Blood Flagellates
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Questions and Answers

What is characteristic of the kinetoplast in blood and tissue flagellates?

  • It consists of a parabasal body and an adjacent dotlike blepharoplast (correct)
  • It consists of a single nucleus and a kinetoplast
  • It consists of a parabasal body and a distinct flagellum
  • It consists of a flagellum and a blepharoplast

What is the primary mode of transmission of Leishmaniasis?

  • The bite of certain types of sandflies (correct)
  • Airborne transmission
  • Direct contact with infected animals
  • Contaminated food and water

Which of the following is a risk factor for Leishmaniasis?

  • Proper sanitation and hygiene
  • Malnutrition and poverty
  • Urbanization and deforestation
  • All of the above, except proper sanitation and hygiene (correct)

What is the shape of the amastigote form of Leishmania?

<p>Spherical or subspherical (A)</p> Signup and view all the answers

Which genus of sandflies transmits Old World Leishmaniasis?

<p>Phlebotomus (D)</p> Signup and view all the answers

How many hosts are necessary for the life cycle of Leishmania?

<p>Two hosts, humans and sandflies (A)</p> Signup and view all the answers

What is the form of Leishmania that is found extracellularly in the alimentary canal of the sand fly?

<p>Promastigote (C)</p> Signup and view all the answers

Where do promastigotes initially migrate to after reproduction in the sand fly?

<p>Proximal end of the gut (D)</p> Signup and view all the answers

What is the result of repeated multiplication of amastigotes in the macrophage cell?

<p>The macrophage cell breaks down due to pressure of mass (A)</p> Signup and view all the answers

How do amastigotes typically spread to new hosts in the human body?

<p>Both A and B (A)</p> Signup and view all the answers

What is the term for the type of leishmaniasis caused by L. tropica, L. major, and L. aethiopica?

<p>Old world leishmaniasis (D)</p> Signup and view all the answers

What is the site where promastigotes are introduced locally into the human host during a sand fly bite?

<p>Bite site (B)</p> Signup and view all the answers

What is the primary method of diagnosis for Old World leishmaniasis?

<p>A skin scraping with microscopic analysis using Wright or Giemsa stain (B)</p> Signup and view all the answers

Which type of leishmaniasis is associated with high fatality and is considered the most severe form?

<p>Visceral leishmaniasis (kala-azar) (D)</p> Signup and view all the answers

What is the habitat of the parasite Leishmania donovani in humans?

<p>Reticuloendothelial cells (A)</p> Signup and view all the answers

What is the result of a Leishmanin skin test (Montenegro test)?

<p>A delayed-type hypersensitivity reaction (D)</p> Signup and view all the answers

What is the typical outcome of cutaneous leishmaniasis?

<p>The lesion heals in a few months to a year, leaving an unpleasant-looking scar (C)</p> Signup and view all the answers

What is the outcome of diffuse cutaneous leishmaniasis?

<p>The lesion produces widespread skin lesions that resemble leprosy (B)</p> Signup and view all the answers

What is the primary site of Leishmania replication in the human body?

<p>Macrophages (A)</p> Signup and view all the answers

What is the outcome of severe cases of mucocutaneous leishmaniasis if left untreated?

<p>Difficulty eating and potentially fatal (A)</p> Signup and view all the answers

What is the primary goal of vaccination against Leishmania?

<p>To stimulate a strong cell-mediated immunity (A)</p> Signup and view all the answers

Which of the following is a treatment option for visceral leishmaniasis?

<p>Liposomal amphotericin B (D)</p> Signup and view all the answers

What is the advantage of treating people with leishmaniasis early?

<p>To prevent further spread of the disease (A)</p> Signup and view all the answers

What is the typical outcome of a mucocutaneous leishmaniasis lesion if left untreated?

<p>The lesion will spontaneously heal with scarring (A)</p> Signup and view all the answers

What is the primary location where the parasite multiplies after inoculation?

<p>Reticuloendothelial cells (B)</p> Signup and view all the answers

Which of the following is a common symptom of Old World Leishmaniasis?

<p>Enlargement of the spleen (C)</p> Signup and view all the answers

What is the usual cause of death in patients with Old World Leishmaniasis?

<p>Secondary infections (A)</p> Signup and view all the answers

What is the name of the secondary form of the disease that may occur after successful treatment?

<p>Post kala-azar dermal leishmaniasis (B)</p> Signup and view all the answers

Which of the following is a parasitological diagnosis method for Old World Leishmaniasis?

<p>Blood film stained with Leishman or Giemsa stain (A)</p> Signup and view all the answers

What is the purpose of PCR tests in the diagnosis of Old World Leishmaniasis?

<p>To detect Leishmania DNA (D)</p> Signup and view all the answers

What is the primary reason why most vaccines against Leishmania have been ineffective?

<p>They induce a humoral response instead of a cell-mediated response (D)</p> Signup and view all the answers

Which of the following is a characteristic of the pathogenesis of mucocutaneous leishmaniasis?

<p>Leishmania invades human macrophages and replicates intracellularly (B)</p> Signup and view all the answers

What is the primary factor that determines the treatment of leishmaniasis?

<p>The species of Leishmania involved (A)</p> Signup and view all the answers

What is the purpose of reservoir control programs in the prevention of leishmaniasis?

<p>To reduce the number of animals that serve as reservoirs for Leishmania (B)</p> Signup and view all the answers

What is the outcome of severe cases of mucocutaneous leishmaniasis if left untreated?

<p>The disease can be fatal and can diminish the ability to eat (D)</p> Signup and view all the answers

What is the role of macrophages in the pathogenesis of leishmaniasis?

<p>They are the primary host cells for Leishmania replication (B)</p> Signup and view all the answers

What is the primary mechanism of transmission of Leishmania?

<p>Sandfly bites (A)</p> Signup and view all the answers

What is the effect of leishmaniasis on the nose and mouth?

<p>It causes both skin and mucosal ulcers (D)</p> Signup and view all the answers

What is the primary goal of preventive measures against leishmaniasis?

<p>To reduce the risk of transmission to humans (D)</p> Signup and view all the answers

What is the characteristic of the lesions that develop at the site of the sandfly bite in mucocutaneous leishmaniasis?

<p>They may spontaneously heal with scarring (B)</p> Signup and view all the answers
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