Meloxicam
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Questions and Answers

Which of the following is a common side effect of aspirin at analgesic doses?

  • Increased blood sugar (correct)
  • Decreased blood sugar
  • Increased blood pressure
  • Decreased blood pressure

What is the main mechanism of action of aspirin as an analgesic?

  • Activation of opioid receptors
  • Inhibition of COX
  • Reduction of prostaglandin levels (correct)
  • Blockage of nerve impulses

Which of the following is a potential side effect of long-term aspirin use?

  • Increased risk of infection
  • Decreased risk of infection
  • Increased risk of bleeding (correct)
  • Decreased risk of bleeding

Which of the following is a characteristic of Reye's syndrome?

<p>Occurs in infants and children (D)</p> Signup and view all the answers

Which enzyme is inhibited by NSAIDs to relieve pain due to inflammation?

<p>COX-2 (D)</p> Signup and view all the answers

Which of the following is a non-selective COX inhibitor?

<p>Ibuprofen (D)</p> Signup and view all the answers

Which type of NSAID is most frequently used for mild-to-moderate pain?

<p>Propionic acid derivatives (C)</p> Signup and view all the answers

Which of the following is a shared toxicity due to prostaglandin synthesis inhibition by NSAIDs?

<p>Gastric mucosal damage (D)</p> Signup and view all the answers

Which drug is an alternative to aspirin and is better tolerated orally with low incidences of adverse reactions?

<p>Ibuprofen (C)</p> Signup and view all the answers

Which drug is contraindicated in pregnant women and peptic ulcer patients?

<p>Aspirin (C)</p> Signup and view all the answers

Which drug is highly bound to plasma proteins and should never be used with anticoagulants?

<p>Aspirin (A)</p> Signup and view all the answers

Which drug is commonly used in dentistry to suppress swelling and inflammation after tooth extraction?

<p>Ibuprofen (A)</p> Signup and view all the answers

Which of the following is a common side effect of using NSAIDs?

<p>Gastric ulceration (D)</p> Signup and view all the answers

What is the mechanism of action of NSAIDs?

<p>Reversible inhibition of COX (D)</p> Signup and view all the answers

Which NSAID can be used for parenteral administration?

<p>Ketorolac (B)</p> Signup and view all the answers

Which NSAID is a weak inhibitor of prostaglandin synthesis and exerts anti-inflammatory action through other mechanisms?

<p>Propiphenazone (A)</p> Signup and view all the answers

Which of the following is a potential side effect of long-term NSAID use for periodontal benefits?

<p>Gastrointestinal problems (A)</p> Signup and view all the answers

Which type of NSAID inhibits osteoclastic activity in periodontitis?

<p>Nonselective NSAIDs (B)</p> Signup and view all the answers

What happens to the periodontal benefits of long-term NSAID use when patients stop taking the drugs?

<p>They are lost (B)</p> Signup and view all the answers

Which of the following drugs is a newer congener of piroxicam and has a COX2:COX1 selectivity ratio of 10?

<p>Meloxicam (D)</p> Signup and view all the answers

Which drug should be avoided in the presence of severe hepatic/renal disease and in those receiving rifampin, warfarin, and methotrexate?

<p>Rofecoxib (D)</p> Signup and view all the answers

Which drug is a central analgesic and antipyretic, but a poor inhibitor of PG synthesis in peripheral tissues?

<p>Paracetamol (B)</p> Signup and view all the answers

Which drug is a good and promptly acting antipyretic, and does not affect platelet function or clotting factors?

<p>Paracetamol (D)</p> Signup and view all the answers

Which endogenous agents are involved in the complex mechanism of action of NSAIDs in relation to periodontitis?

<p>Prostaglandins, bradykinin, histamine, chemotactic factors &amp; superoxide free radicals (C)</p> Signup and view all the answers

Which properties do NSAIDs possess?

<p>Anti-inflammatory, analgesic, and antipyretic (D)</p> Signup and view all the answers

What was the main mechanism of action of NSAIDs discovered by John Vane and co-workers in 1971?

<p>Blocking prostaglandin generation (D)</p> Signup and view all the answers

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