Matrices, Genomics, Transcriptomics, Probability Quiz
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Questions and Answers

What is the role of regulatory elements in a gene?

  • To represent exons and introns
  • To produce proteins directly
  • To code for mRNA only
  • To initiate transcription and control gene expression (correct)
  • How do multiplex networks differ from multilayer networks?

  • They have different nodes in subnetworks.
  • They are not connected by edges.
  • They use the same nodes but different edges in subnetworks. (correct)
  • They can only have one type of edge.
  • What is a key difference between PCR and qPCR?

  • qPCR involves only one step while PCR has multiple.
  • PCR is used for RNA amplification, qPCR is not.
  • qPCR quantifies DNA while PCR does not. (correct)
  • Both techniques utilize the same thermal cycling conditions.
  • Which equation represents the relationship for independence in probability?

    <p>$P(EF) = P(E) imes P(F)$</p> Signup and view all the answers

    What is a primary feature of supervised learning in machine learning?

    <p>Predicting outcomes based on historical data.</p> Signup and view all the answers

    What does a node's degree in a network represent?

    <p>The number of edges connected to that node.</p> Signup and view all the answers

    What is the sample space in probability theory?

    <p>The set of all potential outcomes of an event.</p> Signup and view all the answers

    What is the purpose of multiple testing correction in probability?

    <p>To adjust for the increased chance of making Type I errors.</p> Signup and view all the answers

    Study Notes

    Matrices

    • The dimensions of matrices are important when multiplying them.
    • Matrices can be used to represent systems of equations and networks.

    Genomics

    • Parts of a gene include exons, introns, untranslated regions (UTRs), and regulatory elements such as promoters.
    • Genomics can be determined using next-generation sequencing or SNP arrays.

    Transcriptomics

    • PCR and qPCR are both techniques for amplifying DNA, but qPCR quantifies the amount of DNA present.
    • qPCR, microarrays, and RNAseq are all techniques for measuring gene expression, but they differ in their sensitivity, cost, and resolution.

    Probability

    • Sample space refers to all possible outcomes of a random event.
    • Types of probability distributions include the normal distribution, binomial distribution, and Poisson distribution, each used for different scenarios.
    • A statistic that quantifies the strength of the association between two events is the correlation coefficient.
    • Multiple testing correction helps to control the number of false positives in a statistical analysis.

    Independence

    • The probability of two events occurring together is equal to the product of their individual probabilities: P(EF) = P(E)P(F)

    Conditional Probabilities

    • Conditional probability represents the probability of an event E occurring given that event F has already occurred.
    • The formula for conditional probability is: P(E|F) = P(F|E)P(E) / P(F)

    Networks

    • Multilayer networks are composed of different networks connected by edges between subnetworks.
    • Multiplex networks have the same nodes but different edges in subnetworks.

    Networks (2)

    • Directed graphs have edges with a direction, indicating a relationship from one node to another. Undirected graphs have edges without a direction, representing a mutual relationship between nodes.
    • A node's degree represents the number of connections it has with other nodes in the network.
    • A network path is a sequence of connected nodes.
    • Networks can be used to model and understand biological concepts, such as protein interactions and gene regulation.

    Machine Learning

    • Classification is used to categorize data into predefined groups, while prediction aims to estimate a continuous value.
    • Feature selection can be done at three stages: preprocessing, during model training, and after model training.
    • Decision trees use a hierarchical structure to classify data based on a series of rules or conditions.
    • Supervised learning involves training a model on labeled data, while unsupervised learning uses unlabeled data to identify patterns.

    Mid-term Layout

    • Part 1: Knowledge-based questions worth 50 points, taken in-class.
    • Part 2: Critical review of a paper worth 50 points, due October 17th.

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    Description

    Test your knowledge across four key areas: matrices, genomics, transcriptomics, and probability. This quiz will challenge your understanding of fundamental concepts such as matrix multiplication, gene structure, gene expression techniques, and probability distributions. Perfect for students looking to solidify their grasp on these scientific topics.

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