Microbiology and Biochemistry - Body Defense
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Questions and Answers

Which of the following is NOT considered a component of the body's first line of defense?

  • Hairs
  • Phagocytes (correct)
  • Mucous membranes
  • Skin
  • Adaptive defenses protect the body against all microorganisms regardless of prior exposure.

    False (B)

    What is the primary function of lysozyme in body defense?

    to break down bacterial cell walls

    The acidic film formed by ______ over the skin surface inhibits microbial growth.

    <p>sebum</p> Signup and view all the answers

    Match the following body defense mechanisms with their description:

    <p>Skin = Physical barrier to microbial entrance Mucous membranes = Inhibit entrance of many microbes Gastric juice = Destroys most bacteria and toxins in the stomach Lysozyme = Antimicrobial substance that breaks down bacterial cell walls</p> Signup and view all the answers

    Which of these is a mechanical protection mechanism of the first line of defense?

    <p>Flow of urine (C)</p> Signup and view all the answers

    Fever is a component of the first line of non-specific defense.

    <p>False (B)</p> Signup and view all the answers

    Name two ways the body expels toxins and microbes.

    <p>defecation and vomiting</p> Signup and view all the answers

    Which of the following is NOT a component of the second line of defense?

    <p>Skin (A)</p> Signup and view all the answers

    Phagocytosis is the process where microbes are ingested and destroyed by phagocytes.

    <p>True (A)</p> Signup and view all the answers

    What are the two main types of phagocytes mentioned?

    <p>neutrophils and macrophages</p> Signup and view all the answers

    During phagocytosis, the phagocyte extends structures called _________ to surround the bacteria.

    <p>pseudopods</p> Signup and view all the answers

    Which type of phagocyte is known as a 'big eater' and is long lived?

    <p>Macrophages (C)</p> Signup and view all the answers

    Neutrophils are long-lived phagocytes that remain in tissues for extended periods.

    <p>False (B)</p> Signup and view all the answers

    Match the following phagocyte cells with their function:

    <p>Macrophages = Engulf and destroy microbes and cellular debris Eosinophils = Secrete enzymes to kill parasitic worms Basophils = Involved in allergic responses Mast cells = Cause vasodilatation of blood vessels near wounds</p> Signup and view all the answers

    What is the first step in phagocytosis?

    <p>Chemotaxis (A)</p> Signup and view all the answers

    What is the process where phagocytes move to an injured area?

    <p>Chemotaxis (C)</p> Signup and view all the answers

    Natural killer cells have membrane molecules that identify T and B cells.

    <p>False (B)</p> Signup and view all the answers

    What is the name of the protein produced by cells infected with viruses that inhibits viral replication?

    <p>interferon</p> Signup and view all the answers

    The process where a phagocyte engulfs a microbe is called ______.

    <p>ingestion</p> Signup and view all the answers

    Match the following inflammatory symptoms with their descriptions:

    <p>Redness = Increased blood flow to the area Heat = Increased temperature due to blood flow Swelling = Accumulation of fluid in the tissue Pain = Stimulation of nerve endings</p> Signup and view all the answers

    What is the function of antimicrobial proteins?

    <p>To attract dendritic and mast cells and produce antimicrobial activity (A)</p> Signup and view all the answers

    Pus consists only of dead phagocytes.

    <p>False (B)</p> Signup and view all the answers

    What are the cells that are first to arrive at the site of injury during inflammation?

    <p>neutrophils</p> Signup and view all the answers

    The process where leukocytes squeeze through blood vessel walls is called ______.

    <p>emigration/diapedesis</p> Signup and view all the answers

    Which of the following is NOT a function of inflammation?

    <p>Cause fever (B)</p> Signup and view all the answers

    Fever inhibits the activity of phagocytes.

    <p>False (B)</p> Signup and view all the answers

    What are the proteins released by NK cells that create pores in the plasma membrane of a microbe?

    <p>perforins</p> Signup and view all the answers

    The increased blood flow during inflammation, which leads to redness and heat, is known as ______.

