Fundamentals behind drug Regime Choice

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Which factor determines the loading dose of a drug?

Clearance

Half-life (correct)

Potency and efficacy

Absorption and distribution

What may be a reason for adjusting the dose of a drug to maintain therapeutic concentration?

Side effects

Drug to drug interactions

Dose-response relationships

Therapeutic window (correct)

What does dosage refer to?

The time it takes for a drug to reach steady state

The prescribed amount of medicine over time (correct)

The frequency of taking a drug

The route of administration

Which type of protein mainly binds to basic drugs?

Beta globulin Signup and view all the answers

Extensive protein binding slows drug elimination because...

the plasma is saturated with the drug Signup and view all the answers

What happens when the plasma is saturated with a drug?

Increased free drug levels Signup and view all the answers

Competition between drugs for protein binding sites can result in...

Increased drug interactions Signup and view all the answers

Which of the following is true about the loading dose?

It helps achieve steady-state concentrations earlier Signup and view all the answers

What determines the maintenance dose of a drug?

The drug's clearance Signup and view all the answers

What is the purpose of giving a drug multiple times during the day?

To maintain a constant drug level Signup and view all the answers

What happens to plasma concentrations at steady state in normal kinetics?

They increase proportionally with the dose Signup and view all the answers

What is the role of plasma protein binding in drug action?

It influences the drug's metabolism and excretion Signup and view all the answers

Which factor affects the bioavailability of a drug?

The degree of oral medication absorption Signup and view all the answers

What is the volume distribution of a drug?

The rate at which the drug is distributed to tissues Signup and view all the answers

Which factor can influence the onset of action of a drug?

The chemical structure and formulation of the drug Signup and view all the answers

Which route of administration allows a drug to enter circulation immediately?

Intravenous (IV) Signup and view all the answers

What is the role of plasma in drug pharmacokinetics?

To determine the bioavailability of the drug Signup and view all the answers

Which type of drug primarily binds to plasma albumin?

Acidic drugs Signup and view all the answers

What is the effect of extensive protein binding on drug elimination?

It slows drug elimination Signup and view all the answers

What happens when the plasma is saturated with a drug?

Increased free drug levels Signup and view all the answers

What is the potential consequence of competition between drugs for protein binding sites?

Drug interactions Signup and view all the answers

Which plasma protein primarily binds to basic drugs?

Beta globulin Signup and view all the answers

Which factor can affect the bioavailability of a drug?

The route of administration Signup and view all the answers

Which factor determines the volume distribution of a drug?

The degree of protein binding Signup and view all the answers

Which factor can influence the onset of action of a drug?

The chemical structure and formulation of the drug Signup and view all the answers

Which factor is NOT related to the clinical factors affecting drug regimen?

Tissue blood perfusion Signup and view all the answers

Which factor can alter the bioavailability of a drug?

The pH of the gastrointestinal tract Signup and view all the answers

Which of the following factors is NOT related to the determination of a drug regimen?

Pharmacokinetics Signup and view all the answers

What is the main purpose of a drug regimen in terms of drug concentration?

To maintain a steady state concentration Signup and view all the answers

Why is it important to escalate the dose of a drug in some cases?

To maintain therapeutic ability Signup and view all the answers

What is the definition of dosage in the context of drug regimens?

The amount of drug needed to elicit a response Signup and view all the answers

Which of the following scenarios is undesirable in a drug regimen?

A rapid increase in drug concentration leading to toxicity Signup and view all the answers

Which of the following is true about the steady state concentration (Css) of a drug in normal kinetics?

Css is directly proportional to the dose of the drug Signup and view all the answers

What is the main difference between normal kinetics and saturation kinetics?

In normal kinetics, Css increases proportionally with the dose, while in saturation kinetics, Css increases disproportionately with the dose Signup and view all the answers

What is the role of plasma protein binding in drug action?

