Medical Physiology: Cardiac Muscle and Heart Function
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Questions and Answers

What is the pericardium?

A double-walled sac that encloses the heart and isolates it from other organs.

Which of the following is a cause of pericarditis? (Select all that apply)

  • Trauma to the chest (correct)
  • Heart attack (correct)
  • Lung disease
  • Infection (correct)
  • The heart operates on its own.

    True

    What are intercalated discs?

    <p>Structures that join adjacent cardiac muscle cells end to end.</p> Signup and view all the answers

    The resting membrane potential of cardiac muscle is between _____ millivolts.

    <p>-85 to -95</p> Signup and view all the answers

    What happens during phase 0 of the ventricular muscle action potential?

    <p>Fast Na+ channels open.</p> Signup and view all the answers

    The fibrous insulator exists between which parts of the heart?

    <p>Atria and ventricles</p> Signup and view all the answers

    What is the purpose of the pericardial fluid?

    <p>To reduce friction between the heart and surrounding structures.</p> Signup and view all the answers

    Study Notes

    Heart Location and Associated Structures

    • The heart is located in the thoracic cavity, enclosed by various structures.
    • The pericardium is a double-walled sac surrounding the heart, preventing friction during beats and allowing expansion while resisting excessive stretching.
    • It is anchored inferiorly to the diaphragm and anteriorly to the sternum.

    The Pericardium

    • The pericardium has two main layers:
      • Parietal pericardium: The outer layer with a fibrous layer providing strength and a serous layer for lubrication.
      • Visceral pericardium (epicardium): A serous lining covering the heart directly.
    • The pericardial cavity contains 5 to 30 mL of pericardial fluid, aiding in smooth heart movement.

    Pericarditis

    • Pericarditis refers to the inflammation of the pericardium, often resulting from infections, heart attacks, trauma, or radiation.
    • Symptoms include chest pain and potential difficulty in heart function.
    • Common treatments involve NSAIDs, antibiotics, or pericardiocentesis to relieve pressure.

    Cardiac Muscle Structure

    • Cardiac muscle is composed of smaller cells (cardiac fibers) with a single nucleus and interconnected via intercalated discs.
    • Intercalated discs facilitate the mechanical and electrical connection between cardiac cells, featuring:
      • Desmosomes: Mechanically link neighboring cells.
      • Gap Junctions: Allow electrical impulses to propagate rapidly.

    Function of Cardiac Muscle

    • Cardiac muscle operates autonomously; contractions are triggered by electrical impulses generated within the heart.
    • Each contraction is an "all or none" event, due to the syncytial nature of the muscle, meaning all connected cells contract fully.
    • The atria and ventricles contract as separate functional syncytia due to a fibrous insulator that separates them.

    Action Potentials in Cardiac Muscle

    • Resting membrane potential of cardiac muscle cells ranges from -85 to -95 mV.
    • Action potential peaks at approximately +105 mV, distinguished by a prolonged plateau lasting around 0.2-0.3 seconds—significantly longer than in skeletal muscle.
    • Cardiac muscle action potential phases include:
      • Phase 0: Fast sodium channels open, leading to depolarization.
      • Phase 1: Potassium channels open, initiating repolarization.

    Key Physiological Concepts

    • The heart's conduction system is crucial for synchronizing contractions.
    • Cardiac muscle cells are rich in mitochondria and myoglobin, enabling high energy demands during pumping cycles.
    • The coordinated contraction and relaxation of the heart are essential for effective circulation throughout the body.

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    Description

    This quiz focuses on the structure and function of cardiac muscle and how the heart operates as a pump. It is designed for students in the Masters of Medical Sciences program at LECOM-Bradenton. Assess your understanding of cardiology concepts, including the pericardium and associated structures.

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