Podcast
Questions and Answers
A patient with a history of head trauma is admitted with symptoms of hyponatremia and decreased urine output. Lab results show low serum osmolality and high urine osmolality. Which condition is most likely causing these findings?
A patient with a history of head trauma is admitted with symptoms of hyponatremia and decreased urine output. Lab results show low serum osmolality and high urine osmolality. Which condition is most likely causing these findings?
- Primary hyperaldosteronism
- Syndrome of Inappropriate Antidiuretic Hormone (SIADH) (correct)
- Diabetes Insipidus (DI)
- Adrenal insufficiency
A patient with SIADH is being treated with fluid restriction and diuretics. Which assessment finding warrants immediate notification of the physician?
A patient with SIADH is being treated with fluid restriction and diuretics. Which assessment finding warrants immediate notification of the physician?
- Weight decrease of 0.5 kg in 24 hours.
- Serum sodium level of 130 mEq/L.
- Complaints of muscle twitching and confusion. (correct)
- Urine output of 800 mL in the past 24 hours.
Which of the following medications is least likely to be associated with causing SIADH?
Which of the following medications is least likely to be associated with causing SIADH?
- Phenothiazines
- Furosemide (correct)
- Thiazide diuretics
- Tricyclic antidepressants
A patient with SIADH secondary to small cell lung cancer is undergoing treatment. Which of the following nursing interventions is most important to include in the patient's plan of care?
A patient with SIADH secondary to small cell lung cancer is undergoing treatment. Which of the following nursing interventions is most important to include in the patient's plan of care?
Which of the following conditions is least likely to be a cause of SIADH?
Which of the following conditions is least likely to be a cause of SIADH?
Which of the following best describes the role of the hypothalamus within the endocrine system?
Which of the following best describes the role of the hypothalamus within the endocrine system?
A patient is diagnosed with a pituitary tumor that selectively impairs the secretion of adrenocorticotropic hormone (ACTH). Which of the following hormonal imbalances would most likely be observed in this patient?
A patient is diagnosed with a pituitary tumor that selectively impairs the secretion of adrenocorticotropic hormone (ACTH). Which of the following hormonal imbalances would most likely be observed in this patient?
A patient with hypopituitarism is prescribed hormone replacement therapy. What key education should the nurse provide to the patient regarding their medication regimen?
A patient with hypopituitarism is prescribed hormone replacement therapy. What key education should the nurse provide to the patient regarding their medication regimen?
Which of the following hormones directly promotes protein synthesis and fat metabolism while decreasing carbohydrate metabolism?
Which of the following hormones directly promotes protein synthesis and fat metabolism while decreasing carbohydrate metabolism?
A patient presents with symptoms of fatigue, muscle weakness, and increased sensitivity to cold. Initial blood tests reveal low levels of thyroid hormones. Which pituitary hormone is most likely affected, leading to these symptoms?
A patient presents with symptoms of fatigue, muscle weakness, and increased sensitivity to cold. Initial blood tests reveal low levels of thyroid hormones. Which pituitary hormone is most likely affected, leading to these symptoms?
Following a traumatic brain injury, a patient develops polyuria and polydipsia. Which hormone deficiency should be suspected?
Following a traumatic brain injury, a patient develops polyuria and polydipsia. Which hormone deficiency should be suspected?
A patient is diagnosed with panhypopituitarism. Which of the following is the most comprehensive approach to managing this condition?
A patient is diagnosed with panhypopituitarism. Which of the following is the most comprehensive approach to managing this condition?
A child is exhibiting signs of significantly stunted growth compared to their peers. After evaluation, a deficiency in a specific anterior pituitary hormone is suspected. Which hormone is most likely deficient?
A child is exhibiting signs of significantly stunted growth compared to their peers. After evaluation, a deficiency in a specific anterior pituitary hormone is suspected. Which hormone is most likely deficient?
