Master the Regulation of Substrate Entry into the TCA Cycle
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Questions and Answers

Which molecule inhibits the PDH complex?

  • NADH (correct)
  • AMP
  • CoASH
  • NAD+

Which molecule inhibits citrate synthase?

  • Acetyl CoA
  • NADH
  • Citrate (correct)
  • Succinyl-CoA

Which molecules inhibit α-KGDH?

  • Citrate
  • NADH (correct)
  • Acetyl CoA
  • Succinyl-CoA

Which molecule is not involved in the activation of PDH complex?

<p>NADH (A)</p> Signup and view all the answers

Which molecule is not involved in the allosteric regulation of the TCA cycle?

<p>NADH (C)</p> Signup and view all the answers

Which molecule activates the PDH complex and inhibits citrate synthase?

<p>CoASH (B)</p> Signup and view all the answers

Which molecule inhibits the PDH complex?

<p>NADH (D)</p> Signup and view all the answers

Which molecule activates the PDH complex?

<p>CoASH (D)</p> Signup and view all the answers

Which molecule inhibits citrate synthase?

<p>Citrate (C)</p> Signup and view all the answers

Which molecule inhibits α-KGDH?

<p>NADH (C)</p> Signup and view all the answers

Which molecules regulate the key enzymes of the TCA cycle allosterically?

<p>Ca2+, ATP, ADP (A)</p> Signup and view all the answers

Which molecule is not involved in the activation of PDH complex?

<p>NADH (C)</p> Signup and view all the answers

Which molecule is not involved in the inhibition of PDH complex?

<p>Acetyl CoA (A)</p> Signup and view all the answers

Which molecule is not an inhibitor of α-KGDH?

<p>Acetyl CoA (A)</p> Signup and view all the answers

Which molecule is not an inhibitor of citrate synthase?

<p>Acetyl CoA (B)</p> Signup and view all the answers

Which molecule is not involved in the allosteric regulation of the TCA cycle?

<p>NADH (A)</p> Signup and view all the answers

Which molecule inhibits both α-KGDH and citrate synthase?

<p>NADH (A)</p> Signup and view all the answers

Which molecule activates the PDH complex and inhibits citrate synthase?

<p>CoASH (A)</p> Signup and view all the answers

Which molecule inhibits the PDH complex?

<p>Acetyl CoA (A)</p> Signup and view all the answers

What inhibits citrate synthase?

<p>Citrate (A)</p> Signup and view all the answers

What inhibits α-KGDH?

<p>NADH (C)</p> Signup and view all the answers

What activates the PDH complex?

<p>AMP (A)</p> Signup and view all the answers

What is the role of Ca2+ in the regulation of the TCA cycle?

<p>Activates key enzymes (D)</p> Signup and view all the answers

What is the role of ATP in the regulation of the TCA cycle?

<p>Inhibits key enzymes (D)</p> Signup and view all the answers

What is the role of ADP in the regulation of the TCA cycle?

<p>Activates key enzymes (D)</p> Signup and view all the answers

What activates the PDH complex in terms of NAD+/NADH ratio?

<p>Low NAD+ (A)</p> Signup and view all the answers

What inhibits α-KGDH in terms of NAD+/NADH ratio?

<p>High NADH (D)</p> Signup and view all the answers

What inhibits citrate synthase in terms of NAD+/NADH ratio?

<p>High NAD+ (D)</p> Signup and view all the answers

What activates the PDH complex in terms of the concentration of non acetylated CoA (CoASH)?

<p>High CoASH (B)</p> Signup and view all the answers

What activates the PDH complex in terms of the concentration of AMP?

<p>High AMP (D)</p> Signup and view all the answers

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