Fundamentals behind drug Regime Choice
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Questions and Answers

Which factor determines the loading dose of a drug?

  • Clearance
  • Half-life (correct)
  • Potency and efficacy
  • Absorption and distribution

    • What may be a reason for adjusting the dose of a drug to maintain therapeutic concentration?

  • Side effects
  • Drug to drug interactions
  • Dose-response relationships
  • Therapeutic window (correct)

    • What does dosage refer to?

  • The time it takes for a drug to reach steady state
  • The prescribed amount of medicine over time (correct)
  • The frequency of taking a drug
  • The route of administration

    • Which type of protein mainly binds to basic drugs?

    <p>Beta globulin</p> Signup and view all the answers

    Extensive protein binding slows drug elimination because...

    <p>the plasma is saturated with the drug</p> Signup and view all the answers

    What happens when the plasma is saturated with a drug?

    <p>Increased free drug levels</p> Signup and view all the answers

    Competition between drugs for protein binding sites can result in...

    <p>Increased drug interactions</p> Signup and view all the answers

    Which of the following is true about the loading dose?

    <p>It helps achieve steady-state concentrations earlier</p> Signup and view all the answers

    What determines the maintenance dose of a drug?

    <p>The drug's clearance</p> Signup and view all the answers

    What is the purpose of giving a drug multiple times during the day?

    <p>To maintain a constant drug level</p> Signup and view all the answers

    What happens to plasma concentrations at steady state in normal kinetics?

    <p>They increase proportionally with the dose</p> Signup and view all the answers

    What is the role of plasma protein binding in drug action?

    <p>It influences the drug's metabolism and excretion</p> Signup and view all the answers

    Which factor affects the bioavailability of a drug?

    <p>The degree of oral medication absorption</p> Signup and view all the answers

    What is the volume distribution of a drug?

    <p>The rate at which the drug is distributed to tissues</p> Signup and view all the answers

    Which factor can influence the onset of action of a drug?

    <p>The chemical structure and formulation of the drug</p> Signup and view all the answers

    Which route of administration allows a drug to enter circulation immediately?

    <p>Intravenous (IV)</p> Signup and view all the answers

    What is the role of plasma in drug pharmacokinetics?

    <p>To determine the bioavailability of the drug</p> Signup and view all the answers

    Which type of drug primarily binds to plasma albumin?

    <p>Acidic drugs</p> Signup and view all the answers

    What is the effect of extensive protein binding on drug elimination?

    <p>It slows drug elimination</p> Signup and view all the answers

    What happens when the plasma is saturated with a drug?

    <p>Increased free drug levels</p> Signup and view all the answers

    What is the potential consequence of competition between drugs for protein binding sites?

    <p>Drug interactions</p> Signup and view all the answers

    Which plasma protein primarily binds to basic drugs?

    <p>Beta globulin</p> Signup and view all the answers

    Which factor can affect the bioavailability of a drug?

    <p>The route of administration</p> Signup and view all the answers

    Which factor determines the volume distribution of a drug?

    <p>The degree of protein binding</p> Signup and view all the answers

    Which factor can influence the onset of action of a drug?

    <p>The chemical structure and formulation of the drug</p> Signup and view all the answers

    Which factor is NOT related to the clinical factors affecting drug regimen?

    <p>Tissue blood perfusion</p> Signup and view all the answers

    Which factor can alter the bioavailability of a drug?

    <p>The pH of the gastrointestinal tract</p> Signup and view all the answers

    Which of the following factors is NOT related to the determination of a drug regimen?

    <p>Pharmacokinetics</p> Signup and view all the answers

    What is the main purpose of a drug regimen in terms of drug concentration?

    <p>To maintain a steady state concentration</p> Signup and view all the answers

    Why is it important to escalate the dose of a drug in some cases?

    <p>To maintain therapeutic ability</p> Signup and view all the answers

    What is the definition of dosage in the context of drug regimens?

    <p>The amount of drug needed to elicit a response</p> Signup and view all the answers

    Which of the following scenarios is undesirable in a drug regimen?

    <p>A rapid increase in drug concentration leading to toxicity</p> Signup and view all the answers

    Which of the following is true about the steady state concentration (Css) of a drug in normal kinetics?

    <p>Css is directly proportional to the dose of the drug</p> Signup and view all the answers

    What is the main difference between normal kinetics and saturation kinetics?

    <p>In normal kinetics, Css increases proportionally with the dose, while in saturation kinetics, Css increases disproportionately with the dose</p> Signup and view all the answers

    What is the role of plasma protein binding in drug action?

    <p>Plasma protein binding helps to maintain a constant level of the drug in the plasma</p> Signup and view all the answers

    What determines the loading dose of a drug?

    <p>The volume distribution of the drug</p> Signup and view all the answers

    What is the purpose of administering a loading dose of a drug?

    <p>To achieve a steady state concentration (Css) immediately</p> Signup and view all the answers

    What is the impact of extensive protein binding on drug elimination?

    <p>Extensive protein binding slows drug elimination.</p> Signup and view all the answers

    Why does extensive protein binding slow drug elimination?

    <p>Because the plasma becomes saturated and the drug can no longer bind to it.</p> Signup and view all the answers

    What happens when the plasma is saturated with a drug?

    <p>Increased free drug levels occur.</p> Signup and view all the answers

    What does increased free drug levels lead to?

    <p>Increased distribution, metabolization, or excretion.</p> Signup and view all the answers

    Can competition between drugs for protein binding sites result in drug interactions?

    <p>Yes, but it is very uncommon.</p> Signup and view all the answers

    Which plasma protein primarily binds to acidic drugs?

    <p>Plasma albumin.</p> Signup and view all the answers

    Which plasma protein primarily binds to basic drugs?

    <p>Beta globulin.</p> Signup and view all the answers

    What is the potential consequence of competition between drugs for protein binding sites?

    <p>Drug interactions.</p> Signup and view all the answers

    What is the typical impact of drug interactions resulting from competition for protein binding sites?

    <p>Increased free drug levels.</p> Signup and view all the answers

    Does increased free drug levels affect drug distribution, metabolization, or excretion?

    <p>Yes, it can affect any of these processes.</p> Signup and view all the answers

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