Laxatives: Types and Mechanisms

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Questions and Answers

Which type of laxative works by drawing water into the intestines to increase the osmotic pressure?

  • Saline (correct)
  • Hyperosmotic
  • Emollient
  • Bulk forming

A patient taking an opioid pain medication is experiencing severe constipation. Which of the following medications would be most appropriate and directly address the cause?

  • Polyethylene glycol
  • Docusate sodium (Colace)
  • Methylnaltrexone (Relistor) (correct)
  • Senna (Senokot)

Which laxative is also used to reduce elevated serum ammonia levels?

  • Mineral oil
  • Bisacodyl
  • Psyllium
  • Lactulose (correct)

A patient with renal insufficiency is prescribed a laxative. Which type of laxative should the nurse question?

<p>Saline (D)</p> Signup and view all the answers

A patient reports chronic constipation and wants to use a bulk-forming laxative. What crucial instruction should be given to this patient?

<p>Increase fluid intake to prevent impaction. (C)</p> Signup and view all the answers

Which laxative type could potentially interfere with the absorption of fat-soluble vitamins?

<p>Emollient (B)</p> Signup and view all the answers

A patient is scheduled for a diagnostic bowel procedure. Which class of laxatives is often used for bowel preparation before such procedures?

<p>Stimulant (D)</p> Signup and view all the answers

A patient with a history of irritable bowel syndrome (IBS) is seeking a laxative for their constipation. Which of the following would be most appropriate?

<p>Psyllium (A)</p> Signup and view all the answers

What is a common adverse effect associated with stimulant laxatives that patients should be aware of?

<p>Nutrient malabsorption (B)</p> Signup and view all the answers

Which of the following is the mechanism of action of emollient laxatives?

<p>Promoting more water and fat in the stools (A)</p> Signup and view all the answers

What is the primary mechanism of action of bulk-forming laxatives?

<p>Absorbing water to increase bulk and distend the bowel. (B)</p> Signup and view all the answers

A patient reports discolored urine after starting a new laxative. Which type of laxative is most likely responsible for this side effect?

<p>Stimulant (C)</p> Signup and view all the answers

A patient is experiencing nausea, vomiting, and abdominal pain. What is the most appropriate initial action regarding laxative use?

<p>Consult a healthcare provider before administering any laxative. (C)</p> Signup and view all the answers

Which of the following laxative types is most likely to cause impaction if not taken with sufficient fluids?

<p>Bulk forming (A)</p> Signup and view all the answers

What is the primary mechanism of action of saline laxatives?

<p>Increasing osmotic pressure in the intestinal tract (B)</p> Signup and view all the answers

Which type of laxative is best suited for short-term relief of constipation, rather than long-term management?

<p>Stimulant (D)</p> Signup and view all the answers

A patient is diagnosed with fecal impaction. Which type of laxative may be used to help manage this condition?

<p>Emollient (B)</p> Signup and view all the answers

Which adverse effect is most closely associated with hyperosmotic laxative use?

<p>Abdominal bloating (A)</p> Signup and view all the answers

Which of the following is a contraindication or precaution to consider before administering a saline laxative?

<p>Renal insufficiency (D)</p> Signup and view all the answers

What baseline assessment is most important for the nurse to complete before initiating any type of laxative therapy?

<p>Fluid and electrolyte status (A)</p> Signup and view all the answers

Flashcards

Bulk-forming laxatives

High-fibre substances that absorb water, increasing bulk and stimulating bowel activity.

Emollient laxatives

Laxatives that promote water and fat incorporation into stools, softening them and lubricating the intestinal walls.

Hyperosmotic laxatives

Laxatives that increase fecal water content, leading to bowel distention and evacuation.

Saline laxatives

Laxatives that increase osmotic pressure in the intestinal tract, drawing water into the intestines.

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Stimulant laxatives

Laxatives that stimulate intestinal peristalsis through nerve stimulation.

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Bulk forming laxative uses

Used for acute and chronic constipation, irritable bowel syndrome and diverticulosis.

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Emollient laxative uses

Used for acute and chronic constipation, fecal impaction and anorectal conditions.

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Hyperosmotic laxative uses

Used for chronic constipation and preparation for diagnostic/surgical procedures.

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Saline Laxative Uses

Used for constipation and preparation for diagnostic/surgical procedures.

