Mesangial Cells: Structure and Function

Mesangial Cells: Structure and Function

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Questions and Answers

Mesangial cells are primarily located in which part of the glomerulus?

Within the stalk of the capillary tuft and the vascular pole

What is the primary function of the mesangial cells in the glomerulus?

To participate in maintenance of the basement membrane through phagocytosis and structural support

Which of the following components of the blood renal barrier prevents the passage of red blood cells?

The pores in the capillary endothelium

What is the composition of the slit diaphragms in the filtration slits?

<p>Nephrins, other proteins, glycoproteins, and proteoglycans</p> Signup and view all the answers

What is the function of the lamina rara interna in the glomerular basement membrane?

<p>To provide a surface for the glomerular endothelium to attach to</p> Signup and view all the answers

What is the ultimate function of the mesangial cell contractions in response to blood pressure changes?

<p>To maintain an optimal filtration rate</p> Signup and view all the answers

What is the primary function of the glomerular basement membrane in the filtration barrier?

<p>To restrict the passage of proteins larger than 70 kDa</p> Signup and view all the answers

In which region of the nephron are the cells smaller than in the PCT, with short microvilli and basolateral folds?

<p>DCT</p> Signup and view all the answers

What is the main function of Principal cells in the collecting ducts?

<p>To reabsorb Na+ and secrete K+, responding to aldosterone and ADH</p> Signup and view all the answers

What is the characteristic feature of the glomerular filter in diabetes mellitus and glomerulonephritis?

<p>It becomes more permeable to proteins, leading to proteinuria</p> Signup and view all the answers

Which type of cells in the collecting ducts are responsible for maintaining acid-base balance?

<p>Dark (intercalated) cells</p> Signup and view all the answers

What is the name of the duct that forms at the apex of each renal pyramid, where several medullary collecting ducts merge?

<p>Papillary duct (or duct of Bellini)</p> Signup and view all the answers

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