Mastering Aminoglycosides
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Questions and Answers

Which of the following is NOT a recommended use for aminoglycosides according to the text?

  • CABP
  • cIAI
  • bacteremia/sepsis (correct)
  • cSSSI

Which aminoglycoside is commonly used as a secondary IV agent for tuberculosis?

  • Tobramycin
  • Gentamicin
  • Amikacin
  • Kanamycin (correct)

Which aminoglycoside has better anti-pseudomonal activity than gentamicin and amikacin?

  • Tobramycin (correct)
  • Amikacin
  • Gentamicin
  • Kanamycin

Which aminoglycoside is reserved for organisms resistant to other aminoglycosides?

<p>Amikacin (A)</p> Signup and view all the answers

Which aminoglycoside has a black box warning for teratogenicity in pregnancy?

<p>Gentamicin (A)</p> Signup and view all the answers

Which of the following is the mechanism of action for tetracyclines?

<p>Binds to 30s ribosomal subunit (C)</p> Signup and view all the answers

Which of the following adverse effects is associated with tetracyclines?

<p>Liver toxicity (C)</p> Signup and view all the answers

Which of the following antibiotics can be used for suppression therapy of methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA)?

<p>Tetracyclines (B)</p> Signup and view all the answers

Which antibiotic provides enhanced gram-negative coverage, covers vancomycin-resistant Enterococcus (VRE) and MRSA, but lacks coverage against Pseudomonas spp.?

<p>Tigecycline (C)</p> Signup and view all the answers

Which of the following is an adverse effect associated with minocycline?

<p>Staining and deformity of the teeth (D)</p> Signup and view all the answers

Which type of medications can increase neuromuscular blockade when used with aminoglycosides?

<p>Loop diuretics (A)</p> Signup and view all the answers

The aminoglycosides have excellent activity against which type of bacteria?

<p>Aerobic (B)</p> Signup and view all the answers

Aminoglycosides are used at synergistic doses along with cell wall active agents to treat which type of bacteria?

<p>Gram-positive (B)</p> Signup and view all the answers

What are the two major toxicities associated with the use of aminoglycosides?

<p>Ototoxicity and nephrotoxicity (D)</p> Signup and view all the answers

Which type of antibiotics can be inactivated by aminoglycosides?

<p>Penicillin G (A)</p> Signup and view all the answers

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