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Opioid Antagonists

Peripherally Acting Opioid Antagonists block opioid entrance into the bowel, allowing normal bowel function with continued opioid use.

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Stimulant Laxative Uses

Used for acute constipation and preparation for diagnostic/surgical procedures.

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Bulk-forming laxative adverse effects

Can cause impaction, fluid overload, electrolyte imbalances, gas formation, esophageal blockage, and allergic reactions.

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Emollient laxatives adverse effects

Can cause skin rashes, decreased vitamin absorption, electrolyte imbalances, and lipid pneumonia.

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Hyperosmotic Laxative Adverse Effects

Can cause abdominal bloating, electrolyte imbalances and rectal irritation.

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Saline Laxative Adverse Effects

Can cause magnesium toxicity, cramping, electrolyte imbalances, diarrhea and increased thirst.

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Stimulant Laxative Adverse Effects

Can cause nutrient malabsorption, skin rashes, gastric irritation, electrolyte imbalances, discoloured urine and rectal irritation.

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Laxative Nursing Implications

Includes obtaining thorough history, assessing fluid and electrolytes, and informing patients not to take if nauseous, vomiting or have abdominal pain.

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Study Notes

  • Laxatives are categorized into bulk forming, emollient, hyperosmotic, saline, and stimulant types.

Laxatives: Mechanism of Action

  • Bulk forming laxatives are high in fiber, absorb water to increase bulk, and distend the bowel to initiate reflex bowel activity.
  • Psyllium (Metamucil®) and methylcellulose are examples of bulk-forming laxatives.
  • Emollient laxatives act as stool softeners and lubricants, promoting more water and fat in the stools and lubricating the fecal material and intestinal walls.
  • Docusate salts (Colace®) are stool softeners, while mineral oil is a lubricant.
  • Hyperosmotic laxatives increase fecal water content, leading to bowel distention, increased peristalsis, and evacuation.
  • Polyethylene glycol, sorbitol, glycerin, and lactulose are examples of hyperosmotic laxatives. Lactulose is also used to reduce elevated serum ammonia levels.
  • Saline laxatives increase osmotic pressure within the intestinal tract, causing more water to enter the intestines, resulting in bowel distention, increased peristalsis, and evacuation.
  • Magnesium hydroxide (Milk of Magnesia®) and magnesium citrate are saline laxatives.
  • Stimulant laxatives increase peristalsis via intestinal nerve stimulation.
  • Senna (Senokot®) and bisacodyl (Dulcolax®) are examples of stimulant laxatives.

Peripherally Acting Opioid Antagonists

  • Peripherally acting opioid antagonists treat constipation related to opioid use and bowel resection therapy, blocking the entrance of opioids into the bowel.
  • These antagonists, such as methylnaltrexone (Relistor®) and alvimopan (Entereg®), allow the bowel to function normally with continued opioid use.

Laxatives: Indications

  • Bulk-forming laxatives are used for acute and chronic constipation, irritable bowel syndrome, and diverticulosis.
  • Emollient laxatives are indicated for acute and chronic constipation, fecal impaction, and facilitation of bowel movements in anorectal conditions.
  • Hyperosmotic laxatives are used for chronic constipation and diagnostic and surgical procedures.
  • Saline laxatives are used for constipation and diagnostic and surgical procedures.
  • Stimulant laxatives are used for acute constipation and diagnostic and surgical procedures.

Laxatives: Adverse Effects

  • Bulk forming laxatives may cause impaction, fluid overload, electrolyte imbalances, gas formation, esophageal blockage, and allergic reaction.
  • Emollient laxatives may cause skin rashes, decreased absorption of vitamins, electrolyte imbalances, and lipid pneumonia.
  • Hyperosmotic laxatives may cause abdominal bloating, electrolyte imbalances, and rectal irritation.
  • Saline laxatives may cause magnesium toxicity (with renal insufficiency), cramping, and increased thirst.
  • Stimulant laxatives may cause nutrient malabsorption, skin rashes, gastric irritation, electrolyte imbalances, discolored urine, and rectal irritation.
  • All laxatives can cause electrolyte imbalances.

Laxatives: Nursing Implications

  • Obtain a thorough history of presenting symptoms, elimination patterns, and allergies before initiating laxative therapy.
  • Assess fluid and electrolytes before initiating therapy.
  • Patients experiencing nausea, vomiting, or abdominal pain should not take laxatives.

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