Leukocyte Migration Quiz
14 Questions
4 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which cytokines initiate the sequence of events in leukocyte migration into tissues?

  • IL-4 and IL-10
  • IL-6 and IL-8
  • IFN and IL-2
  • TNF and IL-1 (correct)

    • Which adhesion molecule of the selectin family is expressed by venular endothelial cells in response to TNF and IL-1?

  • E-selectin (correct)
  • P-selectin
  • L-selectin
  • Integrin

    • What is the multistep process of leukocyte migration from the blood into tissues?

  • Transmigration followed by weak adhesive interactions and then firm adhesion
  • Weak adhesive interactions followed by transmigration and then firm adhesion
  • Weak adhesive interactions followed by firm adhesion and then transmigration (correct)
  • Firm adhesion followed by transmigration and then weak adhesive interactions

    • What is the role of chemokines in leukocyte migration?

    <p>Chemokines direct the migration of leukocytes along extracellular matrix fibers</p> Signup and view all the answers

    What is the function of integrins in leukocyte adhesion?

    <p>Integrins mediate firm adhesion of leukocytes to the endothelium</p> Signup and view all the answers

    What is the sequence of events that leads to leukocyte migration to an extravascular site of infection?

    <p>Selectin-mediated rolling, integrin-mediated firm adhesion, chemokine-mediated motility</p> Signup and view all the answers

    What is the consequence of inherited deficiencies in integrins and selectin ligands?

    <p>Increased susceptibility to infections</p> Signup and view all the answers

    Which adhesion molecule of the selectin family is translocated to the endothelial surface in response to stimuli such as thrombin?

    <p>P-selectin</p> Signup and view all the answers

    Which cells recognize and respond to infectious microbes by producing cytokines?

    <p>Dendritic cells</p> Signup and view all the answers

    What is the carbohydrate-binding property of selectins referred to as?

    <p>Lectin</p> Signup and view all the answers

    What is the function of chemokines in leukocyte migration?

    <p>Chemokines stimulate the increase in affinity of leukocyte integrins for their ligands on the endothelium.</p> Signup and view all the answers

    What is the role of selectins in leukocyte migration?

    <p>Selectins mediate the rolling of leukocytes along the endothelial surface.</p> Signup and view all the answers

    What is the consequence of leukocyte adhesion deficiencies (LADs)?

    <p>Increased susceptibility to infections.</p> Signup and view all the answers

    What is the function of plasma proteins in leukocyte migration?

    <p>Plasma proteins provide defense against the pathogens.</p> Signup and view all the answers

    Study Notes

    Leukocyte Migration

    • Cytokines TNF and IL-1 initiate the sequence of events in leukocyte migration into tissues.
    • The adhesion molecule P-selectin, expressed by venular endothelial cells in response to TNF and IL-1, plays a key role in leukocyte migration.

    Multistep Process of Leukocyte Migration

    • The multistep process of leukocyte migration from the blood into tissues involves:
      • Rolling and tethering of leukocytes on the endothelial surface
      • Activation and integrin-mediated firm adhesion
      • Transmigration across the endothelial layer
      • Migration through the tissues to the site of infection

    Role of Chemokines and Integrins

    • Chemokines are responsible for directing leukocytes to the site of infection and activating them to migrate across the endothelial layer.
    • Integrins are essential for leukocyte adhesion, as they enable firm binding to the endothelial surface.

    Sequence of Events Leading to Leukocyte Migration

    • The sequence of events leading to leukocyte migration to an extravascular site of infection is:
      • Recognition of infectious microbes by immune cells
      • Production of cytokines (TNF and IL-1) by immune cells
      • Expression of P-selectin by venular endothelial cells
      • Rolling and tethering of leukocytes on the endothelial surface
      • Activation and integrin-mediated firm adhesion
      • Transmigration across the endothelial layer
      • Migration through the tissues to the site of infection

    Consequences of Deficiencies

    • Inherited deficiencies in integrins and selectin ligands lead to impaired leukocyte migration and increased susceptibility to infection.
    • Leukocyte adhesion deficiencies (LADs) result in impaired leukocyte migration, leading to recurrent infections and inflammatory disorders.

    Additional Key Facts

    • The carbohydrate-binding property of selectins is referred to as lectin activity.
    • Thrombin is a stimulus that can induce translocation of P-selectin to the endothelial surface.
    • Plasma proteins, such as fibronectin and vitronectin, play a role in leukocyte migration by providing a substrate for integrin-mediated adhesion.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Test your knowledge on the multistep process of leukocyte migration from blood to tissues with this quiz. Topics include adhesion molecules, chemoattractants, and interaction with endothelial cells.

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser