ANS Week 3: Non-Diabetic Endocrine Disorders
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A patient with a history of head trauma is admitted with symptoms of hyponatremia and decreased urine output. Lab results show low serum osmolality and high urine osmolality. Which condition is most likely causing these findings?

  • Primary hyperaldosteronism
  • Syndrome of Inappropriate Antidiuretic Hormone (SIADH) (correct)
  • Diabetes Insipidus (DI)
  • Adrenal insufficiency

A patient with SIADH is being treated with fluid restriction and diuretics. Which assessment finding warrants immediate notification of the physician?

  • Weight decrease of 0.5 kg in 24 hours.
  • Serum sodium level of 130 mEq/L.
  • Complaints of muscle twitching and confusion. (correct)
  • Urine output of 800 mL in the past 24 hours.

Which of the following medications is least likely to be associated with causing SIADH?

  • Phenothiazines
  • Furosemide (correct)
  • Thiazide diuretics
  • Tricyclic antidepressants

A patient with SIADH secondary to small cell lung cancer is undergoing treatment. Which of the following nursing interventions is most important to include in the patient's plan of care?

<p>Monitoring intake and output and daily weights. (B)</p> Signup and view all the answers

Which of the following conditions is least likely to be a cause of SIADH?

<p>Dehydration (C)</p> Signup and view all the answers

Which of the following best describes the role of the hypothalamus within the endocrine system?

<p>Controls the release of hormones from the pituitary gland through releasing and inhibiting hormones. (A)</p> Signup and view all the answers

A patient is diagnosed with a pituitary tumor that selectively impairs the secretion of adrenocorticotropic hormone (ACTH). Which of the following hormonal imbalances would most likely be observed in this patient?

<p>Decreased levels of adrenal cortical hormones. (D)</p> Signup and view all the answers

A patient with hypopituitarism is prescribed hormone replacement therapy. What key education should the nurse provide to the patient regarding their medication regimen?

<p>The importance of adhering to the medication schedule and monitoring for signs and symptoms of both hormone deficiencies and excesses. (A)</p> Signup and view all the answers

Which of the following hormones directly promotes protein synthesis and fat metabolism while decreasing carbohydrate metabolism?

<p>Growth hormone (GH) (C)</p> Signup and view all the answers

A patient presents with symptoms of fatigue, muscle weakness, and increased sensitivity to cold. Initial blood tests reveal low levels of thyroid hormones. Which pituitary hormone is most likely affected, leading to these symptoms?

<p>Thyroid-stimulating hormone (TSH) (B)</p> Signup and view all the answers

Following a traumatic brain injury, a patient develops polyuria and polydipsia. Which hormone deficiency should be suspected?

<p>Antidiuretic hormone (ADH) (B)</p> Signup and view all the answers

A patient is diagnosed with panhypopituitarism. Which of the following is the most comprehensive approach to managing this condition?

<p>Replacing all deficient hormones and treating the underlying cause. (B)</p> Signup and view all the answers

A child is exhibiting signs of significantly stunted growth compared to their peers. After evaluation, a deficiency in a specific anterior pituitary hormone is suspected. Which hormone is most likely deficient?

<p>Growth Hormone (B)</p> Signup and view all the answers

A patient with Addison's disease is scheduled for elective surgery. Which adjustment to their medication regimen is most important to prevent an Addisonian crisis?

<p>Increasing the corticosteroid dose before, during, and after the surgery. (D)</p> Signup and view all the answers

A patient with secondary adrenal insufficiency is being discharged. What is the most important point to emphasize in their discharge teaching regarding medication management?

<p>The necessity of lifelong glucocorticoid replacement therapy and never abruptly stopping the medication. (D)</p> Signup and view all the answers

A patient with Addison's disease reports experiencing increased fatigue, muscle weakness, and dizziness when standing. Which of the following electrolyte imbalances is most likely contributing to these symptoms?