    <p>hyperemia</p> Signup and view all the answers

    Match the following chemical mediators with their functions:

    <p>Histamines = Stimulate vasodilation and increase permeability of blood vessels Kinins = Stimulate nerve endings, causing pain Prostaglandins = Stimulate production of other inflammatory mediators Leukotrienes = Attract and stimulate phagocytes</p> Signup and view all the answers

    Which of the following is a positive effect of fever?

    <p>Inhibition of microbial growth (D)</p> Signup and view all the answers

    Flashcards

    First Line Defense

    The body's first line of defense against infection, providing a physical barrier to prevent the entry of microorganisms.

    Epidermis

    Refers to the outer layer of skin, acting as a physical barrier against microbes.

    Mucous Membranes

    Protective layers found in various body openings, such as the nose, mouth, and intestines, trapping and inhibiting microbes.

    Sebum

    A type of chemical protection that forms an acidic film on the skin, inhibiting the growth of many microbes.

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    Lysozyme

    A natural enzyme present in various body fluids, such as tears and saliva, that breaks down bacterial cell walls, weakening them.

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    Second Line Defense

    The body's second line of defense against infection, involving a range of mechanisms that attack invaders once they have entered the body.

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    Phagocytes

    Specialized cells that engulf and destroy invading microorganisms.

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    Natural Killer Cells

    A type of white blood cell that helps to kill infected cells and other harmful cells in the body.

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    Second Line of Defense

    The second line of defense in the immune system that attacks any microbes that have survived the first line of defense. It involves phagocytes, natural killer cells, antimicrobial proteins, inflammation, and fever.

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    Phagocytosis

    The process of ingestion and destruction of microbes or any foreign particulate matter by phagocytes.

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    Macrophage

    A type of phagocyte that is long-lived and matures from monocytes. It leaves the bloodstream, enters tissue, and develops into macrophages. They can be wondering (migrating) or fixed (stationary) in specific organs.

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    Neutrophil

    A type of phagocyte that is short-lived and phagocytizes bacteria. They enter tissue and live for a few hours only.

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    Eosinophil

    A type of phagocyte that secretes enzymes to kill parasitic worms.

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    Basophil

    A type of phagocyte that contains granules of toxic chemicals that can digest foreign microorganisms. They are involved in allergic responses.

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    Mast Cell

    Cells that contain inflammatory chemicals such as histamine and serotonin, causing vasodilation near wounds.

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    What is apoptosis?

    Apoptosis is a programmed cell death where a cell self-destructs in a controlled manner. It's a normal process, not a harmful one.

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    What is phagocytosis?

    Phagocytosis is a process where a phagocyte engulfs and destroys harmful invaders like bacteria.

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    What is Chemotaxis?

    Chemotaxis is the movement of phagocytes towards the source of a chemical signal, like a chemical beacon attracting them.

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    In phagocytosis, what is adherence?

    Adherence is the step where the phagocyte attaches itself to the target microbe, like a sticky note.

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    In phagocytosis, what is ingestion?

    Ingestion is the process where the phagocyte engulfs the microbe, like swallowing it whole.

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    In phagocytosis, what is digestion?

    Digestion is the breakdown of the microbe inside a phagolysosome, like a digestive vat.

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    In phagocytosis, what is killing?

    Killing is the final step where the microbe is destroyed, but the phagocyte also dies in the process, sacrificing itself.

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    What is Pus?

    Pus is a collection of dead phagocytes, damaged tissue, and fluid, which forms when the immune system fights infections.

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    What are Natural Killer cells?

    Natural Killer cells are lymphocytes that lack the usual identifiers of T and B cells. They kill infected cells and tumor cells.

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    What are Perforins?

    Perforins are proteins released by NK cells that create holes in the plasma membrane of infected or tumor cells, causing them to die.

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    What are Interferons?

    Interferons are proteins released by infected cells that alert nearby cells to produce antiviral proteins to fight the infection.

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    What is the Complement system?

    Complement is a group of proteins in blood plasma that enhance the immune response, stimulate inflammation, and directly kill some microbes.

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    What are Iron-binding proteins?

    Iron-binding proteins are proteins that bind to iron in body fluids, making it unavailable for microbial growth.

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    What is Inflammation?

