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Master the Regulation of Smooth Muscle Contraction

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Master the Regulation of Smooth Muscle Contraction

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Questions and Answers

Which type of calcium channels are responsible for the influx of extracellular calcium in smooth muscle contraction?

Ryanodine receptors (RYRs)

Dihydropyridine receptors (DHPR) (correct)

L-type calcium channels

Calcium-gated calcium channels

What is the main role of ryanodine receptors (RYRs) in smooth muscle contraction?

Bind dihydropyridine class drugs

Release calcium from the sarcoplasmic reticulum (SR) (correct)

Release calcium from the cytosol

Mediate calcium entry during the action potential

Which source of calcium has a higher concentration in the cytosol and requires the entry of trigger calcium for its release?

Calcium released from the sarcoplasmic reticulum (SR) (correct)

Calcium-gated calcium channels

Dihydropyridine receptors (DHPR)

Extracellular calcium

Which event of excitation-contraction coupling in smooth muscle leads to the exposure of myosin binding sites on actin?

Release of calcium from the cisterns into the sarcoplasm Signup and view all the answers

What is the role of the Ca2+-ATPase pump (SERCA1 and SERCA2) in smooth muscle relaxation?

Sequestering calcium back into the sarcoplasmic reticulum (SR) Signup and view all the answers

How is calcium returned to the extracellular area in smooth muscle?

Via the sodium-calcium exchanger present in the T-tubules Signup and view all the answers

Which factor can increase the force of contraction in smooth muscle?

Beta-adrenergic stimulation Signup and view all the answers

What is positive lusitropy in smooth muscle?

Increase in the rate of muscle relaxation Signup and view all the answers

What type of smooth muscle contraction is sustained at a low energy expenditure?

Latch state Signup and view all the answers

Which of the following is a unique biophysical property of smooth muscle?

The length-tension relationship Signup and view all the answers

What is aganglionic megacolon or Hirschsprung's disease characterized by?

Lack of relaxation and movement of the affected segment of the colon Signup and view all the answers

Why is the load-velocity relationship slower in smooth muscle?

Due to the slow ATPase activity of smooth muscle myosin isoforms Signup and view all the answers