Leukopoiesis: Development and Maturation of Leukocytes
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Questions and Answers

What is the characteristic of eosinophils when stained?

  • They take on a deep blue color
  • They take on a deep eosin color (correct)
  • They take on a deep red color
  • They take on a deep green color

    • What is the primary function of eosinophils in the body?

  • To phagocytose bacteria
  • To participate in defense against certain parasites (correct)
  • To produce toxins
  • To produce antibodies

    • What is eosinophilia?

  • A transient increase in eosinophil count (correct)
  • A sustained decrease in eosinophil count
  • A permanent increase in eosinophil count
  • A decrease in eosinophil count

    • What is unique about the granules of eosinophils?

    <p>They contain cytotoxic substances</p> Signup and view all the answers

    What is the approximate percentage of circulating leukocytes that eosinophils make up?

    <p>1-3%</p> Signup and view all the answers

    What happens to the eosinophil count in individuals infected with parasites?

    <p>It increases sustainedly</p> Signup and view all the answers

    How do eosinophils attack parasites?

    <p>By releasing cytotoxic substances</p> Signup and view all the answers

    What is a characteristic of eosinophils compared to neutrophils?

    <p>They are less motile</p> Signup and view all the answers

    What is the color of the granules in Polymorphonuclear Eosinophils when stained with eosin?

    <p>Pink or red</p> Signup and view all the answers

    What is the shape of the nucleus in Polymorphonuclear Eosinophils?

    <p>Bilobed</p> Signup and view all the answers

    What is the diameter of Polymorphonuclear Eosinophils?

    <p>10 to 14 µ</p> Signup and view all the answers

    What type of granules do Polymorphonuclear Eosinophils have?

    <p>Coarse</p> Signup and view all the answers

    What is the function of Colony Stimulating Factors (CSF) in leukopoiesis?

    <p>To cause the formation of colony forming blastocytes</p> Signup and view all the answers

    Which of the following types of leukocytes have granules in their cytoplasm?

    <p>Granulocytes</p> Signup and view all the answers

    What type of leukocyte is Polymorphonuclear Eosinophils?

    <p>Granulocyte</p> Signup and view all the answers

    Which of the following factors is NOT involved in leukopoiesis?

    <p>Interferon</p> Signup and view all the answers

    What is the function of Eosinophil peroxidase released by eosinophils?

    <p>To destroy parasites or foreign proteins</p> Signup and view all the answers

    Which of the following is NOT a component of eosinophil granules?

    <p>Myeloperoxidase</p> Signup and view all the answers

    What is the function of cytokines released by eosinophils?

    <p>To modulate the immune response</p> Signup and view all the answers

    What is the primary function of eosinophils?

    <p>To destroy parasites or foreign proteins</p> Signup and view all the answers

    Which of the following is a component of eosinophil granules?

    <p>Eosinophil-derived neurotoxin</p> Signup and view all the answers

    What is the effect of cytokines released by basophils on regional blood flow?

    <p>It increases regional blood flow</p> Signup and view all the answers

    What is the role of eosinophils in the immune response?

    <p>To destroy parasites or foreign proteins</p> Signup and view all the answers

    What is the function of Major basic protein (MBP) released by eosinophils?

    <p>To destroy parasites or foreign proteins</p> Signup and view all the answers

    Study Notes

    White Blood Cells (WBCs) and Infection

    • WBCs fight against bacteria, but many are killed by toxins released from the invaders, resulting in a whitish yellow fluid called pus.
    • Pus is formed in infected tissue, consisting of dead cells, plasma leaked from blood vessels, liquefied tissue cells, and RBCs that escaped from damaged blood vessels.

    Neutrophils

    • Contain enzymes like proteases, myeloperoxidases, elastases, metalloproteinases, and antibody-like peptides called cathelicidins and defensins.

    Eosinophils

    • Make up 1-3% of circulating leukocytes and are easily identified on stained blood films.
    • Contain granules that stain orange-red to bright yellow during polychromatic staining.
    • Migrate to sites where they are needed and exhibit a metabolic burst when activated.
    • Participate in defense against certain parasites and are involved in allergic reactions.
    • Release cytotoxic substances that are lethal to parasites, including eosinophil peroxidase, major basic protein, eosinophil cationic protein, and cytokines.

    Basophils

    • Are polymorphonuclear leukocytes with multiple pleomorphic, coarse, deep-staining metachromatic granules.
    • Granules contain heparin, histamine, proteases, myeloperoxidase, and cytokines with anticoagulant, vasodilating, cytotoxic, and inflammatory properties.
    • Play an important role in healing processes, and their number increases during the healing process.

    Monocytes

    • Are primarily involved in the immune response against bacterial infection and make up roughly 5-10% of all circulating leukocytes.
    • Differentiate into macrophages, which form the main population of phagocytic cells within tissues.
    • Macrophages phagocytose microorganisms, digest them, and secrete cytokines that modulate the immune response.

    Leukopoiesis

    • Is the development and maturation of leukocytes, influenced by hemopoietic growth factors and colony stimulating factors.
    • Colony stimulating factors (CSF) are proteins that cause the formation of colony-forming blastocytes.

    Types of White Blood Cells

    • Leukocytes are classified into two groups based on the presence or absence of granules in the cytoplasm: Granulocytes (with granules) and Agranulocytes (without granules).
    • The five types of leukocytes are:
      • Polymorphonuclear Neutrophils
      • Polymorphonuclear Eosinophils
      • Polymorphonuclear Basophils
      • Monocytes
      • Lymphocytes (not mentioned in the text)

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    PHS 203 EKSU PHYSIOLOGY notes.docx

    Description

    Learn about the process of leukopoiesis, including the factors that influence it, such as hemopoietic growth factors and colony stimulating factors. Understand the different types of colony stimulating factors and their roles.

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