<p>Hyponatremia (D)</p> Signup and view all the answers

Which of the following assessment parameters is most important for the nurse to monitor in a patient receiving mineralocorticoid replacement for Addison's disease?

<p>Potassium levels and blood pressure (B)</p> Signup and view all the answers

A patient with Addison's disease is admitted to the emergency department with suspected adrenal crisis. After initiating intravenous access, which intervention should the nurse perform first?

<p>Administering intravenous hydrocortisone. (D)</p> Signup and view all the answers

A nurse is providing dietary education to a patient with Addison's disease. Which dietary modification is most important for the nurse to recommend?

<p>Consume a high-sodium diet and ensure adequate fluid intake. (C)</p> Signup and view all the answers

What is the primary difference in the underlying cause between primary and secondary adrenal insufficiency (Addison's disease)?

<p>Primary adrenal insufficiency involves destruction of the adrenal glands, whereas secondary involves pituitary or hypothalamic dysfunction. (D)</p> Signup and view all the answers

Which of the following signs and symptoms would indicate that a patient with Addison's disease may be experiencing an Addisonian crisis?

<p>Hypotension, hyperkalemia, and severe abdominal pain. (C)</p> Signup and view all the answers

A patient presents with fatigue, weight gain, and cold intolerance. Lab results show elevated TSH and low T3 and T4. What is the MOST likely diagnosis?

<p>Primary hypothyroidism due to thyroid gland failure (A)</p> Signup and view all the answers

Which cardiovascular manifestation is associated with long-standing hypothyroidism, posing a significant health risk for affected individuals?

<p>Acute coronary syndrome (A)</p> Signup and view all the answers

A patient undergoing treatment for hyperthyroidism develops a sudden, severe exacerbation of symptoms including fever, tachycardia and altered mental status. Which complication is MOST likely?

<p>Thyroid storm (B)</p> Signup and view all the answers

Following a thyroidectomy, a patient reports tingling around the mouth and fingertips, along with muscle spasms. Which electrolyte imbalance is the MOST likely cause?

<p>Hypocalcemia (B)</p> Signup and view all the answers

What physiological response occurs when serum calcium levels are low, mediated by parathyroid hormone (PTH)?

<p>Increased calcium release from bones and decreased phosphorus reabsorption by the kidneys. (D)</p> Signup and view all the answers

A patient with chronic kidney disease develops secondary hyperparathyroidism. What is the underlying mechanism driving this endocrine disorder?

<p>Decreased renal excretion of phosphorus leading to hyperphosphatemia. (A)</p> Signup and view all the answers

What is the primary mechanism by which aldosterone, a mineralocorticoid, regulates fluid and electrolyte balance?

<p>Stimulating sodium reabsorption and water retention while promoting potassium excretion in the renal tubules. (A)</p> Signup and view all the answers

A patient with Cushing's syndrome is at increased risk for infections. Which mechanism BEST explains this increased susceptibility?

<p>Suppressed inflammatory response and inhibition of antibody production due to elevated cortisol levels. (C)</p> Signup and view all the answers

A patient presents with muscle weakness, fatigue, and frequent urination. Lab results reveal hypokalemia, metabolic alkalosis, and hypertension. Which condition is MOST likely?

<p>Primary hyperaldosteronism (B)</p> Signup and view all the answers

A patient is diagnosed with Cushing's syndrome due to a pituitary tumor. How does this etiology differ from Cushing’s syndrome caused by long-term steroid use?

<p>Cushing's disease specifically refers to excess ACTH secretion from a pituitary adenoma; Cushing's syndrome encompasses all other causes of excess cortisol, including steroid use. (B)</p> Signup and view all the answers

A patient with a history of Hashimoto's thyroiditis is started on levothyroxine. After several weeks, the patient reports persistent fatigue and constipation despite taking the medication as prescribed. What is the MOST appropriate next step?

