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Meloxicam
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Meloxicam

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@BoomingSeal

Questions and Answers

Which enzyme is responsible for the synthesis of prostaglandins?

  • COX-2
  • COX-4
  • COX-3
  • COX-1 (correct)

    • Which type of NSAID is known for its selective inhibition of COX-2?

  • Preferential COX-2 inhibitors (correct)
  • Salicylates
  • Propionic acid derivatives
  • Anthranilic acid derivatives

    • Which NSAID is classified as a pyrazolone derivative?

  • Ketorolac (correct)
  • Phenylbutazone
  • Ibuprofen
  • Naproxen

    • Which drug is commonly used as an analgesic and antipyretic, but has poor anti-inflammatory action?

    <p>Paracetamol</p> Signup and view all the answers

    Which drug is contraindicated in pregnant women and peptic ulcer patients?

    <p>Aspirin</p> Signup and view all the answers

    Which drug is an alternative to aspirin and is better tolerated orally?

    <p>Ibuprofen</p> Signup and view all the answers

    Which drug is highly bound to plasma proteins and should never be used with anticoagulants?

    <p>Naproxen</p> Signup and view all the answers

    Which drug is a relatively selective COX2 congener of diclofenac sodium?

    <p>Aceclofenac</p> Signup and view all the answers

    Which of the following is a common side effect of the NSAID described in the text?

    <p>Rashes</p> Signup and view all the answers

    Which NSAID is recommended for short and long term anti-inflammatory conditions?

    <p>Piroxicam</p> Signup and view all the answers

    Which NSAID has been observed to cause reversible azotaemia?

    <p>Ketorol</p> Signup and view all the answers

    Which NSAID is a weak inhibitor of prostaglandin synthesis?

    <p>Propiphenazone</p> Signup and view all the answers

    Which of the following is the main mechanism of action of NSAIDs?

    <p>Inhibition of prostaglandin generation</p> Signup and view all the answers

    Which of the following is NOT a property of NSAIDs?

    <p>Antibiotic</p> Signup and view all the answers

    Which of the following endogenous agents have been associated with gingivitis, periodontitis, and alveolar bone resorption?

    <p>Prostaglandins, prostacyclins, and TXA2</p> Signup and view all the answers

    Which of the following drugs was introduced as an alternative to salicylic acid?

    <p>Aspirin</p> Signup and view all the answers

    Which drug has a COX2:COX1 selectivity ratio of 10?

    <p>Meloxicam</p> Signup and view all the answers

    Which drug is a newer congener of piroxicam?

    <p>Meloxicam</p> Signup and view all the answers

    Which drug is labeled as a preferred COX2 inhibitor?

    <p>Meloxicam</p> Signup and view all the answers

    Which drug is effective in treating rheumatoid arthritis, osteoarthritis, and soft tissue injury?

    <p>Meloxicam</p> Signup and view all the answers

    Which of the following is a true statement about the analgesic action of aspirin?

    <p>Aspirin relieves tissue injury related inflammation and integumental pain effectively.</p> Signup and view all the answers

    Which of the following is a true statement about the anti-inflammatory action of aspirin?

    <p>Aspirin inhibits the synthesis of clotting factors in the liver.</p> Signup and view all the answers

    Which of the following is a true statement about the metabolism and elimination of aspirin?

    <p>Aspirin is primarily eliminated through renal excretion.</p> Signup and view all the answers

    Which of the following is a true statement about the side effects of aspirin?

    <p>Epigastric distress and nausea are the most common side effects of aspirin.</p> Signup and view all the answers

    Which of the following NSAIDs significantly slowed the rate of alveolar bone loss in periodontitis when administered daily for up to 3 years?

    <p>Naproxen</p> Signup and view all the answers

    What are the significant side effects associated with long-term NSAID use for periodontal benefits?

    <p>Gastrointestinal problems and hemorrhage</p> Signup and view all the answers

    What happens to the periodontal benefits of long-term NSAID use when patients stop taking the drugs?

    <p>The benefits are lost</p> Signup and view all the answers

    Which type of NSAID causes gastrointestinal ulceration and impaired hemostasis?

    <p>Nonselective NSAIDs</p> Signup and view all the answers

    How long is the necessary duration of extended NSAID use for periodontal benefits to become apparent?

    <p>6 months</p> Signup and view all the answers

    What is the term used to describe the return to or acceleration of the rate of bone loss seen before NSAID therapy when patients stop taking the drugs?

    <p>Rebound effect</p> Signup and view all the answers

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