Questions and Answers
What is the name of the process where acetyl CoA derived from fatty acid oxidation is converted into ketone bodies in the liver?
Ketogenesis
Which two water-soluble ketone bodies are transported in the blood to the heart for energy production?
Acetoacetate and 3-Hydroxybutyrate
What process occurs in the heart where ketone bodies are reconverted to acetyl CoA for oxidation by the TCA cycle?
Ketolysis
In cases of starvation and uncontrolled diabetes mellitus, what happens to the heart's use of ketone bodies for fuel?
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What is the primary purpose of utilizing ketone bodies as a fuel source in the heart?
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Study Notes
Ketone Bodies as a Source of Fuel
- In cases of starvation and uncontrolled Diabetes Mellitus (DM), the heart can use ketone bodies as a source of fuel.
- Ketone bodies are produced in the liver mitochondria through a process called ketogenesis, which converts acetyl CoA derived from fatty acid (FA) oxidation.
- There are two functional water-soluble ketone bodies: Acetoacetate and 3-hydroxybutyrate.
- These ketone bodies are transported in the blood to the heart.
- In the heart, ketone bodies are reconverted to acetyl CoA, which can then be oxidized by the TCA (Tricarboxylic Acid) cycle to produce energy.
- The process of utilizing ketone bodies as fuels is called ketolysis.
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