<p>Evaluate the patient for other potential causes of fatigue and constipation, such as iron deficiency or depression, while checking thyroid function tests. (B)</p> Signup and view all the answers

A patient who underwent a thyroidectomy is being discharged. Which of the following instructions is MOST critical to include in their discharge teaching?

<p>Monitor for signs and symptoms of both hyperthyroidism and hypothyroidism. (C)</p> Signup and view all the answers

A patient with hyperparathyroidism develops a kidney stone. What is the underlying mechanism linking hyperparathyroidism to kidney stone formation?

<p>Elevated serum calcium levels causing increased calcium excretion in the urine. (A)</p> Signup and view all the answers

A patient with Cushing's syndrome presents with a new onset of hyperglycemia. What is the primary mechanism by which excess cortisol contributes to this metabolic complication?

<p>Reduced insulin secretion and increased gluconeogenesis. (A)</p> Signup and view all the answers

A patient on long-term corticosteroid therapy is being evaluated for osteoporosis. What is the MOST important intervention to prevent or manage corticosteroid-induced bone loss?

<p>Weight-bearing exercise, calcium and vitamin D supplementation, and consideration of bone-sparing medications. (D)</p> Signup and view all the answers

A patient presents with frequent thirst and excessive urine output following a head trauma. Initial lab results show high serum osmolality and low urine osmolarity. Which of the following conditions is the most likely cause of these manifestations?

<p>Diabetes Insipidus (DI) (B)</p> Signup and view all the answers

A patient is diagnosed with a pituitary tumor that is NOT secreting any hormones. Which of the following is the MOST likely endocrine consequence of this type of tumor?

<p>Hypopituitarism due to destruction of pituitary tissue. (B)</p> Signup and view all the answers

A patient who recently underwent neurosurgery develops Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Which of the following sets of electrolyte and fluid balance findings would you MOST likely see in this patient?

<p>Low serum sodium, high urine osmolality, hypervolemia (A)</p> Signup and view all the answers

Why does a medical ID need to be worn at all times for a patient with Diabetes Insipidus?

<p>To inform healthcare providers about the need for lifelong vasopressin replacement in emergency situations. (C)</p> Signup and view all the answers

A patient presents with progressive enlargement of the hands and feet, along with increased sweating and joint pain. The physician suspects a pituitary adenoma. Which hormone is MOST likely being over secreted in this patient?

<p>Growth Hormone (GH) (A)</p> Signup and view all the answers

A patient is diagnosed with Diabetes Insipidus (DI) following a head injury. Besides desmopressin, which instruction is MOST important for the nurse to include in the patient's discharge teaching plan?

<p>Wear a medical identification bracelet at all times. (B)</p> Signup and view all the answers

What is the primary difference between Diabetes Insipidus caused by a brain tumor versus SIADH caused by malignant cells?

<p>DI is caused by insufficient ADH leading to excessive thirst and urination, while SIADH is characterized by an excess of ADH causing water retention. (D)</p> Signup and view all the answers

A patient with a known pituitary tumor develops hypopituitarism. What are the likely underlying mechanisms of this condition related to the tumor?

<p>The tumor physically compresses and destroys normal pituitary tissue, impairing its ability to produce and release hormones. (D)</p> Signup and view all the answers

A patient with a head injury is producing excessive amounts of antidiuretic hormone (ADH). Which clinical manifestation would the nurse expect to observe?

<p>Low serum sodium levels. (C)</p> Signup and view all the answers

A patient is diagnosed with Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH) related to lung cancer. Which intervention is the priority for the nurse?

<p>Implementing fluid restriction. (D)</p> Signup and view all the answers

A patient is being treated for SIADH with hypertonic saline (3%). Which assessment finding requires the most immediate intervention?

<p>Crackles auscultated in the lungs. (A)</p> Signup and view all the answers

A patient is scheduled for a transsphenoidal hypophysectomy. Which preoperative instruction should the nurse emphasize to the patient?

