Podcast
Questions and Answers
Which cytokines initiate the sequence of events in leukocyte migration into tissues?
Which cytokines initiate the sequence of events in leukocyte migration into tissues?
Which adhesion molecule of the selectin family is expressed by venular endothelial cells in response to TNF and IL-1?
Which adhesion molecule of the selectin family is expressed by venular endothelial cells in response to TNF and IL-1?
What is the multistep process of leukocyte migration from the blood into tissues?
What is the multistep process of leukocyte migration from the blood into tissues?
What is the role of chemokines in leukocyte migration?
What is the role of chemokines in leukocyte migration?
Signup and view all the answers
What is the function of integrins in leukocyte adhesion?
What is the function of integrins in leukocyte adhesion?
Signup and view all the answers
What is the sequence of events that leads to leukocyte migration to an extravascular site of infection?
What is the sequence of events that leads to leukocyte migration to an extravascular site of infection?
Signup and view all the answers
What is the consequence of inherited deficiencies in integrins and selectin ligands?
What is the consequence of inherited deficiencies in integrins and selectin ligands?
Signup and view all the answers
Which adhesion molecule of the selectin family is translocated to the endothelial surface in response to stimuli such as thrombin?
Which adhesion molecule of the selectin family is translocated to the endothelial surface in response to stimuli such as thrombin?
Signup and view all the answers
Which cells recognize and respond to infectious microbes by producing cytokines?
Which cells recognize and respond to infectious microbes by producing cytokines?
Signup and view all the answers
What is the carbohydrate-binding property of selectins referred to as?
What is the carbohydrate-binding property of selectins referred to as?
Signup and view all the answers
What is the function of chemokines in leukocyte migration?
What is the function of chemokines in leukocyte migration?
Signup and view all the answers
What is the role of selectins in leukocyte migration?
What is the role of selectins in leukocyte migration?
Signup and view all the answers
What is the consequence of leukocyte adhesion deficiencies (LADs)?
What is the consequence of leukocyte adhesion deficiencies (LADs)?
Signup and view all the answers
What is the function of plasma proteins in leukocyte migration?
What is the function of plasma proteins in leukocyte migration?
Signup and view all the answers
Study Notes
Leukocyte Migration
- Cytokines TNF and IL-1 initiate the sequence of events in leukocyte migration into tissues.
- The adhesion molecule P-selectin, expressed by venular endothelial cells in response to TNF and IL-1, plays a key role in leukocyte migration.
Multistep Process of Leukocyte Migration
- The multistep process of leukocyte migration from the blood into tissues involves:
- Rolling and tethering of leukocytes on the endothelial surface
- Activation and integrin-mediated firm adhesion
- Transmigration across the endothelial layer
- Migration through the tissues to the site of infection
Role of Chemokines and Integrins
- Chemokines are responsible for directing leukocytes to the site of infection and activating them to migrate across the endothelial layer.
- Integrins are essential for leukocyte adhesion, as they enable firm binding to the endothelial surface.
Sequence of Events Leading to Leukocyte Migration
- The sequence of events leading to leukocyte migration to an extravascular site of infection is:
- Recognition of infectious microbes by immune cells
- Production of cytokines (TNF and IL-1) by immune cells
- Expression of P-selectin by venular endothelial cells
- Rolling and tethering of leukocytes on the endothelial surface
- Activation and integrin-mediated firm adhesion
- Transmigration across the endothelial layer
- Migration through the tissues to the site of infection
Consequences of Deficiencies
- Inherited deficiencies in integrins and selectin ligands lead to impaired leukocyte migration and increased susceptibility to infection.
- Leukocyte adhesion deficiencies (LADs) result in impaired leukocyte migration, leading to recurrent infections and inflammatory disorders.
Additional Key Facts
- The carbohydrate-binding property of selectins is referred to as lectin activity.
- Thrombin is a stimulus that can induce translocation of P-selectin to the endothelial surface.
- Plasma proteins, such as fibronectin and vitronectin, play a role in leukocyte migration by providing a substrate for integrin-mediated adhesion.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge on the multistep process of leukocyte migration from blood to tissues with this quiz. Topics include adhesion molecules, chemoattractants, and interaction with endothelial cells.
