Kidney Diseases Overview
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Chronic Kidney Disease (CKD)

A progressive loss of kidney function over time.

End-Stage Renal Disease (ESRD)

Final stage of CKD requiring dialysis or transplant.

Most common cause of ESRD

Diabetes mellitus accounts for the majority of ESRD cases.

Characteristic finding of CKD

Persistent proteinuria indicates glomerular damage.

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Acute Kidney Injury (AKI)

Sudden loss of kidney function, often reversible.

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Common reversible cause of AKI

Obstructive uropathy from blockage leads to AKI.

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Indication of prerenal AKI

FeNa < 1% suggests low renal perfusion.

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IgA nephropathy

A glomerular disease presenting with 'cola-colored' urine.

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Hallmark of nephrotic syndrome

Proteinuria > 3.5 g/day indicates significant kidney damage.

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PKD1 mutation

Most severe genetic mutation causing autosomal dominant polycystic kidney disease.

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Post-infectious glomerulonephritis

Characterized by subepithelial 'hump-like' deposits.

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Goodpasture syndrome

Associated with anti-glomerular basement membrane antibodies.

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Most common cause of nephrotic syndrome in adults

Diabetic nephropathy due to high blood sugar.

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Minimal change disease

Show podocyte foot process effacement on EM.

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Diagnostic test for renal artery stenosis

Doppler ultrasound confirms renal artery narrowing.

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Most dangerous electrolyte abnormality in CKD

Hyperkalemia can cause life-threatening arrhythmias.

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Common complication of ADPKD

Kidney stones due to urinary stasis.

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Most common type of kidney stone

Calcium oxalate stones are the most frequent.

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First-line treatment for nephrotic syndrome

Corticosteroids are commonly used for minimal change disease.

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Best initial imaging for obstructive uropathy

Renal ultrasound is safe and effective.

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Electrolyte disturbance in renal tubular acidosis

Type 1 RTA is associated with hypokalemia.

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Acid-base disturbance in advanced CKD

Metabolic acidosis due to impaired acid excretion.

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Vesicoureteral reflux diagnosis

Voiding cystourethrogram (VCUG) detects reflux.

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Hallmark finding in membranous nephropathy

Spike and dome pattern on silver stain.

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Renal cell carcinoma

Most common type of kidney cancer in adults.

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Most tested nephrologic exam topic

Diabetic nephropathy is a critical subject in exams.

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Renal failure symptom

Uremia leads to complex symptoms including nausea.

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Dialysis initiation criteria

Volume overload unresponsive to diuretics indicates need.

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Complication of hemodialysis

Hypotension during treatment is common.

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Study Notes

Chronic Kidney Disease (CKD)

  • Most common cause of end-stage renal disease (ESRD) is diabetes mellitus.
  • Persistent proteinuria is a characteristic laboratory finding of CKD, indicating glomerular damage.

Acute Kidney Injury (AKI)

  • Obstructive uropathy is a common reversible cause of AKI.
  • A low fractional excretion of sodium (FeNa < 1%) is indicative of prerenal AKI.
  • Urine sediment with RBC casts is not indicative of prerenal AKI.

Glomerular Diseases

  • IgA nephropathy is associated with "cola-colored" urine.
  • Minimal change disease is associated with podocyte foot process effacement.

Polycystic Kidney Disease

  • PKD1 on chromosome 16 is the most likely genetic mutation in patients with multiple kidney cysts and flank pain/hematuria.
  • Cardiovascular disease is the most common cause of death in patients with ADPKD.

Nephrotic Syndrome

  • Minimal change disease is the most common cause of nephrotic syndrome in children.
  • Diabetic nephropathy is the most common cause of nephrotic syndrome in adults.

Renal Vascular Disease

  • Doppler ultrasound is the best diagnostic test to confirm renal artery stenosis.
  • Fibromuscular dysplasia is associated with a "string of beads" appearance on imaging studies.

Acute Tubular Necrosis

  • Muddy brown casts in the urine are characteristic of acute tubular necrosis (ATN).

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Description

Test your knowledge on various kidney diseases including Chronic Kidney Disease (CKD), Acute Kidney Injury (AKI), and Glomerular Diseases. This quiz covers common causes, laboratory findings, and genetic factors associated with these conditions, providing a comprehensive overview of kidney health.

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