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Which of the following is NOT considered a component of the body's first line of defense?
Which of the following is NOT considered a component of the body's first line of defense?
Adaptive defenses protect the body against all microorganisms regardless of prior exposure.
Adaptive defenses protect the body against all microorganisms regardless of prior exposure.
False (B)
What is the primary function of lysozyme in body defense?
What is the primary function of lysozyme in body defense?
to break down bacterial cell walls
The acidic film formed by ______ over the skin surface inhibits microbial growth.
The acidic film formed by ______ over the skin surface inhibits microbial growth.
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Match the following body defense mechanisms with their description:
Match the following body defense mechanisms with their description:
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Which of these is a mechanical protection mechanism of the first line of defense?
Which of these is a mechanical protection mechanism of the first line of defense?
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Fever is a component of the first line of non-specific defense.
Fever is a component of the first line of non-specific defense.
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Name two ways the body expels toxins and microbes.
Name two ways the body expels toxins and microbes.
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Which of the following is NOT a component of the second line of defense?
Which of the following is NOT a component of the second line of defense?
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Phagocytosis is the process where microbes are ingested and destroyed by phagocytes.
Phagocytosis is the process where microbes are ingested and destroyed by phagocytes.
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What are the two main types of phagocytes mentioned?
What are the two main types of phagocytes mentioned?
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During phagocytosis, the phagocyte extends structures called _________ to surround the bacteria.
During phagocytosis, the phagocyte extends structures called _________ to surround the bacteria.
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Which type of phagocyte is known as a 'big eater' and is long lived?
Which type of phagocyte is known as a 'big eater' and is long lived?
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Neutrophils are long-lived phagocytes that remain in tissues for extended periods.
Neutrophils are long-lived phagocytes that remain in tissues for extended periods.
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Match the following phagocyte cells with their function:
Match the following phagocyte cells with their function:
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What is the first step in phagocytosis?
What is the first step in phagocytosis?
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What is the process where phagocytes move to an injured area?
What is the process where phagocytes move to an injured area?
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Natural killer cells have membrane molecules that identify T and B cells.
Natural killer cells have membrane molecules that identify T and B cells.
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What is the name of the protein produced by cells infected with viruses that inhibits viral replication?
What is the name of the protein produced by cells infected with viruses that inhibits viral replication?
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The process where a phagocyte engulfs a microbe is called ______.
The process where a phagocyte engulfs a microbe is called ______.
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Match the following inflammatory symptoms with their descriptions:
Match the following inflammatory symptoms with their descriptions:
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What is the function of antimicrobial proteins?
What is the function of antimicrobial proteins?
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Pus consists only of dead phagocytes.
Pus consists only of dead phagocytes.
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What are the cells that are first to arrive at the site of injury during inflammation?
What are the cells that are first to arrive at the site of injury during inflammation?
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The process where leukocytes squeeze through blood vessel walls is called ______.
The process where leukocytes squeeze through blood vessel walls is called ______.
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Which of the following is NOT a function of inflammation?
Which of the following is NOT a function of inflammation?
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Fever inhibits the activity of phagocytes.
Fever inhibits the activity of phagocytes.
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What are the proteins released by NK cells that create pores in the plasma membrane of a microbe?
What are the proteins released by NK cells that create pores in the plasma membrane of a microbe?
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The increased blood flow during inflammation, which leads to redness and heat, is known as ______.
The increased blood flow during inflammation, which leads to redness and heat, is known as ______.
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Match the following chemical mediators with their functions:
Match the following chemical mediators with their functions:
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Which of the following is a positive effect of fever?
Which of the following is a positive effect of fever?
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Flashcards
First Line Defense
First Line Defense
The body's first line of defense against infection, providing a physical barrier to prevent the entry of microorganisms.
Epidermis
Epidermis
Refers to the outer layer of skin, acting as a physical barrier against microbes.
Mucous Membranes
Mucous Membranes
Protective layers found in various body openings, such as the nose, mouth, and intestines, trapping and inhibiting microbes.
Sebum
Sebum
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Lysozyme
Lysozyme
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Second Line Defense
Second Line Defense
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Phagocytes
Phagocytes
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Natural Killer Cells
Natural Killer Cells
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Second Line of Defense
Second Line of Defense
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Phagocytosis
Phagocytosis
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Macrophage
Macrophage
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Neutrophil
Neutrophil
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Eosinophil
Eosinophil
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Basophil
Basophil
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Mast Cell
Mast Cell
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What is apoptosis?
What is apoptosis?
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What is phagocytosis?
