(T1): Drug treatment of Type 2 Diabetes Mellitus

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which route of administration involves considering bioavailability, absorption phase, elimination phase, average serum concentration, maximum safe concentration, therapeutic range, minimum effective concentration, and duration of action of the drug?

Local delivery

Systemic delivery (correct)

Intramuscular injections

Transdermal delivery systems

What type of delivery offers rapid onset of action, requires less drug, and avoids unwanted side effects associated with systemic absorption?

Transdermal delivery systems

Intranasal administration

Local delivery (correct)

Systemic delivery

Which route of administration is suitable for low molecular weight compounds due to its large surface area, highly vascularized area, and avoidance of first-pass hepatic metabolism?

Intramuscular injections

Vaginal administration

Intranasal administration (correct)

Inhaled delivery

Which type of hormones are not absorbed after oral administration and are administered systemically to mimic normal secretion?

Peptide hormones Signup and view all the answers

Which route of administration is used for systemic delivery of large surface area drugs, such as inhaled insulin, to avoid the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism?

Pulmonary route Signup and view all the answers

What type of delivery aims to avoid systemic side effects when administering corticosteroids?

Local delivery Signup and view all the answers

Which type of hormones have variable absorption after oral administration and extensive first-pass hepatic metabolism, requiring alternatives to the oral route for systemic delivery?

Sex hormones Signup and view all the answers

What type of administration offers sustained release of drugs like testosterone through intramuscular injections and implants?

Parenteral routes Signup and view all the answers

Which route of administration involves various dosage forms such as gels, pessaries, tablets, rings, and intrauterine systems for continuous release and good patient compliance?

Vaginal administration Signup and view all the answers

Which hormones are administered locally through vaginal gel or pessary/tablet for a specific action of ripening the cervix?

Eicosanoid hormones Signup and view all the answers

Which hormones can be administered through various routes for systemic and local delivery?

Modified amino acid derivatives, peptides and proteins, steroids, and eicosanoids Signup and view all the answers

Which type of hormones are characterized by differences in onset, peak, and duration, and are not absorbed after oral administration?

Peptide hormones Signup and view all the answers

Which factor affects the oral delivery of hormones and modification of formulations, such as sustained release?

Solubility of the drug Signup and view all the answers

Which route of administration is suitable for systemic delivery of large surface area drugs, such as inhaled insulin, to avoid the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism?

Nasal administration Signup and view all the answers

Why do we have different dosage/medicinal forms?

All of the above Signup and view all the answers

What type of delivery aims to avoid systemic side effects when administering corticosteroids?

Transdermal delivery Signup and view all the answers

Which type of hormones are characterized by differences in onset, peak, and duration, and are not absorbed after oral administration?

Peptide hormones Signup and view all the answers

Which route of administration involves considering bioavailability, absorption phase, elimination phase, average serum concentration, maximum safe concentration, therapeutic range, minimum effective concentration, and duration of action of the drug?

Oral administration Signup and view all the answers

Which hormones are not absorbed after oral administration and are administered systemically to mimic normal secretion?

Thyroid hormones Signup and view all the answers

Which route of administration involves various dosage forms such as gels, pessaries, tablets, rings, and intrauterine systems for continuous release and good patient compliance?

Vaginal administration Signup and view all the answers

Which type of administration offers sustained release of drugs like testosterone through intramuscular injections and implants?

Intramuscular injection Signup and view all the answers

Which route of administration is used for systemic delivery of low molecular weight compounds due to its large surface area, highly vascularized area, and avoidance of first-pass hepatic metabolism?

Nasal administration Signup and view all the answers

Which factor is crucial in affecting the oral delivery of hormones and modification of formulations such as sustained release?

Particle size of solid drug Signup and view all the answers

Which route of administration is suitable for systemic delivery of large surface area drugs, such as inhaled insulin, to avoid the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism?

Nasal administration Signup and view all the answers

Which type of hormones are not absorbed after oral administration and are administered systemically to mimic normal insulin secretion?

Peptides and proteins Signup and view all the answers

Which route of administration is used for systemic delivery of large surface area drugs, such as inhaled insulin, to avoid the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism?

Intranasal Signup and view all the answers

Which type of hormones have variable absorption after oral administration and extensive first-pass hepatic metabolism, requiring alternatives to the oral route for systemic delivery?

Steroids Signup and view all the answers

Which type of hormones are characterized by differences in onset, peak, and duration, and are not absorbed after oral administration?

Peptides and proteins Signup and view all the answers

Which route of administration offers sustained release of drugs like testosterone through intramuscular injections and implants?

Parenteral Signup and view all the answers

What type of delivery aims to avoid systemic side effects when administering corticosteroids?