<p>Avoidance of coughing or sneezing postoperatively. (B)</p> Signup and view all the answers

Following a transsphenoidal hypophysectomy, a patient reports a persistent headache and the nurse notes clear nasal drainage. What is the nurse's priority action?

<p>Test the nasal drainage for glucose. (D)</p> Signup and view all the answers

A patient is being discharged after a transsphenoidal hypophysectomy. Which long-term education point is most important for the nurse to emphasize?

<p>The need for lifelong hormone replacement therapy. (A)</p> Signup and view all the answers

The hypothalamus releases thyrotropin-releasing hormone (TRH), which stimulates the pituitary gland to release thyroid-stimulating hormone (TSH). What is the primary role of TSH?

<p>To stimulate the thyroid gland to release T3 and T4. (C)</p> Signup and view all the answers

A patient has a tumor that is causing excessive secretion of calcitonin. Which laboratory finding would the nurse expect to see?

<p>Decreased serum calcium levels. (A)</p> Signup and view all the answers

A patient with a known pituitary tumor is admitted for treatment of SIADH. Which medication from the patient's home medication list should the nurse question?

<p>Thiazide diuretic. (A)</p> Signup and view all the answers

Following a transsphenoidal hypophysectomy, a patient is at risk for developing diabetes insipidus (DI). Which assessment finding would indicate the development of DI?

<p>Increased thirst with profound urine output and dilute urine. (D)</p> Signup and view all the answers

Flashcards

Hormones

Chemical transmitters that regulate body functions by acting on target sites.

Hypothalamus

Controls release of pituitary hormones.

Growth Hormone (GH)

Stimulates growth of bone and muscle; promotes protein synthesis and fat metabolism.

Adrenocorticotropic Hormone (ACTH)

Stimulates synthesis and secretion of adrenal cortical hormones.

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Thyroid-Stimulating Hormone (TSH)

Stimulates synthesis and secretion of thyroid hormones.

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Antidiuretic Hormone (ADH)

Increases water reabsorption by kidney.

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Hypopituitarism

Hyposecretion of one or more pituitary hormones.

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Panhypopituitarism

Loss of all pituitary hormones.

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Pituitary Tumors

Benign tumors in the pituitary gland that can cause oversecretion or undersecretion of hormones.

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Giantism

Excess growth hormone BEFORE the closure of the growth plates, leading to increased height.

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Acromegaly

Oversecretion of growth hormone AFTER the closure of growth plates, leading to bone and soft tissue overgrowth.

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Diabetes Insipidus (DI)

A condition caused by insufficient ADH, leading to excessive thirst and large amounts of dilute urine.

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SIADH (Syndrome of Inappropriate Antidiuretic Hormone)

A condition due to excess ADH, causing water retention, hyponatremia, and concentrated urine.

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SIADH

Excessive secretion of antidiuretic hormone (ADH).

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SIADH Clinical Manifestations

Neurological symptoms of hypervolemia, decreased urine output, concentrated urine, low serum osmolality, low serum sodium.

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SIADH Collaborative Care

Treat the underlying cause, restrict fluids, administer loop diuretics, and slowly replace sodium if levels are low. Monitor patient and weights closely.

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Causes of DI & SIADH

Head trauma, neurosurgery, radiation to pituitary, CNS infections, tumors.

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Primary Addison's Disease

Adrenal glands not functioning, often due to autoimmune destruction.

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Secondary Addison's Disease

Pituitary dysfunction leading to decreased ACTH production.

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Hormone Levels in Addison's

Low cortisol, aldosterone, estrogen/testosterone levels.

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Addison's Manifestations

Anorexia, nausea, vomiting, diarrhea, abdominal pain, weakness, fever.

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Bronze Skin in Addison's

Hyperpigmentation due to increased ACTH stimulating melanocytes.

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Addisonian Crisis Signs

Hypotension/shock, abdominal pain, fever, confusion, electrolyte imbalances.

