29 Questions
What increases as the cell matures in megakaryopoiesis?
Cell size
Which of the following is NOT a recognizable stage in megakaryopoiesis?
Progenitor cell
Which zone of the platelet ultrastructure is responsible for maintaining the shape of the platelet?
Peripheral Zone
What is the primary function of platelets in the body?
Hemostasis
Which hormones and cytokines are involved in megakaryopoiesis?
Erythropoietin and Thrombopoietin
What can be observed and differentiated under the microscope in a bone marrow specimen during megakaryopoiesis?
'Recognizable Stages'
What is the main difference between BFU-Meg and CFU-Meg?
BFU-Meg undergoes mitosis, but CFU-Meg does not
What occurs at the LD-CFU-Meg stage in megakaryopoiesis?
It replicates DNA but no longer divides
Which blood component is considered most significant for hemostasis?
Platelets
What is unique about endomitosis in megakaryocytes?
Nucleus divides up to 32 times without cell division
What is the primary goal of hemostasis in the body?
To keep blood liquid and stop bleeding
In megakaryopoiesis, what is the maturation series specifically committed to producing?
Platelets
What is the main function of synthetic thrombopoietin?
Elevate platelet count
Which cytokine acts in synergy with TPO?
IL-11
What is the role of phospholipids in the platelet membrane?
Form the basic structure of platelets
How do inhibitors like PF4 and B-TG affect platelets?
Ensure only ample amount of platelets present
What is the consequence of having too many platelets in the body?
Increases risk of forming unwanted clots
At which stage of Megakaryopoiesis is the nucleus multilobed?
MK-III
Which phospholipid ensures that only an ample amount of platelets should be present within the body?
Phosphatidyl choline
In which stage of Megakaryopoiesis do cytoplasmic bluish-stained granules become visible?
BPromegakaryocyte (MK II)
Which stage of Megakaryopoiesis shows evidence of endomitosis?
BPromegakaryocyte (MK II)
Which Megakaryopoiesis stage has a 1:2 N:C ratio?
MK-II
Which Megakaryocyte stage has a diameter of 30-50um?
MK-III
What is the purpose of sequestering platelets in the spleen?
To release platelets quickly in cases of bleeding
After platelets are released, what do megakaryocytes transform into?
Naked megakaryocytes
What is thrombopoietin's role in platelet regulation?
Stimulate platelet production
Why is the plasma concentration of Thrombopoietin inversely proportional to platelet and megakaryocyte mass?
To regulate the release of platelet substances
Which zone of a platelet serves as the regulator for collecting substances needed for clot formation?
Peripheral Zone
What happens to the 'naked megakaryocytes' after they are phagocytized by macrophages?
They undergo apoptosis
Test your knowledge on the stages of Megakaryopoiesis, including MK-I and MK-II. Identify the characteristics and features of each stage, such as nucleus shape, granules, and mitosis type.
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