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Questions and Answers
Which of the following is NOT a step involved in the development of lymphocytes from bone marrow stem cells?
Which of the following is NOT a step involved in the development of lymphocytes from bone marrow stem cells?
- Commitment to the B or T cell lineage
- Proliferation of hematopoietic progenitors (correct)
- Selection events to preserve and expand cells with useful antigen receptors
- Rearrangement and expression of antigen receptor genes
Where do B lymphocytes mature?
Where do B lymphocytes mature?
- Lymph nodes
- Spleen
- Bone marrow (correct)
- Thymus
What stimulates the survival and proliferation of the earliest lymphocyte precursors?
What stimulates the survival and proliferation of the earliest lymphocyte precursors?
- Growth factors produced by stromal cells in the bone marrow (correct)
- Cytokines produced by T lymphocytes
- Growth factors produced by stromal cells in the thymus
- Cytokines produced by B lymphocytes
Which process ensures that only T cells capable of recognizing microbial peptides displayed by MHC molecules on APCs survive and proliferate?
Which process ensures that only T cells capable of recognizing microbial peptides displayed by MHC molecules on APCs survive and proliferate?
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What is the main function of IL-7 in humans?
What is the main function of IL-7 in humans?
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What is the purpose of negative selection in lymphocyte development?
What is the purpose of negative selection in lymphocyte development?
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What happens to immature T cells that fail to express antigen receptor proteins?
What happens to immature T cells that fail to express antigen receptor proteins?
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