A patient with Addison's disease is scheduled for elective surgery. Which adjustment to their medication regimen is most important to prevent an Addisonian crisis?
A patient with Addison's disease is scheduled for elective surgery. Which adjustment to their medication regimen is most important to prevent an Addisonian crisis?
A patient with secondary adrenal insufficiency is being discharged. What is the most important point to emphasize in their discharge teaching regarding medication management?
A patient with secondary adrenal insufficiency is being discharged. What is the most important point to emphasize in their discharge teaching regarding medication management?
A patient with Addison's disease reports experiencing increased fatigue, muscle weakness, and dizziness when standing. Which of the following electrolyte imbalances is most likely contributing to these symptoms?
A patient with Addison's disease reports experiencing increased fatigue, muscle weakness, and dizziness when standing. Which of the following electrolyte imbalances is most likely contributing to these symptoms?
Which of the following assessment parameters is most important for the nurse to monitor in a patient receiving mineralocorticoid replacement for Addison's disease?
Which of the following assessment parameters is most important for the nurse to monitor in a patient receiving mineralocorticoid replacement for Addison's disease?
A patient with Addison's disease is admitted to the emergency department with suspected adrenal crisis. After initiating intravenous access, which intervention should the nurse perform first?
A patient with Addison's disease is admitted to the emergency department with suspected adrenal crisis. After initiating intravenous access, which intervention should the nurse perform first?
A nurse is providing dietary education to a patient with Addison's disease. Which dietary modification is most important for the nurse to recommend?
A nurse is providing dietary education to a patient with Addison's disease. Which dietary modification is most important for the nurse to recommend?
What is the primary difference in the underlying cause between primary and secondary adrenal insufficiency (Addison's disease)?
What is the primary difference in the underlying cause between primary and secondary adrenal insufficiency (Addison's disease)?
Which of the following signs and symptoms would indicate that a patient with Addison's disease may be experiencing an Addisonian crisis?
Which of the following signs and symptoms would indicate that a patient with Addison's disease may be experiencing an Addisonian crisis?
A patient presents with fatigue, weight gain, and cold intolerance. Lab results show elevated TSH and low T3 and T4. What is the MOST likely diagnosis?
A patient presents with fatigue, weight gain, and cold intolerance. Lab results show elevated TSH and low T3 and T4. What is the MOST likely diagnosis?
Which cardiovascular manifestation is associated with long-standing hypothyroidism, posing a significant health risk for affected individuals?
Which cardiovascular manifestation is associated with long-standing hypothyroidism, posing a significant health risk for affected individuals?
A patient undergoing treatment for hyperthyroidism develops a sudden, severe exacerbation of symptoms including fever, tachycardia and altered mental status. Which complication is MOST likely?
A patient undergoing treatment for hyperthyroidism develops a sudden, severe exacerbation of symptoms including fever, tachycardia and altered mental status. Which complication is MOST likely?
Following a thyroidectomy, a patient reports tingling around the mouth and fingertips, along with muscle spasms. Which electrolyte imbalance is the MOST likely cause?
Following a thyroidectomy, a patient reports tingling around the mouth and fingertips, along with muscle spasms. Which electrolyte imbalance is the MOST likely cause?
What physiological response occurs when serum calcium levels are low, mediated by parathyroid hormone (PTH)?
What physiological response occurs when serum calcium levels are low, mediated by parathyroid hormone (PTH)?
A patient with chronic kidney disease develops secondary hyperparathyroidism. What is the underlying mechanism driving this endocrine disorder?
A patient with chronic kidney disease develops secondary hyperparathyroidism. What is the underlying mechanism driving this endocrine disorder?
What is the primary mechanism by which aldosterone, a mineralocorticoid, regulates fluid and electrolyte balance?
What is the primary mechanism by which aldosterone, a mineralocorticoid, regulates fluid and electrolyte balance?
A patient with Cushing's syndrome is at increased risk for infections. Which mechanism BEST explains this increased susceptibility?
