Lymphocyte Development & Antigen Receptor Genes Quiz
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Questions and Answers

Which of the following is NOT a step involved in the development of lymphocytes from bone marrow stem cells?

  • Commitment to the B or T cell lineage
  • Proliferation of hematopoietic progenitors (correct)
  • Selection events to preserve and expand cells with useful antigen receptors
  • Rearrangement and expression of antigen receptor genes

    • Where do B lymphocytes mature?

  • Lymph nodes
  • Spleen
  • Bone marrow (correct)
  • Thymus

    • What stimulates the survival and proliferation of the earliest lymphocyte precursors?

  • Growth factors produced by stromal cells in the bone marrow (correct)
  • Cytokines produced by T lymphocytes
  • Growth factors produced by stromal cells in the thymus
  • Cytokines produced by B lymphocytes

    • Which process ensures that only T cells capable of recognizing microbial peptides displayed by MHC molecules on APCs survive and proliferate?

    <p>Positive selection</p> Signup and view all the answers

    What is the main function of IL-7 in humans?

    <p>To maintain and expand the number of T lymphocyte progenitors</p> Signup and view all the answers

    What is the purpose of negative selection in lymphocyte development?

    <p>To eliminate strongly self-reactive B and T lymphocytes</p> Signup and view all the answers

    What happens to immature T cells that fail to express antigen receptor proteins?

    <p>They die by apoptosis</p> Signup and view all the answers

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