10 Questions
What is endomitosis in the context of thrombocytopoiesis?
Replication of chromosomes in the absence of nuclear division
What is the significance of the N:C ratio in thrombocytopoiesis?
N:C ratio stands for nucleus-cytoplasm ratio, which indicates the stage of megakaryocyte differentiation.
What are a-granules and their importance in platelets?
Alpha granules; important for adhesion in platelets (50-80 per platelet)
What role do d-granules (dense granules) play in thrombocytopoiesis?
Dense granules are important for granulation in platelets.
What is the main feature of the MK-I stage or megakaryoblast?
The least differentiated megakaryocyte precursor.
Describe the DMS (Demarcation System) in thrombocytopoiesis.
A series of membrane-lined channels that invade from the plasma membrane and subdivide the entire cytoplasm.
What is the unique morphology observed in bone marrow aspirate films during thrombocytopoiesis?
Wright-stained morphology.
What are the functions of procoagulant-laden a-granules in thrombocytopoiesis?
Development of cytoplasmic ultrastructure in megakaryoblasts.
What is the disease associated with a lack of a-granules in platelets?
Gray platelet syndrome.
How do the plasma membrane blebs and blunt projections in megakaryoblasts resemble platelets?
They form from the margin and resemble platelets.
Test your knowledge on the features of terminal megakaryocyte differentiation and platelet production. Compare the characteristics of different stages of megakaryocytes such as MK I, MK II, and MK III. Identify key differences in precursor percentage, diameter, nucleus structure, chromatin, cytoplasmic components, and more.
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