    Inflammation is a complex response to tissue damage, involving redness, heat, swelling, and pain. It's the body's way of isolating and fighting invaders.

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    What is Vasodilation?

    Vasodilation is the widening of blood vessels, increasing blood flow to the injured area, causing redness and heat.

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    Study Notes

    Microbiology and Biochemistry - Body Defense (Non-Specific)

    • The body has innate (non-specific) and adaptive (specific) defenses against infection.

    • Innate defenses target all microorganisms, while adaptive defenses target specific pathogens.

    • First line defense is a mechanical and chemical barrier.

      • Mechanical protection: Skin (epidermis), mucous membranes, hairs, and mucus trap and filter microbes, dust, and pollutants. Tears, saliva, and urine wash microbes away.
      • Chemical protection: Sebum, perspiration, lysozyme, gastric juice (low pH), and vaginal secretions inhibit microbial growth.
    • Second line defense:

      • Phagocytes: Large white blood cells that engulf and destroy microbes and debris. Types include neutrophils, macrophages, monocytes, basophils, eosinophils, and mast cells. -neutrophils: phagocytize bacteria, and short lived. After entering tissue, neutrophils will liv eonly in few hours. -eosinopils: secrete enzymes to kill parasitic worms. -basophils: contain granules of toxic chemicals that can digest foreign microorganisms. These are cells involved in allergic response. -basophils: contain granules of toxic chemicals that can digest foreign microorganisms. These are cells involved in an allergic response. -*mast cell: contain variety of inflammatory chemicals including histamine and serotonin. Cause vasodilatation of blood vessels near wound. -macrophage is a big eater come from matured monocytes, consist of 2 which are fixed macrophage and wondering macrophage.
    • wondering macrophage: migrate to the tissues in search and destroying microbes and cellular debris -fixed macrophage: a permanent resident of the specific organ in the body. -process of macrophage attacking the body: macrophage will attack microbe in the body, then engulfs the microbe and displays some parts on its surface. After that, the immune response will initiated. Proteins are then secreted and body temperature wil rise. Monocytes will begin maturing into macrophage back. - Phagocytosis is a process of ingestion, destruction, and killing of microbes or foreign particles. The process involves: chemotaxis, adherence, ingestion, digestion, and killing of the microbe. Dead phagocytes and cellular debris form pus. -apoptosis: a process of a death of a cell.

      • Natural Killer (NK) cells: Lymphocytes capable of killing a wide range of microbes and tumor cells. They release perforins that damage the target cell membrane, causing cytolysis. Found in lymph nodes, spleen, and bone marrow.
      • Antimicrobial proteins: Proteins such as interferon, complement, and iron-binding proteins that enhance immune response, inhibit microbial growth, and attract immune cells.
      • Inflammation: A defensive response to tissue damage, caused by microbes, physical agents, or chemical agents. Inflammation aims to dispose of microbes, toxins, and foreign material; prevent spreading; prepare the site for repair; and restore tissue homeostasis.
        • Symptoms include redness, heat, swelling, pain, and loss of function (depending on injury site). Stages include vasodilation, increased permeability (edema), and phagocyte mobilization (chemotaxis, emigration/diapedesis)
        • Symptoms of vasodilation: Increased blood flow (hyperemia), removal of toxins/dead cells, increased oxygen/nutrients delivery.
    • Fever: An increase in body temperature caused by infection from bacteria or viruses. It increases body metabolic rate, speeds up immune defenses and tissue repair, and increases the effects of antimicrobial substances. High body temp can inhibit microbial growth and stimulate activity of phagocytes.

    Summary of Second Line of Defense

    • While powerful, second-line defense isn't perfect. Some pathogens will survive the attack.
    • Second-line defense doesn't have memory, unlike adaptive immunity. This is why a third line of defense is necessary.

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    Topic 7.1 Non-specific (PDF)

    Description

    Explore the mechanisms of the body's innate (non-specific) and adaptive (specific) defenses against infections. Learn about the first and second lines of defense, including mechanical barriers like skin and chemical agents that inhibit microbial growth. Understand the role of phagocytes in the immune response.

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