What is phagocytosis?
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What is Chemotaxis?
What is Chemotaxis?
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In phagocytosis, what is adherence?
In phagocytosis, what is adherence?
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In phagocytosis, what is ingestion?
In phagocytosis, what is ingestion?
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In phagocytosis, what is digestion?
In phagocytosis, what is digestion?
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In phagocytosis, what is killing?
In phagocytosis, what is killing?
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What is Pus?
What is Pus?
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What are Natural Killer cells?
What are Natural Killer cells?
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What are Perforins?
What are Perforins?
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What are Interferons?
What are Interferons?
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What is the Complement system?
What is the Complement system?
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What are Iron-binding proteins?
What are Iron-binding proteins?
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What is Inflammation?
What is Inflammation?
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What is Vasodilation?
What is Vasodilation?
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Study Notes
Microbiology and Biochemistry - Body Defense (Non-Specific)
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The body has innate (non-specific) and adaptive (specific) defenses against infection.
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Innate defenses target all microorganisms, while adaptive defenses target specific pathogens.
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First line defense is a mechanical and chemical barrier.
- Mechanical protection: Skin (epidermis), mucous membranes, hairs, and mucus trap and filter microbes, dust, and pollutants. Tears, saliva, and urine wash microbes away.
- Chemical protection: Sebum, perspiration, lysozyme, gastric juice (low pH), and vaginal secretions inhibit microbial growth.
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Second line defense:
- Phagocytes: Large white blood cells that engulf and destroy microbes and debris. Types include neutrophils, macrophages, monocytes, basophils, eosinophils, and mast cells. -neutrophils: phagocytize bacteria, and short lived. After entering tissue, neutrophils will liv eonly in few hours. -eosinopils: secrete enzymes to kill parasitic worms. -basophils: contain granules of toxic chemicals that can digest foreign microorganisms. These are cells involved in allergic response. -basophils: contain granules of toxic chemicals that can digest foreign microorganisms. These are cells involved in an allergic response. -*mast cell: contain variety of inflammatory chemicals including histamine and serotonin. Cause vasodilatation of blood vessels near wound. -macrophage is a big eater come from matured monocytes, consist of 2 which are fixed macrophage and wondering macrophage.
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wondering macrophage: migrate to the tissues in search and destroying microbes and cellular debris -fixed macrophage: a permanent resident of the specific organ in the body. -process of macrophage attacking the body: macrophage will attack microbe in the body, then engulfs the microbe and displays some parts on its surface. After that, the immune response will initiated. Proteins are then secreted and body temperature wil rise. Monocytes will begin maturing into macrophage back. - Phagocytosis is a process of ingestion, destruction, and killing of microbes or foreign particles. The process involves: chemotaxis, adherence, ingestion, digestion, and killing of the microbe. Dead phagocytes and cellular debris form pus. -apoptosis: a process of a death of a cell.
- Natural Killer (NK) cells: Lymphocytes capable of killing a wide range of microbes and tumor cells. They release perforins that damage the target cell membrane, causing cytolysis. Found in lymph nodes, spleen, and bone marrow.
- Antimicrobial proteins: Proteins such as interferon, complement, and iron-binding proteins that enhance immune response, inhibit microbial growth, and attract immune cells.
- Inflammation: A defensive response to tissue damage, caused by microbes, physical agents, or chemical agents. Inflammation aims to dispose of microbes, toxins, and foreign material; prevent spreading; prepare the site for repair; and restore tissue homeostasis.
- Symptoms include redness, heat, swelling, pain, and loss of function (depending on injury site). Stages include vasodilation, increased permeability (edema), and phagocyte mobilization (chemotaxis, emigration/diapedesis)
- Symptoms of vasodilation: Increased blood flow (hyperemia), removal of toxins/dead cells, increased oxygen/nutrients delivery.
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Fever: An increase in body temperature caused by infection from bacteria or viruses. It increases body metabolic rate, speeds up immune defenses and tissue repair, and increases the effects of antimicrobial substances. High body temp can inhibit microbial growth and stimulate activity of phagocytes.
Summary of Second Line of Defense
- While powerful, second-line defense isn't perfect. Some pathogens will survive the attack.
- Second-line defense doesn't have memory, unlike adaptive immunity. This is why a third line of defense is necessary.
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Description
Explore the mechanisms of the body's innate (non-specific) and adaptive (specific) defenses against infections. Learn about the first and second lines of defense, including mechanical barriers like skin and chemical agents that inhibit microbial growth. Understand the role of phagocytes in the immune response.