12 Questions
What is the location where lactate dehydrogenase operates?
Cytoplasm
What are the substrates for lactate dehydrogenase?
Pyruvate and Coenzyme NADH
Which type of polypeptide subunit is found in cancer cells?
K (submit)
What determines the relative percentage of aerobic and anaerobic pathways in cells?
Kinetic properties of each enzyme type
In which type of cells is LDHk found?
Photoreceptors and cancer cells
How does LDH influence corneal epithelial cells under low partial pressures of oxygen?
Promotes anaerobic metabolism
In human cornea, which LDH isozyme has the highest percentage?
HM3
What is the influence of LDHk M4 on the retina due to its modification?
Increases oxygen sensitivity
Which enzyme catalyzes the conversion of glucose to sorbitol and galactose to galactitol in certain disease conditions?
Aldose reductase
What factor causes the activation of aldose reductase in the lens in diabetes?
High glucose or galactose concentration
What is the primary impact of polyols like sorbitol and galactitol on lens fiber cells?
Induce cell swelling and bursting
What type of sites are present on aldose reductase enzyme, particularly the inhibitory site?
Lipophilic
Learn about lactate dehydrogenase, its operation at the metabolic junction of aerobic and anaerobic metabolism, and its location in the cytoplasm of all eukaryotic cells. Explore the substrates for lactate dehydrogenase and the conversion of pyruvate to lactate.
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