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Questions and Answers
What can induce an autoimmune disease in animals of some sensitive lines?
What can induce an autoimmune disease in animals of some sensitive lines?
- Injecting them with a certain autoantigen (correct)
- Removing certain epitopes from their system
- Exposing them to foreign antigens
- Injecting them with a pathogenic virus
What can happen when tissues are damaged due to a viral infection affecting a certain organ?
What can happen when tissues are damaged due to a viral infection affecting a certain organ?
- Reduction in the activation of lymphocytes
- Release of tissuespecific own antigens not normally present in significant quantities (correct)
- Decrease in the immune response
- Increase in the immunogen's epitopes
What may be a consequence of an autoimmune response spreading from the epitopes of a virus to the epitopes of its own tissue?
What may be a consequence of an autoimmune response spreading from the epitopes of a virus to the epitopes of its own tissue?
- Prevention of further autoimmune damage
- Decrease in the likelihood of chronic autoimmune destructive process
- Weakening of both the antiviral and autoimmune responses
- Transition of the antiviral immune response to an autoimmune response (correct)
What is a key factor in the development of a chronic autoimmune destructive process according to the text?
What is a key factor in the development of a chronic autoimmune destructive process according to the text?
Which scenario describes the epitopic spread concept mentioned in the text?
Which scenario describes the epitopic spread concept mentioned in the text?
What could cause the activation of lymphocytes specific to other epitopes of a protein or tissue?
What could cause the activation of lymphocytes specific to other epitopes of a protein or tissue?
What type of hypersensitivity reaction develops when immune complexes of autoantibodies with various nuclear antigens are deposited on the walls of small vessels?
What type of hypersensitivity reaction develops when immune complexes of autoantibodies with various nuclear antigens are deposited on the walls of small vessels?
What is the consequence of excessive complement activation in Systemic Lupus Erythematosus (SLE)?
What is the consequence of excessive complement activation in Systemic Lupus Erythematosus (SLE)?
What effect does C5a have on neutrophils in the context of SLE?
What effect does C5a have on neutrophils in the context of SLE?
What is the consequence of the aggregation of neutrophils on the walls of small blood vessels in SLE?
What is the consequence of the aggregation of neutrophils on the walls of small blood vessels in SLE?
What can lead to the occurrence of neutropenia in SLE?
What can lead to the occurrence of neutropenia in SLE?
What is the cause of glomerulonephritis in SLE?
What is the cause of glomerulonephritis in SLE?
What is the primary cause of Lyme disease?
What is the primary cause of Lyme disease?
Which components of Borrelia bacteria are most commonly associated with the induction of an autoimmune response in Lyme disease?
Which components of Borrelia bacteria are most commonly associated with the induction of an autoimmune response in Lyme disease?
Which mechanism is responsible for the breakdown of tolerance to its own antigens in Lyme disease?
Which mechanism is responsible for the breakdown of tolerance to its own antigens in Lyme disease?
Which hypothesis explains the initiation of autoimmune disease in Lyme disease?
Which hypothesis explains the initiation of autoimmune disease in Lyme disease?
Which immune components are involved in the pathogenesis of autoimmune arthritis in Lyme disease?
Which immune components are involved in the pathogenesis of autoimmune arthritis in Lyme disease?
Which immune response is triggered due to molecular mimicry in Lyme disease?
Which immune response is triggered due to molecular mimicry in Lyme disease?
What are the high levels of autoantibodies in AIDS patients often associated with?
What are the high levels of autoantibodies in AIDS patients often associated with?
What mechanism can provide costimulating signals for autoreactive lymphocytes?
What mechanism can provide costimulating signals for autoreactive lymphocytes?
Which cells most often act as antigen-presenting cells, activating autoreactive lymphocytes?
Which cells most often act as antigen-presenting cells, activating autoreactive lymphocytes?
What does the absence of specific mechanisms contributing to peripheral tolerance lead to?
What does the absence of specific mechanisms contributing to peripheral tolerance lead to?
Which molecules increase in expression on dendritic cells in infected tissue?
Which molecules increase in expression on dendritic cells in infected tissue?
What is presented on the surface of dendritic cells migrating to peripheral lymphoid organs?
What is presented on the surface of dendritic cells migrating to peripheral lymphoid organs?
What is a rare complication of measles vaccination?
What is a rare complication of measles vaccination?
Which virus shows a particularly high degree of homology with the main protein of myelin?
Which virus shows a particularly high degree of homology with the main protein of myelin?
What is the result of immunizing rabbits with a peptide from the hepatitis B virus?
What is the result of immunizing rabbits with a peptide from the hepatitis B virus?
What type of autoimmune response can be induced by infection with certain viruses?
What type of autoimmune response can be induced by infection with certain viruses?
What may also influence sensitivity to autoimmune reactions?
What may also influence sensitivity to autoimmune reactions?
What is a possible consequence of certain viruses expressing epitopes with molecular mimicry to the main myelin protein?
What is a possible consequence of certain viruses expressing epitopes with molecular mimicry to the main myelin protein?
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