Podcast
Questions and Answers
What is metastasis?
What is metastasis?
- The spread of tumour from a primary site to a distant secondary location (correct)
- The process of tumour cells differentiating into healthy cells
- The process of tumour cells adapting to their environment
- The process of tumour cells invading surrounding tissue
What percentage of tumour cells survive in circulation after 24 hours?
What percentage of tumour cells survive in circulation after 24 hours?
- 1%
- < 0.1% (correct)
- > 50%
- 10%
What is the first phase of the metastatic cascade?
What is the first phase of the metastatic cascade?
- Invasion of ECM (correct)
- Tissue homing and colonization
- Vascular dissemination
- Detachment of tumour cells
What is the minimum number of tumour cells required to form a metastasis?
What is the minimum number of tumour cells required to form a metastasis?
What is intravasation?
What is intravasation?
What is the main reason for mortality in cancer patients?
What is the main reason for mortality in cancer patients?
What is pagetoid infiltration named after?
What is pagetoid infiltration named after?
What is the term 'pagetoid' used to describe in dermatology?
What is the term 'pagetoid' used to describe in dermatology?
How many pathways are there for tumour cells to spread?
How many pathways are there for tumour cells to spread?
What is one way tumour cells can disseminate through?
What is one way tumour cells can disseminate through?
What is the pattern of cancer cell invasion seen in a few other epithelial malignancies?
What is the pattern of cancer cell invasion seen in a few other epithelial malignancies?
What is the single most important criterion for malignancy?
What is the single most important criterion for malignancy?
What serves as a clear line of demarcation for epithelial tumours?
What serves as a clear line of demarcation for epithelial tumours?
What is the combination of molecules that forms interstitial connective tissue?
What is the combination of molecules that forms interstitial connective tissue?
What is the first major step in tumour invasion of ECM?
What is the first major step in tumour invasion of ECM?
What type of enzymes are involved in the degradation of ECM?
What type of enzymes are involved in the degradation of ECM?
What is the reason why biopsies of testicular masses are never done?
What is the reason why biopsies of testicular masses are never done?
Which type of cavity is prone to direct seeding and transcoelomic spread?
Which type of cavity is prone to direct seeding and transcoelomic spread?
What is a clinical example of lymphatic spread in the breast?
What is a clinical example of lymphatic spread in the breast?
What is the term for the distended limb due to obstructed lymphatics?
What is the term for the distended limb due to obstructed lymphatics?
What is the characteristic of Krukenberg's tumour?
What is the characteristic of Krukenberg's tumour?
What is the primary site of haematogenous spread in renal cell carcinoma?
What is the primary site of haematogenous spread in renal cell carcinoma?
What is the most common pathway of dissemination for carcinomas?
What is the most common pathway of dissemination for carcinomas?
What is the purpose of sentinel lymph node mapping?
What is the purpose of sentinel lymph node mapping?
Which of the following is a rare site of metastasis?
Which of the following is a rare site of metastasis?
What happens to the lymph nodes when tumour cells reach them via afferent lymphatic channels?
What happens to the lymph nodes when tumour cells reach them via afferent lymphatic channels?
What is the term for the growth of tumour cells into small blood vessels at the site of primary neoplasm?
What is the term for the growth of tumour cells into small blood vessels at the site of primary neoplasm?
Which type of carcinoma penetrates portal and hepatic radicles and grows into main venous channels?
Which type of carcinoma penetrates portal and hepatic radicles and grows into main venous channels?