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Addison's Collaborative Care

Replace glucocorticoids and mineralocorticoids, manage stress, maintain fluids, manage electrolytes.

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Addisonian Crisis Causes

Trauma, stress, infection, or surgery in patients with adrenal insufficiency.

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Hypophysectomy

A procedure involving the partial or complete removal of the pituitary gland.

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Indications for Hypophysectomy

Pituitary tumors, diabetic retinopathy, and metastatic breast or prostate cancer.

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Approaches to Hypophysectomy

Craniotomy and transsphenoidal (most common).

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Post-op Care: Transsphenoidal Hypophysectomy

Monitor for hormone deficiencies, elevate HOB, manage headaches, avoid actions that increase pressure, and watch for CSF leaks.

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CSF Leak Indication

Clear nasal drainage that tests positive for glucose.

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Long-Term Management After Hypophysectomy

Lifelong hormone replacement therapy.

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Hypothalamus Hormone (Thyroid)

Thyrotropin-releasing hormone (TRH).

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TSH Function

Stimulates the thyroid to release T3, T4, and calcitonin.

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Thyroid Hormones Function

T3 and T4 regulate metabolism; calcitonin lowers serum calcium.

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Calcitonin Action

Released in response to high serum calcium levels, increasing calcium deposition in bone.

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Primary Hypothyroidism

Low T3, T4; High TSH (thyroid issue). Pituitary stimulates, thyroid fails.

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Secondary Hypothyroidism

Low T3, T4; Low TSH (pituitary issue). Pituitary doesn't stimulate thyroid.

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Hashimoto's Thyroiditis

Autoimmune destruction of thyroid, leading to low thyroid hormone.

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Myxedema Coma

Severe hypothyroidism leading to decompensation.

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Hyperthyroidism Labs

Low TSH; High T3 & T4. Overproduction of thyroid hormones.

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Grave's Disease

Autoimmune disorder causing overproduction of thyroid hormone.

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Thyroid Storm

Life-threatening exacerbation of hyperthyroidism.

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Exophthalmos

Bulging of the eyes, often seen in hyperthyroidism.

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Goiter

Enlargement of the thyroid gland.

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Thyroidectomy

Surgical removal of all or part of the thyroid gland.

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Hypocalcemia

Low calcium levels.

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Parathyroid Hormone (PTH)

Essential for calcium and phosphorus regulation.

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Hypoparathyroidism

Inadequate PTH leading to hypocalcemia.

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Hyperparathyroidism

Excess PTH causing bone demineralization and hypercalcemia.

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Cushing's Syndrome/Disease

Excess cortisol due to adrenal or pituitary issues, or steroid use.

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Study Notes

Module 2: Non-Diabetic Endocrine Disorders

  • Focuses on endocrine disorders other than Diabetes mellitus
  • The Endocrine system has organs include the hypothalamus, pineal gland, Pituitary (hypophysis), Thyroid, Parathyroid (posterior), Thymus, Adrenals, Islets of Langerhans (in pancreas), Testes and Ovaries.

Endocrine System Overview

  • Hormones are chemical messengers that regulate and integrate body functions
  • Hormones act on local or distant target sites.
  • They work with the nervous system to finely control organ function

Hypothalamus and Pituitary Glands

  • The hypothalamus releases and inhibits hormones that control the pituitary hormones
  • Corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone (TRH), and growth hormone-releasing hormone (GHRH) are specific Hypothalamus hormones.
  • The anterior Pituitary gland produces Growth hormone (GH); that stimulates bone and muscle growth
  • Adrenocorticotropic hormone (ACTH) is created by the anterior Pituitary, which stimulates synthesis and secretion of adrenal cortical hormones
  • Thyroid-stimulating hormone (TSH) is made by the Ant Pituitary, and stimulates synthesis and secretion of thyroid hormones
  • The posterior pituitary produces antidiuretic hormone (ADH)
  • Antidiuretic hormone (ADH) is also called Vasopressin