A patient with Cushing's syndrome is at increased risk for infections. Which mechanism BEST explains this increased susceptibility?
A patient presents with muscle weakness, fatigue, and frequent urination. Lab results reveal hypokalemia, metabolic alkalosis, and hypertension. Which condition is MOST likely?
A patient presents with muscle weakness, fatigue, and frequent urination. Lab results reveal hypokalemia, metabolic alkalosis, and hypertension. Which condition is MOST likely?
A patient is diagnosed with Cushing's syndrome due to a pituitary tumor. How does this etiology differ from Cushing’s syndrome caused by long-term steroid use?
A patient is diagnosed with Cushing's syndrome due to a pituitary tumor. How does this etiology differ from Cushing’s syndrome caused by long-term steroid use?
A patient with a history of Hashimoto's thyroiditis is started on levothyroxine. After several weeks, the patient reports persistent fatigue and constipation despite taking the medication as prescribed. What is the MOST appropriate next step?
A patient with a history of Hashimoto's thyroiditis is started on levothyroxine. After several weeks, the patient reports persistent fatigue and constipation despite taking the medication as prescribed. What is the MOST appropriate next step?
A patient who underwent a thyroidectomy is being discharged. Which of the following instructions is MOST critical to include in their discharge teaching?
A patient who underwent a thyroidectomy is being discharged. Which of the following instructions is MOST critical to include in their discharge teaching?
A patient with hyperparathyroidism develops a kidney stone. What is the underlying mechanism linking hyperparathyroidism to kidney stone formation?
A patient with hyperparathyroidism develops a kidney stone. What is the underlying mechanism linking hyperparathyroidism to kidney stone formation?
A patient with Cushing's syndrome presents with a new onset of hyperglycemia. What is the primary mechanism by which excess cortisol contributes to this metabolic complication?
A patient with Cushing's syndrome presents with a new onset of hyperglycemia. What is the primary mechanism by which excess cortisol contributes to this metabolic complication?
A patient on long-term corticosteroid therapy is being evaluated for osteoporosis. What is the MOST important intervention to prevent or manage corticosteroid-induced bone loss?
A patient on long-term corticosteroid therapy is being evaluated for osteoporosis. What is the MOST important intervention to prevent or manage corticosteroid-induced bone loss?
A patient presents with frequent thirst and excessive urine output following a head trauma. Initial lab results show high serum osmolality and low urine osmolarity. Which of the following conditions is the most likely cause of these manifestations?
A patient presents with frequent thirst and excessive urine output following a head trauma. Initial lab results show high serum osmolality and low urine osmolarity. Which of the following conditions is the most likely cause of these manifestations?
A patient is diagnosed with a pituitary tumor that is NOT secreting any hormones. Which of the following is the MOST likely endocrine consequence of this type of tumor?
A patient is diagnosed with a pituitary tumor that is NOT secreting any hormones. Which of the following is the MOST likely endocrine consequence of this type of tumor?
A patient who recently underwent neurosurgery develops Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Which of the following sets of electrolyte and fluid balance findings would you MOST likely see in this patient?
A patient who recently underwent neurosurgery develops Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Which of the following sets of electrolyte and fluid balance findings would you MOST likely see in this patient?
Why does a medical ID need to be worn at all times for a patient with Diabetes Insipidus?
Why does a medical ID need to be worn at all times for a patient with Diabetes Insipidus?
A patient presents with progressive enlargement of the hands and feet, along with increased sweating and joint pain. The physician suspects a pituitary adenoma. Which hormone is MOST likely being over secreted in this patient?
A patient presents with progressive enlargement of the hands and feet, along with increased sweating and joint pain. The physician suspects a pituitary adenoma. Which hormone is MOST likely being over secreted in this patient?
A patient is diagnosed with Diabetes Insipidus (DI) following a head injury. Besides desmopressin, which instruction is MOST important for the nurse to include in the patient's discharge teaching plan?
