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Questions and Answers
Which medication is typically the initial analgesic therapy for most patients with OA?
Why must COX-2 enzyme blockers be used with caution in OA patients?
Which medication may be considered for some patients with OA who are refractory to other treatments, despite being typically prescribed for treating RA?
Which topical analgesic agent has been FDA approved for the use of osteoarthritic joint pain in the hands and knees?
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What is the main consideration for selecting medication for OA management?
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In severe cases of OA, which type of medication may be considered?
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Which medication is used in conjunction with nonpharmacologic strategies for OA management?
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Which medication has little to no decrease in GI upset and is associated with a risk of cardiovascular disease?
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Which medication is typically prescribed for treating gout but may also be considered for some patients with OA?
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Which medication is an example of a nonopioid that may be considered for OA management?
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Which medication is an example of an opioid that may be considered in severe cases of OA?
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Which medication is used for treating RA but may also be considered for some patients with OA?
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Which enzyme does meloxicam inhibit?
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What is the excretion route for meloxicam?
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In which sites is meloxicam more selective for COX-2 inhibition?
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For which type of renal impairment are dosage adjustments not required for meloxicam?
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What is a contraindication for meloxicam?
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Which medications can interact with meloxicam, increasing its effects?
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What is the recommended administration method to reduce gastric irritation when taking meloxicam?
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What should be done before using the oral suspension of meloxicam?
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What are the nursing implications for meloxicam?
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What are the patient teaching guidelines for meloxicam?
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Which drug is mentioned as being in the same class as meloxicam?
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Study Notes
Meloxicam: Drug Therapy for Osteoarthritis
- Meloxicam is a COX-1 and COX-2 inhibitor used for the treatment of osteoarthritis and rheumatoid arthritis
- It is metabolized by the liver, excreted in feces and urine, with an onset of action in 1 hour and peak serum concentrations in 5 to 6 hours
- Meloxicam is more selective for COX-2 inhibition in the brain, kidney, ovary, uterus, cartilage, bone, and sites of inflammation
- Dosage adjustments of meloxicam are not required for mild to moderate renal impairment, but it is not recommended for patients with severe renal impairment
- The use of meloxicam in patients with hepatic impairment has not been adequately studied, and the dosage adjustment is not necessary for mild to moderate hepatic impairment
- Adverse effects of meloxicam include respiratory, hematologic, gastrointestinal, cardiovascular events, and GI bleeding
- Contraindications for meloxicam include known aspirin allergy and postoperative administration in patients who have undergone coronary artery bypass surgery
- Medications such as alcohol, garlic, ginseng, and ginger can interact with meloxicam, increasing its effects
- Administration of meloxicam with food or fluids reduces gastric irritation, and shaking the oral suspension before use is necessary
- Nursing implications include assessing for therapeutic effects such as pain relief, reduced fever, and inflammation, as well as monitoring for adverse effects and hypersensitivity reactions
- Patient teaching guidelines for meloxicam include taking the drug with food, following the prescribed dose, and reporting any adverse effects to the healthcare provider
- Diclofenac is another drug in the same class as meloxicam, which also inhibits COX-1 and COX-2 to produce an anti-inflammatory response
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Description
Test your knowledge of meloxicam, a drug therapy for osteoarthritis, with this quiz. Explore its mechanism of action, pharmacokinetics, contraindications, adverse effects, interactions, nursing implications, and patient teaching guidelines.
