LESSON 17 multiple Lymphoid Organs: Lymph Nodes

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What is the main function of lymph nodes in the lymphatic system?

To filter lymph and facilitate the response of lymphocytes to antigens

What is the composition of the stroma in a lymph node?

Reticular fibres, reticular cells, capsule, and trabeculae

What structures separate the parenchyma from the capsule and trabeculae in a lymph node?

Lymphatic sinuses

What is the shape of lymph nodes?

Ovoid or kidney-shaped

What type of vessels enter the lymph node through the capsule at various intervals on its convex surface?

Afferent lymphatic vessels

What do the afferent lymphatic vessels flow into upon entering the lymph node?

Subcapsular sinus

What prevents the lymph from going back in the afferent and efferent lymphatic vessels?

Valves

What is the supportive framework of the lymphatic sinuses made up of?

Reticular cells and fibres

Where are high endothelial venules (HEV) located within the lymph node?

Cortical parenchyma

What do high endothelial venules (HEV) lack?

Muscular layer

Which vessels are the port of entry into the lymph node for lymphocytes carried by the blood?

Capillaries

What is the structure of the pig lymph nodes like compared to other species?

They have several nodular units with central medullary tissue and wide medullary sinuses.

What kind of cells are observed in the lumen of the medullary sinuses?

T cells, B cells, and macrophages

What is located in the outer region of the cortex of a lymph node?

Lymphoid follicles and interfollicular areas

What elements facilitate the interaction between antigens with macrophages and dendritic cells?

Macrophages and dendritic cells

What do the lymphatic sinuses allow filtering into the parenchyma?

Substances in solution, particles in suspension, and cells

What is the specific function of the lymph nodes' microenvironment?

Filtering antigens from lymph

What is the composition of the lymph node stroma primarily made up of?

Type III collagen and reticular cells

What separates the parenchyma from the capsule and trabeculae in a lymph node?

Lymphatic sinuses

What is the shape of the lymph nodes?

Oval or kidney-shaped

What is the shape of the lymphatic sinuses in the medulla of a lymph node?

Irregular

Where do the medullary sinuses drain the efferent lymphatic vessels in pig lymph nodes?

Spaces between the nodular units

What is the composition of the cords in the medulla of a lymph node?

T cells, B cells, plasma cells, and macrophages

What is the structure of the medullary tissue distribution in pig lymph nodes?

Around the periphery of the nodular units and around the efferent hilum

Where are high endothelial venules (HEV) located within the lymph node?

In the interfollicular area and paracortex

What is the main function of high endothelial venules (HEV) in a lymph node?

To allow entry of lymphocytes carried by the blood

What prevents backflow of lymph in both afferent and efferent lymphatic vessels?

Valves

What do dendritic cells and macrophages located in the wall of medullary sinuses facilitate?

Interaction between antigens and immune cells

What is located in the outer region of the cortex of a lymph node?

Lymphoid follicles and interfollicular areas

What type of vessels carry lymphocytes into the parenchyma of a lymph node from primary lymphoid organs or blood recirculation?

Postcapillary venules

What is the supportive framework of the lymphatic sinuses made up of?

Reticular cells and fibres

Learn about the structure and function of lymph nodes, which are secondary lymphoid organs distributed along the lymphatic vessels. Understand their parenchyma and connective tissue stroma, as well as the entry and exit points for arteries, veins, and lymphatic vessels.

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