Questions and Answers
What class of drug is Memantine?
What is the mechanism of action (MOA) of Memantine?
Binds NMDA receptors. May slow Ca++ influx and nerve damage.
Which of the following are indications for Memantine? (Select all that apply)
Dofetilide is contraindicated with Memantine.
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What is a potential adverse reaction of Memantine?
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What precautions should be taken when administering Memantine?
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What drug interactions should be noted with Memantine?
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The usual Memantine dosage includes ______ mg and ______ mg.
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Study Notes
Memantine Overview
- Memantine is classified as an NMDA antagonist, affecting neurotransmission in the brain.
Mechanism of Action (MOA)
- It binds to NMDA receptors, potentially slowing calcium influx, which may help prevent nerve damage.
Indications
- Primarily prescribed for Alzheimer's disease and other types of dementia.
Contraindications
- Concurrent use of dofetilide with Memantine is prohibited due to increased risks.
Adverse Reactions
- One serious adverse reaction associated with Memantine is Stevens-Johnson syndrome, a severe skin reaction.
Precautions
- Caution is recommended in patients who may undergo urinary alkalinization, as it can alter drug metabolism.
Drug Interactions
- The combination of dofetilide and Memantine has significant contraindications, notably an increased risk of QT prolongation.
Dosage and Administration
- Typical dosages of Memantine include starting doses of 5 mg, with potential increases to 10 mg based on tolerance and clinical response.
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Description
This quiz covers the essential aspects of Memantine, including its classification, mechanism of action, and indications. Learn about its use in treating Alzheimer's disease and the precautions needed for safe administration. Understand the risks of contraindications and adverse reactions associated with Memantine.