A patient is diagnosed with Diabetes Insipidus (DI) following a head injury. Besides desmopressin, which instruction is MOST important for the nurse to include in the patient's discharge teaching plan?
What is the primary difference between Diabetes Insipidus caused by a brain tumor versus SIADH caused by malignant cells?
What is the primary difference between Diabetes Insipidus caused by a brain tumor versus SIADH caused by malignant cells?
A patient with a known pituitary tumor develops hypopituitarism. What are the likely underlying mechanisms of this condition related to the tumor?
A patient with a known pituitary tumor develops hypopituitarism. What are the likely underlying mechanisms of this condition related to the tumor?
A patient with a head injury is producing excessive amounts of antidiuretic hormone (ADH). Which clinical manifestation would the nurse expect to observe?
A patient with a head injury is producing excessive amounts of antidiuretic hormone (ADH). Which clinical manifestation would the nurse expect to observe?
A patient is diagnosed with Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH) related to lung cancer. Which intervention is the priority for the nurse?
A patient is diagnosed with Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH) related to lung cancer. Which intervention is the priority for the nurse?
A patient is being treated for SIADH with hypertonic saline (3%). Which assessment finding requires the most immediate intervention?
A patient is being treated for SIADH with hypertonic saline (3%). Which assessment finding requires the most immediate intervention?
A patient is scheduled for a transsphenoidal hypophysectomy. Which preoperative instruction should the nurse emphasize to the patient?
A patient is scheduled for a transsphenoidal hypophysectomy. Which preoperative instruction should the nurse emphasize to the patient?
Following a transsphenoidal hypophysectomy, a patient reports a persistent headache and the nurse notes clear nasal drainage. What is the nurse's priority action?
Following a transsphenoidal hypophysectomy, a patient reports a persistent headache and the nurse notes clear nasal drainage. What is the nurse's priority action?
A patient is being discharged after a transsphenoidal hypophysectomy. Which long-term education point is most important for the nurse to emphasize?
A patient is being discharged after a transsphenoidal hypophysectomy. Which long-term education point is most important for the nurse to emphasize?
The hypothalamus releases thyrotropin-releasing hormone (TRH), which stimulates the pituitary gland to release thyroid-stimulating hormone (TSH). What is the primary role of TSH?
The hypothalamus releases thyrotropin-releasing hormone (TRH), which stimulates the pituitary gland to release thyroid-stimulating hormone (TSH). What is the primary role of TSH?
A patient has a tumor that is causing excessive secretion of calcitonin. Which laboratory finding would the nurse expect to see?
A patient has a tumor that is causing excessive secretion of calcitonin. Which laboratory finding would the nurse expect to see?
A patient with a known pituitary tumor is admitted for treatment of SIADH. Which medication from the patient's home medication list should the nurse question?
A patient with a known pituitary tumor is admitted for treatment of SIADH. Which medication from the patient's home medication list should the nurse question?
Following a transsphenoidal hypophysectomy, a patient is at risk for developing diabetes insipidus (DI). Which assessment finding would indicate the development of DI?
Following a transsphenoidal hypophysectomy, a patient is at risk for developing diabetes insipidus (DI). Which assessment finding would indicate the development of DI?
Flashcards
Hormones
Hormones
Chemical transmitters that regulate body functions by acting on target sites.
Hypothalamus
Hypothalamus
Controls release of pituitary hormones.
Growth Hormone (GH)
Growth Hormone (GH)
Stimulates growth of bone and muscle; promotes protein synthesis and fat metabolism.