Plasma protein binding helps to maintain a constant level of the drug in the plasma Signup and view all the answers

What determines the loading dose of a drug?

The volume distribution of the drug Signup and view all the answers

What is the purpose of administering a loading dose of a drug?

To achieve a steady state concentration (Css) immediately Signup and view all the answers

What is the impact of extensive protein binding on drug elimination?

Extensive protein binding slows drug elimination. Signup and view all the answers

Why does extensive protein binding slow drug elimination?

Because the plasma becomes saturated and the drug can no longer bind to it. Signup and view all the answers

What happens when the plasma is saturated with a drug?

Increased free drug levels occur. Signup and view all the answers

What does increased free drug levels lead to?

Increased distribution, metabolization, or excretion. Signup and view all the answers

Can competition between drugs for protein binding sites result in drug interactions?

Yes, but it is very uncommon. Signup and view all the answers

Which plasma protein primarily binds to acidic drugs?

Plasma albumin. Signup and view all the answers

Which plasma protein primarily binds to basic drugs?

Beta globulin. Signup and view all the answers

What is the potential consequence of competition between drugs for protein binding sites?

Drug interactions. Signup and view all the answers

What is the typical impact of drug interactions resulting from competition for protein binding sites?

Increased free drug levels. Signup and view all the answers

Does increased free drug levels affect drug distribution, metabolization, or excretion?

Yes, it can affect any of these processes. Signup and view all the answers

Fundamentals behind drug Regime Choice

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Questions and Answers

Which factor determines the loading dose of a drug?

What may be a reason for adjusting the dose of a drug to maintain therapeutic concentration?

What does dosage refer to?

Which type of protein mainly binds to basic drugs?

Extensive protein binding slows drug elimination because...

What happens when the plasma is saturated with a drug?

Competition between drugs for protein binding sites can result in...

Which of the following is true about the loading dose?

What determines the maintenance dose of a drug?

What is the purpose of giving a drug multiple times during the day?

What happens to plasma concentrations at steady state in normal kinetics?

What is the role of plasma protein binding in drug action?

Which factor affects the bioavailability of a drug?

What is the volume distribution of a drug?

Which factor can influence the onset of action of a drug?

Which route of administration allows a drug to enter circulation immediately?

What is the role of plasma in drug pharmacokinetics?

Which type of drug primarily binds to plasma albumin?

What is the effect of extensive protein binding on drug elimination?

What happens when the plasma is saturated with a drug?

What is the potential consequence of competition between drugs for protein binding sites?

Which plasma protein primarily binds to basic drugs?

Which factor can affect the bioavailability of a drug?

Which factor determines the volume distribution of a drug?

Which factor can influence the onset of action of a drug?

Which factor is NOT related to the clinical factors affecting drug regimen?

Which factor can alter the bioavailability of a drug?

Which of the following factors is NOT related to the determination of a drug regimen?

What is the main purpose of a drug regimen in terms of drug concentration?

Why is it important to escalate the dose of a drug in some cases?

What is the definition of dosage in the context of drug regimens?

Which of the following scenarios is undesirable in a drug regimen?

Which of the following is true about the steady state concentration (Css) of a drug in normal kinetics?

What is the main difference between normal kinetics and saturation kinetics?

What is the role of plasma protein binding in drug action?

What determines the loading dose of a drug?

What is the purpose of administering a loading dose of a drug?

What is the impact of extensive protein binding on drug elimination?

Why does extensive protein binding slow drug elimination?

What happens when the plasma is saturated with a drug?

What does increased free drug levels lead to?

Can competition between drugs for protein binding sites result in drug interactions?

Which plasma protein primarily binds to acidic drugs?

Which plasma protein primarily binds to basic drugs?

What is the potential consequence of competition between drugs for protein binding sites?

What is the typical impact of drug interactions resulting from competition for protein binding sites?

Does increased free drug levels affect drug distribution, metabolization, or excretion?

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