Local delivery Signup and view all the answers

Which route of administration involves various dosage forms such as gels, pessaries, tablets, rings, and intrauterine systems for continuous release and good patient compliance?

Vaginal Signup and view all the answers

Which route of administration involves considering bioavailability, absorption phase, elimination phase, average serum concentration, maximum safe concentration, therapeutic range, minimum effective concentration, and duration of action of the drug?

Systemic delivery Signup and view all the answers

Which route of administration is suitable for low molecular weight compounds due to its large surface area, highly vascularized area, and avoidance of first-pass hepatic metabolism?

Intranasal Signup and view all the answers

Which type of hormones are administered locally through vaginal gel or pessary/tablet for a specific action of ripening the cervix?

Eicosanoids Signup and view all the answers

Which route of administration is used for systemic delivery of large surface area drugs, such as inhaled insulin, to avoid the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism?

Intranasal Signup and view all the answers

Study Notes

Systemic and Local Delivery of Hormones and Drugs

Hormones can be administered systemically through various routes such as modified amino acid derivatives (e.g., dopamine, levothyroxine), peptides and proteins (e.g., neuropeptides, pituitary hormones), steroids (e.g., sex hormones, corticosteroids), and eicosanoids (e.g., prostaglandins).
Systemic delivery involves considering the bioavailability, absorption phase, elimination phase, average serum concentration, maximum safe concentration, therapeutic range, minimum effective concentration, and duration of action of the drug.
Local delivery of drugs offers rapid onset of action, requires less drug, and avoids unwanted side effects associated with systemic absorption.
Local delivery of corticosteroids involves various dosage forms such as intra-articular injections, creams, ointments, inhalers, eye drops, and suppositories, aiming to avoid systemic side effects.
Peptide hormones like insulin, characterized by differences in onset, peak, and duration, are not absorbed after oral administration and are administered systemically to mimic normal insulin secretion.
The pulmonary route is used for systemic delivery of large surface area drugs, such as inhaled insulin, which avoids the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism.
Systemic delivery of sex hormones, which have variable absorption after oral administration and extensive first-pass hepatic metabolism, requires alternatives to the oral route such as parenteral, transdermal, intranasal, buccal, and vaginal routes.
Parenteral routes such as intramuscular injections and implants offer sustained release of drugs like testosterone, while transdermal delivery systems offer systemic absorption of estradiol.
Advantages of intranasal administration include a large surface area, highly vascularized area, and avoidance of first-pass hepatic metabolism, which is suitable for low molecular weight compounds.
Vaginal administration, either systemic or local, involves various dosage forms such as gels, pessaries, tablets, rings, and intrauterine systems, offering continuous release and good patient compliance.
Eicosanoid hormones, like prostaglandin E2, are administered locally through vaginal gel or pessary/tablet for a specific action of ripening the cervix.
Different types of hormones, including modified amino acid derivatives, peptides and proteins, steroids, and eicosanoids, can be administered through various routes for systemic and local delivery.

Systemic and Local Delivery of Hormones and Drugs

Hormones can be administered systemically through various routes such as modified amino acid derivatives (e.g., dopamine, levothyroxine), peptides and proteins (e.g., neuropeptides, pituitary hormones), steroids (e.g., sex hormones, corticosteroids), and eicosanoids (e.g., prostaglandins).
Systemic delivery involves considering the bioavailability, absorption phase, elimination phase, average serum concentration, maximum safe concentration, therapeutic range, minimum effective concentration, and duration of action of the drug.
Local delivery of drugs offers rapid onset of action, requires less drug, and avoids unwanted side effects associated with systemic absorption.
Local delivery of corticosteroids involves various dosage forms such as intra-articular injections, creams, ointments, inhalers, eye drops, and suppositories, aiming to avoid systemic side effects.
Peptide hormones like insulin, characterized by differences in onset, peak, and duration, are not absorbed after oral administration and are administered systemically to mimic normal insulin secretion.
The pulmonary route is used for systemic delivery of large surface area drugs, such as inhaled insulin, which avoids the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism.
Systemic delivery of sex hormones, which have variable absorption after oral administration and extensive first-pass hepatic metabolism, requires alternatives to the oral route such as parenteral, transdermal, intranasal, buccal, and vaginal routes.
Parenteral routes such as intramuscular injections and implants offer sustained release of drugs like testosterone, while transdermal delivery systems offer systemic absorption of estradiol.
Advantages of intranasal administration include a large surface area, highly vascularized area, and avoidance of first-pass hepatic metabolism, which is suitable for low molecular weight compounds.
Vaginal administration, either systemic or local, involves various dosage forms such as gels, pessaries, tablets, rings, and intrauterine systems, offering continuous release and good patient compliance.
Eicosanoid hormones, like prostaglandin E2, are administered locally through vaginal gel or pessary/tablet for a specific action of ripening the cervix.
Different types of hormones, including modified amino acid derivatives, peptides and proteins, steroids, and eicosanoids, can be administered through various routes for systemic and local delivery.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

(T1): Drug treatment of Type 2 Diabetes Mellitus

Choose a study mode

Podcast

Questions and Answers

Which route of administration involves considering bioavailability, absorption phase, elimination phase, average serum concentration, maximum safe concentration, therapeutic range, minimum effective concentration, and duration of action of the drug?

