canine pathology
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Questions and Answers

What characterizes the enteritis observed in dogs older than 15 days?

  • Acute lymphocytosis
  • Increased villi density
  • Lymphoid hyperplasia
  • Crypt hyperplasia (correct)

Which of the following clinical signs is associated with infectious canine hepatitis?

  • Swollen lymph nodes
  • Diarrhea
  • Corneal edema (correct)
  • Hair loss

What type of myocarditis is noted in infectious canine hepatitis?

  • Fibrotic myocarditis
  • Eosinophilic myocarditis
  • Necroheamorrhagic myocarditis (correct)
  • Lymphocytic myocarditis

What histopathological feature is indicative of severe enteritis in dogs?

<p>Villar blunting (C)</p> Signup and view all the answers

Which virus is responsible for infectious canine hepatitis?

<p>Adenovirus 1 (A)</p> Signup and view all the answers

What is the primary cause of leukopenia in dogs with infectious canine hepatitis?

<p>Viral replication in white blood cells (A)</p> Signup and view all the answers

What is one notable lesion found in the liver of dogs with infectious canine hepatitis?

<p>Jaundice due to hepatocyte injury (C)</p> Signup and view all the answers

What is a common feature noted in the small intestine of pups affected by necrotizing enteritis?

<p>Acute villous atrophy (C)</p> Signup and view all the answers

What is a common symptom associated with diffuse hemorrhagic diathesis?

<p>Loss of appetite (B)</p> Signup and view all the answers

What laboratory test is primarily used to assess clotting factors?

<p>Coagulation tests (C)</p> Signup and view all the answers

What is a consequence of widespread endothelial damage in terms of clotting?

<p>Accelerated consumption of clotting factors (B)</p> Signup and view all the answers

Which imaging technique may be used to observe an enlarged liver?

<p>Ultrasound (C)</p> Signup and view all the answers

What condition is associated with the presence of intranuclear inclusion bodies in the liver?

<p>Diffuse hemorrhagic hepatitis (A)</p> Signup and view all the answers

What is a potential post-recovery complication observed in some dogs after treatment for hemorrhagic conditions?

<p>Immune complex glomerulonephritis (A)</p> Signup and view all the answers

Which of the following symptoms is least likely to occur with hemorrhagic conditions?

<p>Increased appetite (D)</p> Signup and view all the answers

What describes the type of liver damage seen in severe, acute diffuse centrilobular to midzonal bridging hepatic necrosis?

<p>Severe acute destruction (B)</p> Signup and view all the answers

What is a common clinical sign of hemorrhagic gastroenteritis?

<p>Bloody diarrhea (C)</p> Signup and view all the answers

Which lesion is typical of hemorrhagic gastroenteritis?

<p>Segmental lesion on the small intestine (B)</p> Signup and view all the answers

What is the pathogenesis related to the cardiac form of this disease?

<p>Lymphocytic myocarditis (D)</p> Signup and view all the answers

What causes death in puppies with hemorrhagic gastroenteritis?

<p>Severe dehydration (C)</p> Signup and view all the answers

What is a specific diagnosis indicator for hemorrhagic gastroenteritis?

<p>High PCV (A)</p> Signup and view all the answers

Which clinical sign is NOT typically associated with hemorrhagic gastroenteritis?

<p>Skin rash (B)</p> Signup and view all the answers

Which of the following describes the appearance of lesions in hemorrhagic gastroenteritis?

<p>Dark red hemorrhage (D)</p> Signup and view all the answers

What is a common finding on histopathological examination of this disease?

<p>Intranuclear inclusion bodies (C)</p> Signup and view all the answers

Flashcards

Hemorrhagic Gastroenteritis (HGE)

A severe intestinal infection in dogs marked by bloody diarrhea, vomiting, and abdominal pain. The condition is especially common in young pups.

Segmental Lesions

A distinguishing feature of HGE, appearing as dark red, segmental lesions with hemorrhage on the small intestine.

Necrosis

The presence of dead tissue in the intestinal wall in HGE.

Fibrinonecrotising Enteritis

The presence of fibrin, a protein involved in blood clotting, in the intestine, forming a whitish-yellow, sticky layer alongside dead tissue.

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Intranuclear Inclusion Bodies

Tiny, dark spots found within the nuclei of intestinal cells, indicating infection with a virus.

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Cardiac Form of HGE

A form of HGE that affects the heart, characterized by inflammation of the heart muscle (myocarditis) and lymphocytic infiltration.

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High PCV

An abnormally high packed cell volume (PCV) in the blood, indicating dehydration, a common symptom of HGE.

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In Situ Hybridization

A method of identifying viral RNA in the intestinal cells, confirming the presence of a viral infection.

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Infectious Canine Hepatitis (ICH)

A highly contagious viral disease in dogs caused by canine adenovirus type 1. It primarily affects the liver and can lead to severe complications.

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Necroheamorrhagic myocarditis

A type of inflammation of the heart muscle characterized by the death of heart cells, often caused by viral infections.

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Hepatitis

A condition where the liver cells become inflamed and damaged, often due to infection.

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Corneal edema

An abnormal accumulation of fluid in the cornea of the eye, often seen as a clouding or haziness, that can occur due to inflammation or other medical conditions.

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Leukopenia

A condition characterized by a decrease in the number of white blood cells, often caused by viral or bacterial infections.

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Jaundice

The clinical sign of yellowing of the skin and whites of the eyes, often indicative of liver dysfunction.

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Gall Bladder Cholangitis

An inflammatory condition of the gall bladder, often associated with viral infections.

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Viral enteritis

A viral infection affecting the small intestine, characterized by inflammation and tissue damage.

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Hepatic Necrosis

The presence of dead tissue in the liver tissue, characteristically observed in cases of ICH.

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Study Notes

Hemorrhagic Gastroenteritis

  • Lesions: Segmental lesions on small intestine, characterized by dark red hemorrhage (distended small intestine) and transmural necrohemorrhagic enteritis. Segmental lesions with dark pink/fibrosis and distended small intestine, segmental fibrinonecrotizing enteritis are also noted. Intranuclear inclusion bodies are present in columnar epithelial cell nuclei.

  • Clinical Signs: Bloody diarrhea, vomiting, abdominal pain, lethargy, loss of appetite, dehydration, fever, and collapse are common.

  • Pathogenesis/Causes: Generalized necrosis of various organs, often fatal within 10 days, is a common characteristic of this condition.

  • Diagnosis: PCV (packed cell volume) is a key diagnostic metric, with values of >55% being highly suggestive of hemorrhagic gastroenteritis (HGE).

Infectious Canine Hepatitis

  • Lesions: Characterized by diffuse atrophy of the heart, with dark red petechial hemorrhage. Multifocal to coalescing necrohemorrhagic myocarditis (heart tissue damage) is seen. Corneal edema and leukopenia may occur. Gall bladder colitis, enlarged liver, and hemorrhagic hepatitis are also indicative of the infection.

  • Clinical Signs: Fever, jaundice, depression, loss of appetite, vomiting, abdominal pain, coughing, and exhaustion are frequent clinical signs.

  • Pathogenesis/Causes: Inflammatory responses led by adenovirus or similar viruses may cause generalized hemorrhages. Widespread damage to endothelial cells initiates a cascade of events that leads to accelerated consumption of clotting factors possibly associated with a disseminated intravascular coagulation (DIC) process.

  • Diagnosis: A full blood count (complete blood count) alongside coagulation tests are recommended. Ultrasound scans to assess liver enlargement and liver biopsies may also be necessary.

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