Adrenocorticotropic Hormone (ACTH)
Adrenocorticotropic Hormone (ACTH)
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Thyroid-Stimulating Hormone (TSH)
Thyroid-Stimulating Hormone (TSH)
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Antidiuretic Hormone (ADH)
Antidiuretic Hormone (ADH)
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Hypopituitarism
Hypopituitarism
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Panhypopituitarism
Panhypopituitarism
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Pituitary Tumors
Pituitary Tumors
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Giantism
Giantism
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Acromegaly
Acromegaly
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Diabetes Insipidus (DI)
Diabetes Insipidus (DI)
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SIADH (Syndrome of Inappropriate Antidiuretic Hormone)
SIADH (Syndrome of Inappropriate Antidiuretic Hormone)
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SIADH
SIADH
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SIADH Clinical Manifestations
SIADH Clinical Manifestations
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SIADH Collaborative Care
SIADH Collaborative Care
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Causes of DI & SIADH
Causes of DI & SIADH
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Primary Addison's Disease
Primary Addison's Disease
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Secondary Addison's Disease
Secondary Addison's Disease
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Hormone Levels in Addison's
Hormone Levels in Addison's
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Addison's Manifestations
Addison's Manifestations
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Bronze Skin in Addison's
Bronze Skin in Addison's
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Addisonian Crisis Signs
Addisonian Crisis Signs
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Addison's Collaborative Care
Addison's Collaborative Care
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Addisonian Crisis Causes
Addisonian Crisis Causes
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Hypophysectomy
Hypophysectomy
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Indications for Hypophysectomy
Indications for Hypophysectomy
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Approaches to Hypophysectomy
Approaches to Hypophysectomy
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Post-op Care: Transsphenoidal Hypophysectomy
Post-op Care: Transsphenoidal Hypophysectomy
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CSF Leak Indication
CSF Leak Indication
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Long-Term Management After Hypophysectomy
Long-Term Management After Hypophysectomy
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Hypothalamus Hormone (Thyroid)
Hypothalamus Hormone (Thyroid)
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TSH Function
TSH Function
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Thyroid Hormones Function
Thyroid Hormones Function
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Calcitonin Action
Calcitonin Action
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Primary Hypothyroidism
Primary Hypothyroidism
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Secondary Hypothyroidism
Secondary Hypothyroidism
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Hashimoto's Thyroiditis
Hashimoto's Thyroiditis
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Myxedema Coma
Myxedema Coma
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Hyperthyroidism Labs
Hyperthyroidism Labs
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Grave's Disease
Grave's Disease
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Thyroid Storm
Thyroid Storm
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Exophthalmos
Exophthalmos
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Goiter
Goiter
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Thyroidectomy
Thyroidectomy
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Hypocalcemia
Hypocalcemia
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Parathyroid Hormone (PTH)
Parathyroid Hormone (PTH)
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Hypoparathyroidism
Hypoparathyroidism
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Hyperparathyroidism
Hyperparathyroidism
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Cushing's Syndrome/Disease
Cushing's Syndrome/Disease
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Study Notes
Module 2: Non-Diabetic Endocrine Disorders
- Focuses on endocrine disorders other than Diabetes mellitus
- The Endocrine system has organs include the hypothalamus, pineal gland, Pituitary (hypophysis), Thyroid, Parathyroid (posterior), Thymus, Adrenals, Islets of Langerhans (in pancreas), Testes and Ovaries.
Endocrine System Overview
- Hormones are chemical messengers that regulate and integrate body functions
- Hormones act on local or distant target sites.
- They work with the nervous system to finely control organ function
Hypothalamus and Pituitary Glands
- The hypothalamus releases and inhibits hormones that control the pituitary hormones
- Corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone (TRH), and growth hormone-releasing hormone (GHRH) are specific Hypothalamus hormones.
