MED437 Histology: Thyroid and Parathyroid Glands
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Questions and Answers

What is the primary structural and functional unit of the thyroid gland?

  • Follicular cell
  • Parafollicular cell
  • Thyroid follicle (correct)
  • Colloid
  • What type of connective tissue forms the capsule and septa of the thyroid gland?

  • Areolar connective tissue
  • Dense irregular collagenous connective tissue (correct)
  • Elastic connective tissue
  • Adipose tissue
  • Which type of cell in the thyroid gland is responsible for the synthesis of thyroglobulin?

  • Capillary endothelial cells
  • Reticular cells
  • Follicular cells (correct)
  • Parafollicular cells
  • Where are parafollicular cells typically located within a thyroid follicle?

    <p>Between the follicular cells, in the periphery of the follicle (D)</p> Signup and view all the answers

    What is the function of the colloid found within the thyroid follicles?

    <p>To store precursor molecules for thyroid hormone synthesis (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of parafollicular cells?

    <p>They are smaller than follicular cells (B)</p> Signup and view all the answers

    What is the primary function of the reticular fibers surrounding thyroid follicles?

    <p>To create a network for nutrient and waste exchange between follicles and capillaries (D)</p> Signup and view all the answers

    Which of the following statements accurately describes the structure of the thyroid gland?

    <p>It consists of numerous lobules, each containing multiple thyroid follicles. (C), It is a highly vascularized gland, with a rich supply of blood vessels and capillaries. (D)</p> Signup and view all the answers

    Which of the following is true regarding the structure whose apices do NOT reach the follicle lumen?

    <p>It is composed of parafollicular cells. (A)</p> Signup and view all the answers

    What is the primary function of the chief cells in the parathyroid gland?

    <p>Secrete parathyroid hormone. (B)</p> Signup and view all the answers

    Which of the following cell types is characterized by an abundance of mitochondria?

    <p>Oxyphil cells (B)</p> Signup and view all the answers

    Which of the following is a characteristic of the thyroid gland stroma?

    <p>It is composed of thin connective tissue with a rich capillary plexus. (B)</p> Signup and view all the answers

    Which of the following cell types can be found singly or in clusters within the thyroid gland?

    <p>Parafollicular cells (B)</p> Signup and view all the answers

    Which of these cell types is responsible for producing thyroid hormones?

    <p>Follicular cells (C)</p> Signup and view all the answers

    Which of the following histological structures is NOT found in the parathyroid gland?

    <p>Colloid (A)</p> Signup and view all the answers

    Which of the following statements is TRUE about the structure of the thyroid gland?

    <p>The thyroid gland is comprised of numerous follicles, each containing colloid. (B)</p> Signup and view all the answers

    What is the function of the numerous apical short microvilli present in thyroid follicular epithelial cells?

    <p>Increase surface area for secretion of thyroglobulin (A)</p> Signup and view all the answers

    How are the secretory vesicles distributed in thyroid and parathyroid glands?

    <p>Apical in thyroid glands and basal in parathyroid glands (A)</p> Signup and view all the answers

    What is the role of peroxidase enzyme in thyroid hormone synthesis?

    <p>Converting iodide ions into iodine (C)</p> Signup and view all the answers

    Which of the following structures is responsible for the organization of the parathyroid gland parenchyma?

    <p>All of the above (D)</p> Signup and view all the answers

    Which type of cells in the parathyroid gland is responsible for the secretion of parathyroid hormone?

    <p>Chief cells (C)</p> Signup and view all the answers

    What is the difference in morphology between chief cells and oxyphil cells?

    <p>Oxyphil cells are larger and less numerous than chief cells (A)</p> Signup and view all the answers

    What is the relationship between calcitonin and parathyroid hormone in regulating calcium levels?

    <p>Calcitonin decreases blood calcium levels, while parathyroid hormone increases it (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the thyroid gland?

    <p>Presence of chief cells and oxyphil cells (A)</p> Signup and view all the answers

    Flashcards

    Thyroid Gland Structure

    The thyroid gland consists of parenchyma (functional units) and stroma (support tissue).

    Thyroid Follicles

    Thyroid follicles are the structural and functional units of the thyroid, lined with epithelium.

    Follicular Cells

    Follicular cells are simple cuboidal epithelial cells that line thyroid follicles and produce thyroglobulin.

    Parafollicular Cells

    Parafollicular cells (C-cells) are pale-stained cells found between thyroid follicles, producing calcitonin.

