7 Questions
Which of the following is NOT a step involved in the development of lymphocytes from bone marrow stem cells?
Proliferation of hematopoietic progenitors
Where do B lymphocytes mature?
Bone marrow
What stimulates the survival and proliferation of the earliest lymphocyte precursors?
Growth factors produced by stromal cells in the bone marrow
Which process ensures that only T cells capable of recognizing microbial peptides displayed by MHC molecules on APCs survive and proliferate?
Positive selection
What is the main function of IL-7 in humans?
To maintain and expand the number of T lymphocyte progenitors
What is the purpose of negative selection in lymphocyte development?
To eliminate strongly self-reactive B and T lymphocytes
What happens to immature T cells that fail to express antigen receptor proteins?
They die by apoptosis
Quiz: The Development of Lymphocytes and Antigen Receptor Genes Test your knowledge on the development of lymphocytes from bone marrow stem cells. Learn about the commitment of hematopoietic progenitors to the B or T cell lineage, the rearrangement and expression of antigen receptor genes, and selection events that preserve and expand cells with useful antigen receptors. Find out how these steps are common to both B and T lymphocytes.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
