Questions and Answers
What is the therapeutic classification of memantine?
What action does memantine perform on the NMDA receptor?
Binds to CNS N-methyl-D-aspartate (NMDA) receptor sites, preventing binding of glutamate.
The initial dose of immediate-release memantine is ___ mg once daily.
5
What is the route of administration for memantine in adults?
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Which of the following conditions is an indication for memantine use?
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List two side effects of memantine.
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What should the patient do if a dose of memantine is missed?
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Match the nursing implications related to memantine administration:
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Study Notes
Classification
- Therapeutic: anti-Alzheimer's agents
- Pharmacologic: N-methyl-D-aspartate (NMDA) antagonist
Action
- Binds to CNS NMDA receptor sites, preventing the binding of glutamate, an excitatory neurotransmitter
- Therapeutic effects include decreased symptoms of dementia and cognitive decline
- Does not slow progression or cure the disease; may enhance cognitive abilities
Dose
- Immediate-release: Start with 5 mg once daily; increase weekly to reach target dose of 20 mg/day (10 mg twice daily)
- Extended-release: Start with 7 mg once daily; increase weekly to reach target dose of 28 mg once daily
Route
- Administered orally (PO) in adults
Indications
- Used for moderate to severe dementia or neurocognitive disorder associated with Alzheimer's disease
Side Effects
- CNS: Dizziness, fatigue, headache, sedation
- CV: Hypertension
- Dermatological: Rash
- GI: Diarrhea, weight gain
- GU: Urinary frequency
- Hematological: Anemia
Nursing Implications
- Regularly assess cognitive function (memory, attention, reasoning, language, ability to perform simple tasks)
- Monitor for potential anemia through lab tests
Patient/Family Teaching
- Provide instructions on administration and titration of memantine
- Take missed doses promptly, but avoid taking before the next scheduled dose; do not double doses
- Consult healthcare provider (HCP) for missed doses extending beyond several days, possibly requiring a lower resuming dose
- Caution about the potential for dizziness
- Advise discussing all medications, including over-the-counter, vitamins, and herbal products with HCP before starting new medications
- Inform that cognitive improvement may take months, and the degenerative process is not reversible
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Description
Test your knowledge on Memantine (Namenda) with these informative flashcards. Each card highlights key classifications, actions, and therapeutic effects of this anti-Alzheimer's medication. Perfect for students and healthcare professionals alike.
