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Questions and Answers
What is the brand name of the medication Memantine?
What is the brand name of the medication Memantine?
Namenda
What is the generic name of the medication Namenda?
What is the generic name of the medication Namenda?
Memantine
What are the indications for the use of Memantine?
What are the indications for the use of Memantine?
For the treatment of moderate to severe dementia of the Alzheimer's type
What is the recommended starting dose of Memantine tablets?
What is the recommended starting dose of Memantine tablets?
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What are the available strengths of Memantine tablets?
What are the available strengths of Memantine tablets?
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What is the medication class of Memantine?
What is the medication class of Memantine?
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What is the mechanism of action of Memantine?
What is the mechanism of action of Memantine?
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What type of drugs may reduce the renal elimination of Memantine?
What type of drugs may reduce the renal elimination of Memantine?
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What are some common side effects of Memantine?
What are some common side effects of Memantine?
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What is a contraindication for the use of Memantine?
What is a contraindication for the use of Memantine?
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How should Memantine be stored?
How should Memantine be stored?
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Study Notes
Memantine Overview
- Memantine is a medication used to treat moderate to severe dementia of the Alzheimer's type.
- It is available under the brand name Namenda and also in its generic form.
Indications and Dosage
- The recommended starting dose for tablets and solution is 5 mg once daily, increasing to 10 mg twice a day with a target dose of 20 mg per day.
- Capsules are started at 7 mg once daily, titrated up to 28 mg once daily, with a minimum of 7 days between dose increases.
Forms and Strengths
- Memantine is available in various forms: tablets (5 mg and 10 mg), capsules (7 mg, 14 mg, 21 mg, and 28 mg), and oral solution (2 mg/mL).
Mechanism of Action
- Memantine acts as a low to moderate affinity uncompetitive NMDA receptor antagonist, reducing persistent activation of NMDA receptor-operated cation channels.
Drug Interactions
- Drugs that alkalinize the urine can reduce the renal elimination of memantine, but this is not a contraindication.
Side Effects
- Common side effects include dizziness, headache, confusion, hypertension, pain, fatigue, vomiting, coughing, hallucination, and somnolence, with none exceeding 10% incidence.
Contraindications
- Hypersensitivity to any component of the drug, renal impairment, and pregnancy are contraindications.
- Daily doses above 5 mg should be given twice a day, with dose increases not sooner than once a week.
Patient Counseling
- Memantine can be taken with or without food.
- It should be stored in a cool, dry place away from sunlight and children.
- Patients should contact a physician if side effects are severe or persistent.
- If a dose is missed, it should be skipped and the normal dosing schedule resumed; doses should not be doubled.
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Description
This quiz covers the medication Memantine, used to treat moderate to severe dementia of the Alzheimer's type. It includes indications, dosage, forms, strengths, mechanism of action, and drug interactions.
