Podcast
Questions and Answers
What is the therapeutic classification of memantine?
What is the therapeutic classification of memantine?
- Antipsychotic
- Anti-Alzheimer's agents (correct)
- Antidepressant
- Anticonvulsant
What action does memantine perform on the NMDA receptor?
What action does memantine perform on the NMDA receptor?
Binds to CNS N-methyl-D-aspartate (NMDA) receptor sites, preventing binding of glutamate.
The initial dose of immediate-release memantine is ___ mg once daily.
The initial dose of immediate-release memantine is ___ mg once daily.
5
What is the route of administration for memantine in adults?
What is the route of administration for memantine in adults?
Which of the following conditions is an indication for memantine use?
Which of the following conditions is an indication for memantine use?
List two side effects of memantine.
List two side effects of memantine.
What should the patient do if a dose of memantine is missed?
What should the patient do if a dose of memantine is missed?
Match the nursing implications related to memantine administration:
Match the nursing implications related to memantine administration:
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Study Notes
Classification
- Therapeutic: anti-Alzheimer's agents
- Pharmacologic: N-methyl-D-aspartate (NMDA) antagonist
Action
- Binds to CNS NMDA receptor sites, preventing the binding of glutamate, an excitatory neurotransmitter
- Therapeutic effects include decreased symptoms of dementia and cognitive decline
- Does not slow progression or cure the disease; may enhance cognitive abilities
Dose
- Immediate-release: Start with 5 mg once daily; increase weekly to reach target dose of 20 mg/day (10 mg twice daily)
- Extended-release: Start with 7 mg once daily; increase weekly to reach target dose of 28 mg once daily
Route
- Administered orally (PO) in adults
Indications
- Used for moderate to severe dementia or neurocognitive disorder associated with Alzheimer's disease
Side Effects
- CNS: Dizziness, fatigue, headache, sedation
- CV: Hypertension
- Dermatological: Rash
- GI: Diarrhea, weight gain
- GU: Urinary frequency
- Hematological: Anemia
Nursing Implications
- Regularly assess cognitive function (memory, attention, reasoning, language, ability to perform simple tasks)
- Monitor for potential anemia through lab tests
Patient/Family Teaching
- Provide instructions on administration and titration of memantine
- Take missed doses promptly, but avoid taking before the next scheduled dose; do not double doses
- Consult healthcare provider (HCP) for missed doses extending beyond several days, possibly requiring a lower resuming dose
- Caution about the potential for dizziness
- Advise discussing all medications, including over-the-counter, vitamins, and herbal products with HCP before starting new medications
- Inform that cognitive improvement may take months, and the degenerative process is not reversible
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