Master the Regulation of Substrate Entry into the TCA Cycle
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Questions and Answers

Which molecule inhibits the PDH complex?

  • NADH (correct)
  • AMP
  • CoASH
  • NAD+

    • Which molecule inhibits citrate synthase?

  • Acetyl CoA
  • NADH
  • Citrate (correct)
  • Succinyl-CoA

    • Which molecules inhibit α-KGDH?

  • Citrate
  • NADH (correct)
  • Acetyl CoA
  • Succinyl-CoA

    • Which molecule is not involved in the activation of PDH complex?

    <p>NADH</p> Signup and view all the answers

    Which molecule is not involved in the allosteric regulation of the TCA cycle?

    <p>NADH</p> Signup and view all the answers

    Which molecule activates the PDH complex and inhibits citrate synthase?

    <p>CoASH</p> Signup and view all the answers

    Which molecule inhibits the PDH complex?

    <p>NADH</p> Signup and view all the answers

    Which molecule activates the PDH complex?

    <p>CoASH</p> Signup and view all the answers

    Which molecule inhibits citrate synthase?

    <p>Citrate</p> Signup and view all the answers

    Which molecule inhibits α-KGDH?

    <p>NADH</p> Signup and view all the answers

    Which molecules regulate the key enzymes of the TCA cycle allosterically?

    <p>Ca2+, ATP, ADP</p> Signup and view all the answers

    Which molecule is not involved in the activation of PDH complex?

    <p>NADH</p> Signup and view all the answers

    Which molecule is not involved in the inhibition of PDH complex?

    <p>Acetyl CoA</p> Signup and view all the answers

    Which molecule is not an inhibitor of α-KGDH?

    <p>Acetyl CoA</p> Signup and view all the answers

    Which molecule is not an inhibitor of citrate synthase?

    <p>Acetyl CoA</p> Signup and view all the answers

    Which molecule is not involved in the allosteric regulation of the TCA cycle?

    <p>NADH</p> Signup and view all the answers

    Which molecule inhibits both α-KGDH and citrate synthase?

    <p>NADH</p> Signup and view all the answers

    Which molecule activates the PDH complex and inhibits citrate synthase?

    <p>CoASH</p> Signup and view all the answers

    Which molecule inhibits the PDH complex?

    <p>Acetyl CoA</p> Signup and view all the answers

    What inhibits citrate synthase?

    <p>Citrate</p> Signup and view all the answers

    What inhibits α-KGDH?

    <p>NADH</p> Signup and view all the answers

    What activates the PDH complex?

    <p>AMP</p> Signup and view all the answers

    What is the role of Ca2+ in the regulation of the TCA cycle?

    <p>Activates key enzymes</p> Signup and view all the answers

    What is the role of ATP in the regulation of the TCA cycle?

    <p>Inhibits key enzymes</p> Signup and view all the answers

    What is the role of ADP in the regulation of the TCA cycle?

    <p>Activates key enzymes</p> Signup and view all the answers

    What activates the PDH complex in terms of NAD+/NADH ratio?

    <p>Low NAD+</p> Signup and view all the answers

    What inhibits α-KGDH in terms of NAD+/NADH ratio?

    <p>High NADH</p> Signup and view all the answers

    What inhibits citrate synthase in terms of NAD+/NADH ratio?

    <p>High NAD+</p> Signup and view all the answers

    What activates the PDH complex in terms of the concentration of non acetylated CoA (CoASH)?

    <p>High CoASH</p> Signup and view all the answers

    What activates the PDH complex in terms of the concentration of AMP?

    <p>High AMP</p> Signup and view all the answers

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