Canine Pathology PDF

Disease What does it look like Lesions Clinical signs Pathogenesis/causes Diagnosis Heamorrhagic - segmental lesion on small intestine - bloody diarrhoea - generalised - h...

Disease What does it look like Lesions Clinical signs Pathogenesis/causes Diagnosis Heamorrhagic - segmental lesion on small intestine - bloody diarrhoea - generalised - high PCV gastroenteritis - Dark red heamorrhage- distended - Vomiting - rare form in neonatal pups - >55% = HGE - Abdominal pain less than 2 weeks of age - small intestine: segmental, - Lethargy - necorsis of various organs - - death occurs by 10 days of transmural necroheamorrhagic Loss of appetite age enteritis - Dehydration - Fever - segmental lesion on small intestine - cardiac form (lymphocytic - Collapse - Dark pink, fibrosis - distended myocarditis) - pups infected early in life - small intestine: segmental when myocardial cells are fibrinonecrotising enteritis still replacing - viral mRNA + in situ - Intranuclear inclusion bodies in hybridisation signal is most nucleus of columnar epithelial cells abundant in dogs 21-56 - Blunted villi days, but has been observed - Heamorrhage in dogs up to 84 days - Depletion of lymphoid tissue of age - small intestine: diffuse, severe, - leukopenia/enteritis - common in pups 15 days + necrotising enteritis with villar older blunting + fusion, crypt hyperplasia, lymphoid depletion with lymphocytolysis + intracellular viral inclusions Disease What does it look like Lesions Clinical signs Pathogenesis/causes Diagnosis - diffuse atrophy of heart - Dark red petechial heamorrhage - Multifocal to coalescing - heart: multifocal to coalescing necroheamorrhagic myocarditis Infectious canine hepatitis - corneal oedema - leukopenia - virally induced endothelial - adenovirus 1 - affect - Gall bladder colistitis - Fever damage -> disseminated liver - Jaundice intravascular coagulation + - Adenovirus 2 - affects - enlarged liver - Depression heamorrhagic diathesis lungs - Diffuse hemorrhagic - exhaution of clotting factors - Loss of appetite - Intranuclear inclusion bodies (DIC) largely due to their - Vomiting - PCR accelerated consumption, as - Abdominal pain - Complete blood count - liver: diffuse hemorrhagic hepatitis the widespread endothelial - Coughing - Coagulation tests damage is a potent initiator - severe, acute, diffuse centrilobular - Bleeding - Ultrasound to see of the clotting cascade to midzonal bridging hepatic - some dogs that recover enlarged liver necrosis with mild lymphohistiocytic develop immune complex - Liver biopsy hepatitis + intranuclear inclusion glomerulonephritis, corneal bodies oedema + anterior uveitis due to type 3 hypersensitivity reaction