What type of delivery offers rapid onset of action, requires less drug, and avoids unwanted side effects associated with systemic absorption?

Which route of administration is suitable for low molecular weight compounds due to its large surface area, highly vascularized area, and avoidance of first-pass hepatic metabolism?

Which type of hormones are not absorbed after oral administration and are administered systemically to mimic normal secretion?

Which route of administration is used for systemic delivery of large surface area drugs, such as inhaled insulin, to avoid the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism?

What type of delivery aims to avoid systemic side effects when administering corticosteroids?

Which type of hormones have variable absorption after oral administration and extensive first-pass hepatic metabolism, requiring alternatives to the oral route for systemic delivery?

What type of administration offers sustained release of drugs like testosterone through intramuscular injections and implants?

Which route of administration involves various dosage forms such as gels, pessaries, tablets, rings, and intrauterine systems for continuous release and good patient compliance?

Which hormones are administered locally through vaginal gel or pessary/tablet for a specific action of ripening the cervix?

Which hormones can be administered through various routes for systemic and local delivery?

Which type of hormones are characterized by differences in onset, peak, and duration, and are not absorbed after oral administration?

Which factor affects the oral delivery of hormones and modification of formulations, such as sustained release?

Which route of administration is suitable for systemic delivery of large surface area drugs, such as inhaled insulin, to avoid the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism?

Why do we have different dosage/medicinal forms?

What type of delivery aims to avoid systemic side effects when administering corticosteroids?

Which type of hormones are characterized by differences in onset, peak, and duration, and are not absorbed after oral administration?

Which route of administration involves considering bioavailability, absorption phase, elimination phase, average serum concentration, maximum safe concentration, therapeutic range, minimum effective concentration, and duration of action of the drug?

Which hormones are not absorbed after oral administration and are administered systemically to mimic normal secretion?

Which route of administration involves various dosage forms such as gels, pessaries, tablets, rings, and intrauterine systems for continuous release and good patient compliance?

Which type of administration offers sustained release of drugs like testosterone through intramuscular injections and implants?

Which route of administration is used for systemic delivery of low molecular weight compounds due to its large surface area, highly vascularized area, and avoidance of first-pass hepatic metabolism?

Which factor is crucial in affecting the oral delivery of hormones and modification of formulations such as sustained release?

Which route of administration is suitable for systemic delivery of large surface area drugs, such as inhaled insulin, to avoid the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism?

Which type of hormones are not absorbed after oral administration and are administered systemically to mimic normal insulin secretion?

Which route of administration is used for systemic delivery of large surface area drugs, such as inhaled insulin, to avoid the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism?

Which type of hormones have variable absorption after oral administration and extensive first-pass hepatic metabolism, requiring alternatives to the oral route for systemic delivery?

Which type of hormones are characterized by differences in onset, peak, and duration, and are not absorbed after oral administration?

Which route of administration offers sustained release of drugs like testosterone through intramuscular injections and implants?

What type of delivery aims to avoid systemic side effects when administering corticosteroids?

Which route of administration involves various dosage forms such as gels, pessaries, tablets, rings, and intrauterine systems for continuous release and good patient compliance?

Which route of administration involves considering bioavailability, absorption phase, elimination phase, average serum concentration, maximum safe concentration, therapeutic range, minimum effective concentration, and duration of action of the drug?

Which route of administration is suitable for low molecular weight compounds due to its large surface area, highly vascularized area, and avoidance of first-pass hepatic metabolism?

Which type of hormones are administered locally through vaginal gel or pessary/tablet for a specific action of ripening the cervix?

Which route of administration is used for systemic delivery of large surface area drugs, such as inhaled insulin, to avoid the harsh environment of the gastrointestinal tract and first-pass hepatic metabolism?

Study Notes

Studying That Suits You

Related Documents

More Like This

T1 L3: Synaptic transmission

T1 L4: Chemicals in the brain

T1 L7: Neuropathology

T1. Introducción: Historia y Enfoque General (Medio)