Pharm MH

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Which mnemonic is commonly used to remember the clinical features of depression?

SIGECAPS (correct)

COLDSPA

APGAR

BLOOD

What does the Monoamine Hypothesis for depression propose?

Deficiency in Serotonin (5-HT), NE, and Dopamine (correct)

Excess of Serotonin (5-HT)

Balanced levels of neurotransmitters

Only Dopamine deficiency

What is the first line treatment for depression?

SSRI (correct)

Tricyclic Antidepressants

MAO Inhibitors

Bupropion

What is the mechanism of action for SSRIs?

Inhibit Serotonin reuptake at the presynaptic neuron. (A) Signup and view all the answers

Which of the following are major adverse effects of SSRIs? (Select all that apply)

Sexual Dysfunction (A), Weight Gain (B) Signup and view all the answers

SSRIs can cause what in patients with bipolar disorder?

Risk of Mania (A) Signup and view all the answers

SSRI durgs are?

Fluoxetin (A), Praoxetine (B), Escitalopram (C), Sertraline (D) Signup and view all the answers

Which of the following drugs are classified as SNRIs? (Select all that apply)

Velafaxine (A), Desvenlafaxine (C) Signup and view all the answers

Which of the following medications inhibit CYP2D6? (Select all that apply)

Fluoxetine (A), Paroxetine (B) Signup and view all the answers

What is a good option for antidepressant medication during pregnancy?

Sertraline (A) Signup and view all the answers

Which of the following are signs and symptoms of Serotonin Syndrome? (Select all that apply)

AMS, Incoordination, myoclonus. (A), Fever, muscle rigidity. (B), fever, excessive sweating (D) Signup and view all the answers

What depression medications may cause septal heart defects?

Paroxetine (A), Fluoxetine (B) Signup and view all the answers

Bupropion is indicated for treating depression and what other condition?

Low Energy (D) Signup and view all the answers

What is the mechanism of action of Bupropion?

Inhibits norepinephrine and dopamine reuptake (A) Signup and view all the answers

A patient with a history of seizures would like a depression medication. Which medication would increase the risk of seizures?

Bupropion (A) Signup and view all the answers

What is the mechanism of action of Tricyclic Antidepressants?

Inhibits Serotonin and Norepinephrine reuptake. (A) Signup and view all the answers

Which of the following drugs are TCAs?

Imipramine (A) Signup and view all the answers

A patient comes in with a complaint of sedation, orthostatic hypotension, dry mouth, and cardiac issues. What medication class should not be prescribed?

TCAs (A) Signup and view all the answers

What class of drug is Phenelzine?

Monoamine Oxidase Inhibitor (MAOI) (B) Signup and view all the answers

What is the mechanism of action of MAOIs?

Irreversibly inhibits monoamine oxidase, increasing serotonin, norepinephrine, and dopamine. (A) Signup and view all the answers

A hypertensive crisis can occur if a patient takes MAOIs along with?

Products containing Tyramine (A) Signup and view all the answers

Which of the following foods are rich in tyramine? (Select all that apply)

Aged cheese (A), Processed meats (C), Wine (D) Signup and view all the answers

Which of the following are first-line medications for Moderate to Severe Anxiety? (Select all that apply)

Venlafaxine (A), Duloxetine (B), Paroxetine (C), Escitalopram (D), Buspirone (@) Signup and view all the answers

What is the mechanism of action of buspirone?

Partial agonist at 5-HT1A receptor, some dopamine D2 activity (A) Signup and view all the answers

What is the key difference between Buspirone and Benzodiazepine?

Buspirone does not affect GABA receptor (A) Signup and view all the answers

What is the mechanism of action of benzodiazepines?

Enhances GABA-A receptor activity (B) Signup and view all the answers

Which of the following are key adverse effects of benzodiazepines? (Select all that apply)

Psychomotor slowing (B), Sedation (A) Signup and view all the answers

Capital of France (example flashcard)

Paris