- The anterior Pituitary gland produces Growth hormone (GH); that stimulates bone and muscle growth
- Adrenocorticotropic hormone (ACTH) is created by the anterior Pituitary, which stimulates synthesis and secretion of adrenal cortical hormones
- Thyroid-stimulating hormone (TSH) is made by the Ant Pituitary, and stimulates synthesis and secretion of thyroid hormones
- The posterior pituitary produces antidiuretic hormone (ADH)
- Antidiuretic hormone (ADH) is also called Vasopressin
Hypopituitarianism/Pituitary Insufficiency
- Hypopituitarism involves the hyposecretion of 1+ pituitary hormones
- Etiologies include tumors, infarction, trauma, and radiation
- The hormones are impacted based on impact location in the Pituitary
- Losing all pituitary hormones, is rare, is called Panhypopituitarianism
- Collaborative care includes identifying the cause and treating it
- Collaborative care includes replacing deficient hormones
- Collaborate with patients, and educate them about hormone replacement and signs and symptoms of hormone excess or deficiencies
Pituitary Tumors
- Pituitary tumors are almost all begin
- Tumors can cause oversecretion of growth hormones, resulting in Gigantism or Acromegaly
- Tumors can cause oversecretion of ACTH, resulting in Cushing's
- Some tumors can cause undersecretion of all pituitary hormones which happens in 90% of pituitary tumors
- Tumors cause undersecretion because they don't produce hormones, but they destroy the pituitary's ability to release other hormons
- The undersecretion leads to hypopituitarianisn
Posterior Pituitary: Antidiuretic Hormone Disorders (ADH/Vasopressin)
- Diabetes Insipidus (DI) results from insufficient ADH
- Syndrom of Inappropriate Antidiuretic Hormone (SIADH) occurs because of excess ADH
Diabetes Insipidus (DI)
- Insufficient ADH
- Causes include head trauma, neurosurgery, radiation of the pituitary or brain, CNS infections, or tumor
- Clinical manifestations are thirst, profound urine output (over 250 mL per hours), and dilute urine
- Hypovolemia, high serum osmolality and serum sodium, and Low urine osmolarity are also clinical manifestations
- Interventions are treat the cause and replace ADH which is managed with Desmopressin (a synthetic vasopressin), fluid replacement, I and O monitoring, ensure pt. education, and take preventative and emergency measures
- Patients should wear medical ID at all times in case of emergancy
SIADH
- Excess ADH
- Causes include head truama, neurosurgery, radiation, infection, malignant cells, lung disorders, and medications
- Clinical manifestations are neurological symptoms of Hypervolemia
- Decreased urine output, concentrated urine, hypervolemia and low serum osmolality, low serum sodium and high urine osmolality
- Interventions: treat the cause, slow the sodium replacement, loop diuretics, fluid restriction, I and O measures, neurologic monitoring, seizure precautions, skin care with edema, noting that ongoing cases are rare
Hypophysectomy
- Definition: Partial or complete removal of the pituitary gland
- Indications: Pituitary tumors, diabetic retinopathy, metastatic breast and prostate cancer
- Approaches include craniotomy and transphenoidal (most common)
- Post op care for trandphenoidal hypohysectomy, monitor for target organ deficiencies, HOB elevated to 30, treat headaches, avoid tooth brushing, don't sneeze Observe for CSF leak from the nose (clear drainage, drainage tests positive for glucose), elevate HOB and call MD
- Patient education: hormone replacement, and a medical id bracelet.
Thyroid Disorders
- Disorders of the thyroid
Thyroid Hormones
- The hypothalamus produces thyrotropin-releasing hormone (TRH), stimulating the pituitary to release thyroid stimulating hormone (TSH)
- TSH stimulates the thyroid to produce hormones T3/4
- T3 has four iodine atoms in each molecule, and T4 contains three iodine atoms in each molecule
- Calcitonin is also produced by the thyroid
- Calcitonin is released in response to high serum calcium
- Calcitonin reduces plasma calcium by increasing its deposition in bone
- Think of the thyroid as metabolism
Hypothyroidism
- Inadequate TSH release (Pituitary problem), results in failure for thyroid to be stimulated , has low TSH and T3/4, secondary hypothyroidism
- Thyroid problem, TSH released from pituitary, thyroid does not respond, so the pituitary increases TSH. Has a high TSH and low T3/4, is primary hypothyroidism
Hypothyroidism Manifestations
- Pathology: insufficient production of thyroid, slowing of metabolis
- Hashimotos thyroiditis, post treatment for graves disease are common forms.