Hypopituitarianism/Pituitary Insufficiency

  • Hypopituitarism involves the hyposecretion of 1+ pituitary hormones
  • Etiologies include tumors, infarction, trauma, and radiation
  • The hormones are impacted based on impact location in the Pituitary
  • Losing all pituitary hormones, is rare, is called Panhypopituitarianism
  • Collaborative care includes identifying the cause and treating it
  • Collaborative care includes replacing deficient hormones
  • Collaborate with patients, and educate them about hormone replacement and signs and symptoms of hormone excess or deficiencies

Pituitary Tumors

  • Pituitary tumors are almost all begin
  • Tumors can cause oversecretion of growth hormones, resulting in Gigantism or Acromegaly
  • Tumors can cause oversecretion of ACTH, resulting in Cushing's
  • Some tumors can cause undersecretion of all pituitary hormones which happens in 90% of pituitary tumors
  • Tumors cause undersecretion because they don't produce hormones, but they destroy the pituitary's ability to release other hormons
  • The undersecretion leads to hypopituitarianisn

Posterior Pituitary: Antidiuretic Hormone Disorders (ADH/Vasopressin)

  • Diabetes Insipidus (DI) results from insufficient ADH
  • Syndrom of Inappropriate Antidiuretic Hormone (SIADH) occurs because of excess ADH

Diabetes Insipidus (DI)

  • Insufficient ADH
  • Causes include head trauma, neurosurgery, radiation of the pituitary or brain, CNS infections, or tumor
  • Clinical manifestations are thirst, profound urine output (over 250 mL per hours), and dilute urine
  • Hypovolemia, high serum osmolality and serum sodium, and Low urine osmolarity are also clinical manifestations
  • Interventions are treat the cause and replace ADH which is managed with Desmopressin (a synthetic vasopressin), fluid replacement, I and O monitoring, ensure pt. education, and take preventative and emergency measures
  • Patients should wear medical ID at all times in case of emergancy

SIADH

  • Excess ADH
  • Causes include head truama, neurosurgery, radiation, infection, malignant cells, lung disorders, and medications
  • Clinical manifestations are neurological symptoms of Hypervolemia
  • Decreased urine output, concentrated urine, hypervolemia and low serum osmolality, low serum sodium and high urine osmolality
  • Interventions: treat the cause, slow the sodium replacement, loop diuretics, fluid restriction, I and O measures, neurologic monitoring, seizure precautions, skin care with edema, noting that ongoing cases are rare

Hypophysectomy

  • Definition: Partial or complete removal of the pituitary gland
  • Indications: Pituitary tumors, diabetic retinopathy, metastatic breast and prostate cancer
  • Approaches include craniotomy and transphenoidal (most common)
  • Post op care for trandphenoidal hypohysectomy, monitor for target organ deficiencies, HOB elevated to 30, treat headaches, avoid tooth brushing, don't sneeze Observe for CSF leak from the nose (clear drainage, drainage tests positive for glucose), elevate HOB and call MD
  • Patient education: hormone replacement, and a medical id bracelet.

Thyroid Disorders

  • Disorders of the thyroid

Thyroid Hormones

  • The hypothalamus produces thyrotropin-releasing hormone (TRH), stimulating the pituitary to release thyroid stimulating hormone (TSH)
  • TSH stimulates the thyroid to produce hormones T3/4
  • T3 has four iodine atoms in each molecule, and T4 contains three iodine atoms in each molecule
  • Calcitonin is also produced by the thyroid
  • Calcitonin is released in response to high serum calcium
  • Calcitonin reduces plasma calcium by increasing its deposition in bone
  • Think of the thyroid as metabolism

Hypothyroidism

  • Inadequate TSH release (Pituitary problem), results in failure for thyroid to be stimulated , has low TSH and T3/4, secondary hypothyroidism
  • Thyroid problem, TSH released from pituitary, thyroid does not respond, so the pituitary increases TSH. Has a high TSH and low T3/4, is primary hypothyroidism

