Megakaryocytopoiesis and Platelet Structure Features Quiz
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Questions and Answers

What is endomitosis in the context of thrombocytopoiesis?

Replication of chromosomes in the absence of nuclear division

What is the significance of the N:C ratio in thrombocytopoiesis?

N:C ratio stands for nucleus-cytoplasm ratio, which indicates the stage of megakaryocyte differentiation.

What are a-granules and their importance in platelets?

Alpha granules; important for adhesion in platelets (50-80 per platelet)

What role do d-granules (dense granules) play in thrombocytopoiesis?

<p>Dense granules are important for granulation in platelets.</p> Signup and view all the answers

What is the main feature of the MK-I stage or megakaryoblast?

<p>The least differentiated megakaryocyte precursor.</p> Signup and view all the answers

Describe the DMS (Demarcation System) in thrombocytopoiesis.

<p>A series of membrane-lined channels that invade from the plasma membrane and subdivide the entire cytoplasm.</p> Signup and view all the answers

What is the unique morphology observed in bone marrow aspirate films during thrombocytopoiesis?

<p>Wright-stained morphology.</p> Signup and view all the answers

What are the functions of procoagulant-laden a-granules in thrombocytopoiesis?

<p>Development of cytoplasmic ultrastructure in megakaryoblasts.</p> Signup and view all the answers

What is the disease associated with a lack of a-granules in platelets?

<p>Gray platelet syndrome.</p> Signup and view all the answers

How do the plasma membrane blebs and blunt projections in megakaryoblasts resemble platelets?

<p>They form from the margin and resemble platelets.</p> Signup and view all the answers

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