Laxatives Mechanism of Action Quiz

Play an AI-generated podcast conversation about this lesson

What is the definition of constipation?

Having a bowel movement every day

Having a bowel movement exactly 3 times per week

Having a bowel movement at least 3 times per week

Having a bowel movement less than 3 times per week (correct)

Which of the following is NOT a cause of constipation as mentioned in the text?

Ignoring the urge to have a bowel movement

Decreased physical activity

Excessive physical activity (correct)

Diet low in fiber and inadequate fluid intake

Which of the following is considered a metabolic and endocrine disorder that can lead to constipation?

Irritable bowel syndrome (IBS)

Anal fissures

Hemorrhoids

Diabetes mellitus with neuropathy (correct)

What is the recommended first-line treatment for constipation according to the text?

Non-pharmacological treatment including a diet rich in fibers Signup and view all the answers

Which of the following is NOT a class of drugs that can contribute to constipation?

Antibiotics Signup and view all the answers

Which neurological condition can be associated with neurogenic constipation according to the text?

Head trauma Signup and view all the answers

Which type of laxative works by retaining water in the gut and distending the large intestine?

Bulk-forming agents Signup and view all the answers

What is a potential adverse effect of bulk-forming agents?

Intestinal obstruction Signup and view all the answers

Which osmotic laxative may produce hypermagnesemia and hypernatremia in patients with renal failure?

Mg sulfate & Na salts Signup and view all the answers

What is the onset of action for osmotic laxatives like Polyethylene glycol?

24-72 hours Signup and view all the answers

How do bulk-forming agents stimulate peristalsis?

By retaining water in the gut and distending the large intestine Signup and view all the answers

Which laxative type works by their osmotic effect to activate stretch receptors and stimulate peristalsis?

Osmotic laxatives Signup and view all the answers

Which of the following laxatives would be most appropriate for an infant or child?

Polyethylene glycol (PEG) Signup and view all the answers

What is the laxative of choice for pregnant women?

Bisacodyl Signup and view all the answers

Which drug is most suitable for long-term use as a laxative?

Lactulose Signup and view all the answers

What is the drug of choice for Diabetic gastroparesis?

Metoclopramide Signup and view all the answers

Which antihypertensive drug would be contraindicated in a patient with insulin-dependent diabetes, IBS, and HTN?

Both A & B Signup and view all the answers

When using lubricant laxatives, which of the following is NOT considered a lubricant laxative?

Docusate Signup and view all the answers

Which laxative produces inflammation of the intestinal mucosa and inhibits Na+/K+ ATPase enzyme?

Castor oil Signup and view all the answers

What is the mechanism of action for Lubiprostone and Linaclotide?

Activating chloride channels Signup and view all the answers

Which laxative takes effect within 15—60 minutes after rectal administration?

Docusate sodium Signup and view all the answers

What is the approved use for Lubiprostone (Amitiza)?

Chronic idiopathic constipation and constipation-predominant IBS-C in adults Signup and view all the answers

What is the onset of action for stool softeners like Docusate sodium after oral administration?

12-72 hours Signup and view all the answers

Which laxative acts by easing the passage of stool through activating chloride channels?

Liquid paraffin Signup and view all the answers