- General: Cold intolerant, lethargic weak, weight gain, forgetful and depression CNS: muscle exhaustion, cognitive slowing and short term memory loss
- HEENT: dull expression, thin hair and dry, coarse scaly skin, periorbital edema, a goiter can be present
Hypothyroidism: CV Manifestations
- Bradycardia
- Elevated cholesterol
- Atherosclerosis
- Risks of acute coronary syndrome
- Left Ventricular Dysfunction
- GI: Decreased bowel sounds, constipation/impaction, fluid retention and anorexia
Hypothyroidism: Reproductive/Labs/Management
- Reproductive: in females, Heavy/prolonged periods, and in males, impotence
- Labs: low T3 & T4, high TSH in Primary
- Low T3 & T4, Low TSH in secondary
- Management: hormone replacement, low calorie foods
- Myxedema/myxedema coma can occur; also at risk for acute coronary syndrome
Hyperthyroidism
- Low TSH and high T3/4 causes overproduction from the thyroid suppressing the production of TSH
Hyperthyroidism-Manifestations/Labs/Management
- Pathology: overproduction of hormones
- Common forms, Graves
- General: heat intolerant, nervous, hyperactive, weight loss, and insomnia
- Increased DTRS
- HEENT: Bulging eyes, fine soft hair, sweating, and eyelid lag and stare
- CV: Tachycardia, bounding pulse, a-fib
- Labs: T3/4 increased, TSH decreased
- Management: antithyroid drugs, radioactive iodine and thyroidectomy
Exophthalmos
- Bulging eyes
Thyroid Tumors
- If the thyroid is enlarged, it becomes a goiter, and can enlarge due to iodine or a cancerous process.
- Nodular goiter is the most common benign goiter
Thyroidectomy
- Definition is removal of the thyroid, partial or total
- Done for patients who can not take antithyroid medication, large goiter or cancerous modules
- Postop focus on frequent calcium levels and montoring
- Watch for airway obstruction
- Watch for s/s of hyper/hypocalcemia
Parathyroid Disorders
- Superior and inferior parathyroids
Parathyroid Hormone
- Essential to calcium and phosphorous regulation
- Low Calcium = PTH Release
- Stimulates intestines vitamin D, and Bones demineralize
- High Calcium = No PTH Release
Parathyorid Physiology
- Low serum calcium, and enhanced vitmain D stimulates PTH which releases and absorbs vit d in the kidneys Normal serum calcium levels are needed
Parathyroid Disorders
- Hypo: there is low levels of PTH and symptoms of hypercalcemia
Adrenal Disorders
Adrenal Cortex Hormones
- Corticosteroids for stres adaptation, released in response to ACTH
- Cortisol to influence glucose metabilosm, Mobilize fat stores, Long term negative effects
- Mineralocorticosteroids, aldosterone, sodium adn potassium
- Androgens-sech hormones
Cushing's
- Syndrome: adrenal gland tumors, prolonged corticosteroid use
- Redistribution of fat to the abdomen, insulin resistance, hirsutism, wound healing is poor because of normal response to infection
- Truncal obseity, thin legs, muscle weakness and hyperglycemia
- Labs: hyerglycemia, hypokalemis, leukocytosis
- Treatment: adrenalectomies and potassium replacements steroids to maintain balance
Addison's
- Adranalectomy, illness stress, abrubt steroid cessation.
- Primary: adrenals not functioning;
- low cortisol and esterogen
- anorexia, nausea, weakness
- Labs: decrease cortisol and increase potassium
- Treat: Replace glucorticods and steriods, watch electrolytes
- Addisonian and Adrenal Crisis: insufficnet levels of cortisol-hypotension, severe pain, confusion. Treat shock, manage fever and stabalize mental states.
- With Steriod therapy, reduce cortisol levels to avoid crisis, and the patient is more susceptible to stress.
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