contain lipopolysaccharide (LPS), also known as endotoxin.

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Enterobacteriaceae

A family of gram-negative, facultative anaerobic bacteria that includes both pathogenic and non-pathogenic species. They are commonly found in the intestines of humans and animals.

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Salmonella

A genus of bacteria that commonly causes infections in the gastrointestinal tract, leading to food poisoning and other illnesses.

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Escherichia coli (E. coli)

A type of bacteria that normally resides in the colon but can cause various infections both within and outside the gastrointestinal tract. It is known for its fimbriae (pili) used for attaching to host mucosal surfaces.

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Opportunistic Pathogen

A microorganism that causes disease only under specific conditions, such as a weakened immune system or when introduced to a normally sterile body site.

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Fimbriae/Pili

Hair-like structures on the surface of some bacteria that help them attach to host cells, often contributing to the development of infections.

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ETEC

Enterotoxigenic E. coli, a common cause of traveler's diarrhea, spreading through contaminated food, water, or person-to-person contact.

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EPEC

Enteropathogenic E. coli, a significant cause of diarrhea in infants, especially in areas with inadequate sanitation.

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EHEC

Enterohemorrhagic E. coli, producing verotoxin (Shiga-like toxin) leading to bloody diarrhea (hemorrhagic colitis) and potentially life-threatening kidney failure (HUS).

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E. coli Strain O104:H4

A particularly dangerous E. coli strain combining features of EAEC and EHEC, leading to severe complications.

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EIEC

Enteroinvasive E. coli, causing dysentery-like symptoms like fever and bloody stools.

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EAEC

Enteroaggregative E. coli, causing traveler's diarrhea and persistent diarrhea in young children.

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E. coli UTI

E. coli is a primary cause of urinary tract infections (UTIs), including cystitis and pyelonephritis, with women being particularly susceptible.

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Extraintestinal E. coli Infection

E. coli can cause disease in sterile sites like the bladder or bloodstream, even if it's normally harmless in the intestines.

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Neonatal meningitis

A severe infection of the membranes surrounding the brain and spinal cord, affecting newborns within the first month of life. E. coli is a major cause.

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Nosocomial infection

An infection acquired during a hospital stay, often from exposure to pathogens in the hospital environment.

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Salmonella infection

A bacterial infection that can cause both intestinal and extraintestinal diseases, including gastroenteritis and typhoid fever.

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Typhoid fever

A severe and life-threatening systemic illness caused by Salmonella Typhi, characterized by high fever, abdominal symptoms, and potential complications.

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Neonatal Meningitis Cause

E. coli is a major cause of meningitis in infants within the first month of life.

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Salmonella: Diseases Caused

Salmonella can cause a range of illnesses including gastroenteritis (food poisoning) and typhoid fever.

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Gastroenteritis Symptoms

Symptoms include nausea, vomiting, diarrhea, fever, and abdominal cramping.

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Typhoid Fever Symptoms

A serious illness with fever, abdominal pain, and potentially a rash. Primarily caused by S. Typhi.

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Campylobacter: What's special?

These bacteria are curved or S-shaped and can cause infections in the intestines.

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Shigellosis: Who's at risk?

Shigella causes bacillary dysentery, a human intestinal disease common among young children.

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Vibrio: Shape

Vibrio bacteria are short, curved, and rod-shaped.

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Study Notes

Gram-Negative Bacteria

  • Gram-negative bacteria are a diverse group of organisms, common in the gastrointestinal tract of animals, and sometimes pathogenic in humans.
  • Many gram-negative bacteria are aerobic, some are facultative anaerobes.
  • Important genera include: Neisseria, Moraxella, Haemophilus, Bordetella, Brucella, Enteric bacteria (e.g., Escherichia, Salmonella, Shigella, etc.), Campylobacter, Vibrio, Helicobacter, Legionella, Pseudomonas, Acinetobacter, Bacteroides, and Francisella.
  • These bacteria can be categorized as cocci, coccobacilli, or rods (bacilli - both straight and curved).
  • Various gram-negative bacteria cause diseases of the respiratory, gastrointestinal, genitourinary and other systems and can potentially cause a life-threatening condition.
  • Some are important nosocomial (hospital-acquired) pathogens.

Gram-Negative Cocci

  • Members of Neisseria are nonmotile, gram-negative cocci, often found in pairs (diplococci)
  • Neisseria gonorrhoeae (gonococcus): sexually transmitted, causes gonorrhea
  • Neisseria meningitidis (meningococcus): causes meningitis
  • Both are nonmotile diplococci, and indistinguishable microscopically

Gram-Negative Rods (Bacilli)

  • Key rod-shaped gram-negative bacteria categorized in different types based on their characteristics:
  • Respiratory organisms: Haemophilus, Bordetella, Legionella
  • Zoonotic organisms: Brucella, Francisella, Pasteurella, Yersinia
  • Enteric and related organisms: Escherichia, Enterobacter, Serratia, Salmonella etc.
  • Curved rods (also called Vibrios): Vibrio

Other Gram-Negative Bacteria

  • Campylobacter: curved bacteria, cause enteritis
  • Shigella: causes shigellosis, usually among young children.
  • Helicobacter pylori: causes acute gastritis as well as duodenal and gastric ulcers.

Specific Diseases

  • Ophthalmia neonatorum: conjunctival sac infection acquired from the mother during birth canal passage; can lead to blindness
  • Meningitis: inflammation of meninges; Neisseria meningitidis is a frequent cause, often resulting in a sudden onset and potentially life-threatening
  • Septicemia: presence of pathogenic microorganisms in the blood, often causing fatal consequences, caused by Neisseria meningitidis.
  • Urinary tract infection (UTI): E. coli is a leading cause of UTIs, including cystitis and pyelonephritis.
  • Gastroenteritis (intestinal infections): different types of E. coli cause different forms of diarrhea, both in the gastrointestinal tract and outside of it.

Vaccination

  • Meningococcal conjugate vaccine (MCV4) and serogroup B meningococcal vaccines are available to prevent the disease.

Treatment and Clinical Significance

  • Specific antibiotics are used to treat gram-negative bacterial infections, depending on the specific organism involved.
  • Many gram-negative bacteria cause life-threatening disease.
  • Treatment is frequently important and crucial to treat patients with diseases caused by gram-negative bacteria.

Important Note: This information is for study purposes only. Consult healthcare professionals for accurate and timely medical advice. Always follow professional medical guidelines.

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