Mechanisms of Antimicrobial Drugs

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Questions and Answers

What approach involves the constructive use of formulation ingredients to enhance the activity of the original preservative agent?

  • Bioavailability optimization
  • Antimicrobial synergy
  • Hurdle technology (correct)
  • Biodegradable technology

In optimizing biocide formulations, what is particularly important in situations of pH dependency or poor water solubility?

  • Ensuring maximum availability of the active moiety (correct)
  • Enhancing aroma
  • Improving color intensity
  • Maximizing shelf life

What is a key consideration in modeling the activity of biocidal agents apart from temperature and pH?

  • Presence of extraneous matter (correct)
  • Humidity levels
  • Type of packaging used
  • Nature of lighting in the environment

What term is used to describe the cumulative bactericidal effect achieved by using formulation ingredients with intrinsic antimicrobial activity?

<p>Hurdle technology (A)</p> Signup and view all the answers

Which of the following is NOT a factor affecting the activity of antimicrobial agents on a given organism?

<p>Color of the challenge organism (A)</p> Signup and view all the answers

What can lead to the activation of latent ribonucleases and the consequent breakdown of RNA in cells?

<p>Depletion of intracellular potassium (B)</p> Signup and view all the answers

Which factor does NOT influence the activity of antimicrobial agents on a given population of organisms?

<p>Location of the challenge population (A)</p> Signup and view all the answers

What is the proposed outcome of the irreversible release of nucleotides and nucleosides from cells following an autolytic process induced by certain biocides?

<p>Autocidal process committing cells to death (C)</p> Signup and view all the answers

Which substances are examples of materials that may leak from treated cells, besides amino acids, purines, pyrimidines, and pentoses?

<p>Nucleotides and nucleosides (A)</p> Signup and view all the answers

What is the impact of a prolonged or low concentration action of a drug on cell leakage?

<p>Induction of bacteriostasis (C)</p> Signup and view all the answers

What is an autocidal (suicide) process in relation to cell death?

<p>Committing the injured cell to death (B)</p> Signup and view all the answers

What is a key strategy mentioned in the text to enhance the penetration of biocides to their target?

<p>Use of permeabilizing chelators (D)</p> Signup and view all the answers

Which type of antimicrobial drugs display an affinity for the negative charges of sugar residues on the microbial cell surface?

<p>Antimicrobial drugs whose active species is positively charged (B)</p> Signup and view all the answers

How do antimicrobial chemicals with a long alkyl chain disrupt the microbial cell?

<p>By integrating into the hydrophobic region of phospholipid molecules (B)</p> Signup and view all the answers

Which biocides are examples of oxidizing agents that can exert specific effects on essential microbial macromolecules?

<p>Chlorine, hypochlorites, bromine, iodophors (A)</p> Signup and view all the answers

What is the primary factor that affects the adsorption of biocides on the cell surface?

<p>The pH of the environment (C)</p> Signup and view all the answers

Which biocides are known to progress from early, sublethal events to multiple lesions of bactericidal consequence?

<p>Quaternary ammonium compounds (QACs) and chlorohexidine (A)</p> Signup and view all the answers

What are the three main factors to consider in evaluating the mechanism of action of a biocide?

<p>The initial health of the organism, the duration of contact with the biocide, and the concentration of biocide employed (A)</p> Signup and view all the answers

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