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    Colloid

    Colloid is a gel-like substance within the thyroid follicles, filled with thyroglobulin.

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    Thyroid Epithelium

    The epithelium of the thyroid gland is simple cuboidal, allowing for hormone synthesis and secretion.

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    Basal Lamina

    Each thyroid follicle is surrounded by a thin basal lamina providing structural support.

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    Parathyroid Gland Function

    The parathyroid glands regulate calcium levels in the blood through parathyroid hormone (PTH).

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    Thyroid Gland Function

    Synthesize thyroid hormones (T4 & T3) and secrete calcitonin.

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    Lysosomes

    Organelles that contain enzymes, converting reduced iodine to iodine.

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    Calcitonin

    Hormone secreted by the thyroid that lowers blood calcium levels.

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    Parathyroid Glands

    Four glands located posterior to the thyroid gland that regulate calcium levels.

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    Chief Cells

    Epithelial cells in the parathyroid that secrete parathyroid hormone.

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    Oxyphil Cells

    Larger, less numerous cells in parathyroid glands of unknown function.

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    Thyroid Follicle Epithelium

    The epithelium of thyroid follicles is primarily simple cuboidal.

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    Secretion Sites

    Vesicles located apically in thyroid gland; basal in parathyroid.

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    Characteristic of oxyphil cells

    Oxyphil cells are known for having abundant mitochondria and being slightly eosinophilic.

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    Characteristic of chief cells

    Chief cells are basophilic and rich in rough endoplasmic reticulum (rER).

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    Thin CT with capillary plexus

    The stroma of the thyroid gland characterized by its thin connective tissue structure filled with blood vessels.

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    Cells found singly or in clusters

    Clear cells or principal cells can both appear as isolated units or in groups.

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    Study Notes

    Thyroid and Parathyroid Glands: Overview

    • The presentation covers the thyroid and parathyroid glands, highlighting important information for MED437 Histology.
    • Important details are marked in red, while information relevant to male/female slides is in black. Additional notes are shown in gray.

    Objectives

    • Describe the histological structure of the thyroid gland.
    • Identify and correlate different endocrine cells in the thyroid gland and their functions.
    • Describe the microscopic structure of the parathyroid gland.
    • Describe the functional structure of the parathyroid cells.

    Thyroid Gland: Parenchyma and Stroma

    • Parenchyma: The structural and functional units of the thyroid gland, consisting of thyroid follicles.
    • Follicles: Simple cuboidal epithelium (a) follicular cells, (b) parafollicular cells, and a central colloid-filled lumen.
    • Colloid: A gel-like material within the follicles.
    • Basal Lamina: A thin layer surrounding each follicle.
    • Stroma: The connective tissue surrounding the follicles.
      • Capsule: A dense irregular collagenous connective tissue layer.
      • Septa: Interlobular septa, extending into the gland.
      • Reticular Fibers: Thin connective tissue with rich capillary plexuses, providing blood supply.

    Thyroid Gland: Cells

    • Follicular Cells (Principal Cells):
      • Simple cuboidal cells
      • Prominent nuclei with prominent cytoplasm
      • Facilitate thyroglobulin synthesis and thyroid hormone synthesis.
    • Parafollicular Cells (C-cells):
      • Located between the follicular cells
      • Pale-staining (clear cells)
      • Larger than follicular cells
      • Secrete calcitonin (a hormone involved in calcium regulation).

    Parathyroid Glands: Parenchyma and Stroma

    • Parenchyma: Formed by cords or clusters of epithelial cells (chief cells and oxyphil cells), with blood capillaries in between. Reticular fibers surround these cells.
    • Chief Cells: Eosinophilic, rich in rER, responsible for parathyroid hormone secretion.
    • Oxyphil Cells: Larger than chief cells, have abundant mitochondria.
    • Stroma: Gland capsule, thin septa, reticular C.T., and often includes adipose tissue.

    Additional Information

    • The total number of parathyroid glands is four.
    • They are located on the posterior aspect of the thyroid gland.
    • The presentation includes various questions about the histology of thyroid and parathyroid glands. (e.g. What is the epithelium of thyroid follicles, what are the cells responsible for making T4 and T3, what histological structures are not in parathyroid glands etc)

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    Description

    This quiz focuses on the histological structure and functions of the thyroid and parathyroid glands as covered in MED437. It covers the parenchyma, stroma, and different endocrine cells associated with these glands. Understand key concepts through detailed histological descriptions and structural characteristics.

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