Antibiotics: Tetracyclines, Macrolides, and Aminoglycosides

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Questions and Answers

Which of the following statements accurately describes a key difference between aminoglycosides and tetracyclines?

  • Aminoglycosides are typically used to treat fungal infections, while tetracyclines are used for bacterial infections.
  • Tetracyclines primarily function by disrupting the bacterial cell wall, while aminoglycosides inhibit protein synthesis.
  • Tetracyclines are effective against aerobic gram-negative bacteria, while aminoglycosides are effective against anaerobic gram-positive bacteria.
  • Aminoglycosides are known for their potential toxicity and require careful monitoring, while tetracyclines are not recommended for children or pregnant women. (correct)

A patient presents with a penicillin-resistant infection. Which of the following medications would be the MOST appropriate choice, based on the information provided?

  • Clarithromycin (correct)
  • Gentamicin
  • Ciprofloxacin
  • Doxycycline

Which antibiotic class has a mechanism of action that directly inhibits the reproduction of microorganisms by interfering with protein synthesis?

  • Quinolones
  • Aminoglycosides
  • Macrolides (correct)
  • Tetracyclines

A patient is prescribed ciprofloxacin for a urinary tract infection (UTI). What potential side effect should the patient be advised to monitor for?

<p>Hallucinations (D)</p> Signup and view all the answers

Which of the following antibiotics is typically administered topically, intravenously, or as eye/ear drops?

<p>Neomycin (C)</p> Signup and view all the answers

Which of the following medications is characterized as being either bactericidal or bacteriostatic?

<p>Azithromycin (D)</p> Signup and view all the answers

A patient is diagnosed with gonorrhea. Based on the provided information, which of the following medications would be MOST appropriate to treat the patient's condition?

<p>Doxycycline (C)</p> Signup and view all the answers

Which class of antibiotics is known for its potential to cause a range of adverse effects, including dizziness, confusion, tremors, and hallucinations?

<p>Quinolones (D)</p> Signup and view all the answers

Which of the following statements accurately reflects a key property of tetracyclines?

<p>They exhibit effectiveness against both gram-negative and gram-positive bacteria. (A)</p> Signup and view all the answers

Which of the following aminoglycosides is NOT typically used to treat tuberculosis infections?

<p>Neomycin (D)</p> Signup and view all the answers

Flashcards

Tetracyclines

Class of antibiotics that generally prevent protein synthesis in bacteria, leading to growth inhibition between 1950-1960.

Doxycycline uses

Useful against both gram-negative and gram-positive organisms. Can treat gonorrhea, chlamydia, and anthrax.

Minocycline

A type of tetracycline that is useful against upper and lower respiratory tract infections.

Tetracycline action

General mechanism of action for tetracycline drugs.

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Macrolides like Erythromycin

Antibiotics that may exhibit resistance to penicillin.

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Azithromycin

Drug that inhibits reproduction of microorganisms by stopping protein synthesis. It can be bactericidal or bacteriostatic.

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Aminoglycosides

A group of antibiotics very toxic and effective against aerobic gram-negative bacteria, excluding Pseudomonas and tuberculosis.

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Neomycin route

Route of administration for neomycin.

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Ciprofloxacin

An anti-infective that is bacteriostatic.

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Oflaxacin Affect

Affects IV, PO, eye and URT. Side effects: dizziness, confusion, tremors, hallucinations, depression, allergic reaction, pain, muscle ache.

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Study Notes

  • Tetracyclines were introduced in 1950-1960 and prevent protein synthesis
  • Doxycycline is effective against Gram-negative and Gram-positive bacteria
  • It is also used to treat gonorrhea, chlamydia, and anthrax
  • Minocycline is used for community-acquired pneumonia (CAP)
  • Tetracycline is not recommended for children or pregnant women because it prevents protein synthesis

Macrolides

  • Erythromycin can be administered PO or IV
  • Clarithromycin is effective against infections resistant to penicillins and inhibits the reproduction of microorganisms by inhibiting protein synthesis
  • Azithromycin can be bactericidal or bacteriostatic and is effective at treating many infections

Aminoglycosides

  • Aminoglycosides are very toxic, it's important to monitor blood levels and kidney function
  • Amikacin and Paromomycin are effective against aerobic Gram-negative bacteria, including Pseudomonas and Tuberculosis
  • Gentamicin and Tobramycin are also Aminoglycosides
  • Kanamycin and Neomycin are Aminoglycosides used topically, IV, or as eye/ear drops

Quinolones

  • Quinolones are anti-infectives
  • Ciprofloxacin is bacteriostatic and is an FDA-DC medication
  • Ofloxacin can be administered IV, PO, or as eye drops and is used to treat UTIs
  • Side effects of Ofloxacin may include dizziness, confusion, tremors, hallucinations, depression, allergic reactions, pain, and muscle aches

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