Ketone Bodies: Metabolism and Functions
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Questions and Answers

What is the main function of ketone bodies in the body?

  • Enhance muscle growth and repair
  • Serve as alternative fuel when glucose is scarce (correct)
  • Regulate hormone production in the liver
  • Act as structural components of cell membranes
  • Which of the following compounds are collectively known as ketone bodies?

  • Acetyl CoA, pyruvate, succinyl-CoA
  • Acetate, propionate, butyrate
  • Lactate, malate, citrate
  • Acetoacetate, β-hydroxybutyrate, acetone (correct)
  • During which state does the hepatic production of acetoacetate and β-hydroxybutyrate increase significantly?

  • Exercise state
  • Postprandial state
  • Sleeping state
  • Starvation state (correct)
  • What triggers the process of ketone body synthesis (ketogenesis) in the liver?

    <p>Excess acetyl CoA from β-oxidation</p> Signup and view all the answers

    In what conditions do the concentrations of acetoacetate and β-hydroxybutyrate remain low in the blood?

    <p>During the fed state</p> Signup and view all the answers

    Which statement about ketone bodies is true?

    <p>They are a main source of energy for the brain during prolonged starvation</p> Signup and view all the answers

    What is the role of ketone bodies in the body?

    <p>They can be used by extrahepatic tissues to meet energy needs</p> Signup and view all the answers

    Which enzyme is considered the rate-limiting step in ketone body synthesis?

    <p>HMG-CoA synthase</p> Signup and view all the answers

    How does glucagon hormone affect HMG-CoA synthase activity?

    <p>Activates HMG-CoA synthase</p> Signup and view all the answers

    What happens to HMG-CoA synthase activity when CoASH levels in the liver are high?

    <p>HMG-CoA synthase is inhibited</p> Signup and view all the answers

    How do ketone bodies contribute to sparing glucose during fasting?

    <p>Ketone bodies can be used as an alternative fuel source instead of glucose</p> Signup and view all the answers

    Which tissue can use ketone bodies to meet its energy needs?

    <p>Brain</p> Signup and view all the answers

    What triggers an increase in the production of ketone bodies during fasting?

    <p>Insulin deficiency</p> Signup and view all the answers

    In which tissues are ketone bodies utilized as a fuel during prolonged starvation?

    <p>Muscles, brain, and kidneys</p> Signup and view all the answers

    What happens when the rate of formation of ketone bodies exceeds their utilization?

    <p>Ketonemia and ketonuria occur</p> Signup and view all the answers

    Which enzyme is responsible for reactivating acetoacetate to form acetoacetyl CoA in nonhepatic tissues?

    <p>Thiophorase</p> Signup and view all the answers

    What is the main cause of ketosis in diabetic patients with uncontrolled blood glucose?

    <p>Insulin deficiency</p> Signup and view all the answers

    How does the lack of insulin contribute to increased ketone body synthesis?

    <p>It decreases glucose utilization</p> Signup and view all the answers

    What process is increased as a result of following a strict ketogenic diet?

    <p>Lipolysis</p> Signup and view all the answers

    Which of the following is a consequence of a significant reduction in blood sugar levels due to a ketogenic diet?

    <p>Hypoglycemia</p> Signup and view all the answers

    What is the primary metabolic role of ketone bodies in the body?

    <p>Fuel for the brain and muscles</p> Signup and view all the answers

    What happens if there is a progressive depletion of the alkali reserve in the blood due to the presence of certain acids?

    <p>Ketoacidosis</p> Signup and view all the answers

    Which condition is associated with uncontrolled diabetes and is characterized by high levels of ketone bodies in the blood?

    <p>Diabetic ketoacidosis (DKA)</p> Signup and view all the answers

    What is the major consequence of high fat and protein intake in ketogenic diets?

    <p>Ketoacidosis</p> Signup and view all the answers

    How do ketone bodies put the body into a state of ketosis?

    <p>By being used as the primary energy source</p> Signup and view all the answers

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