Hypothyroidism Manifestations

  • Pathology: insufficient production of thyroid, slowing of metabolis
  • Hashimotos thyroiditis, post treatment for graves disease are common forms.
  • General: Cold intolerant, lethargic weak, weight gain, forgetful and depression CNS: muscle exhaustion, cognitive slowing and short term memory loss
  • HEENT: dull expression, thin hair and dry, coarse scaly skin, periorbital edema, a goiter can be present

Hypothyroidism: CV Manifestations

  • Bradycardia
  • Elevated cholesterol
  • Atherosclerosis
  • Risks of acute coronary syndrome
  • Left Ventricular Dysfunction
  • GI: Decreased bowel sounds, constipation/impaction, fluid retention and anorexia

Hypothyroidism: Reproductive/Labs/Management

  • Reproductive: in females, Heavy/prolonged periods, and in males, impotence
  • Labs: low T3 & T4, high TSH in Primary
  • Low T3 & T4, Low TSH in secondary
  • Management: hormone replacement, low calorie foods
  • Myxedema/myxedema coma can occur; also at risk for acute coronary syndrome

Hyperthyroidism

  • Low TSH and high T3/4 causes overproduction from the thyroid suppressing the production of TSH

Hyperthyroidism-Manifestations/Labs/Management

  • Pathology: overproduction of hormones
  • Common forms, Graves
  • General: heat intolerant, nervous, hyperactive, weight loss, and insomnia
  • Increased DTRS
  • HEENT: Bulging eyes, fine soft hair, sweating, and eyelid lag and stare
  • CV: Tachycardia, bounding pulse, a-fib
  • Labs: T3/4 increased, TSH decreased
  • Management: antithyroid drugs, radioactive iodine and thyroidectomy

Exophthalmos

  • Bulging eyes

Thyroid Tumors

  • If the thyroid is enlarged, it becomes a goiter, and can enlarge due to iodine or a cancerous process.
  • Nodular goiter is the most common benign goiter

Thyroidectomy

  • Definition is removal of the thyroid, partial or total
  • Done for patients who can not take antithyroid medication, large goiter or cancerous modules
  • Postop focus on frequent calcium levels and montoring
  • Watch for airway obstruction
  • Watch for s/s of hyper/hypocalcemia

Parathyroid Disorders

  • Superior and inferior parathyroids

Parathyroid Hormone

  • Essential to calcium and phosphorous regulation
  • Low Calcium = PTH Release
  • Stimulates intestines vitamin D, and Bones demineralize
  • High Calcium = No PTH Release

Parathyorid Physiology

  • Low serum calcium, and enhanced vitmain D stimulates PTH which releases and absorbs vit d in the kidneys Normal serum calcium levels are needed

Parathyroid Disorders

  • Hypo: there is low levels of PTH and symptoms of hypercalcemia

Adrenal Disorders

Adrenal Cortex Hormones

  • Corticosteroids for stres adaptation, released in response to ACTH
  • Cortisol to influence glucose metabilosm, Mobilize fat stores, Long term negative effects
  • Mineralocorticosteroids, aldosterone, sodium adn potassium
  • Androgens-sech hormones

Cushing's

  • Syndrome: adrenal gland tumors, prolonged corticosteroid use
  • Redistribution of fat to the abdomen, insulin resistance, hirsutism, wound healing is poor because of normal response to infection
  • Truncal obseity, thin legs, muscle weakness and hyperglycemia
  • Labs: hyerglycemia, hypokalemis, leukocytosis
  • Treatment: adrenalectomies and potassium replacements steroids to maintain balance

Addison's

  • Adranalectomy, illness stress, abrubt steroid cessation.
  • Primary: adrenals not functioning;
  • low cortisol and esterogen
  • anorexia, nausea, weakness
  • Labs: decrease cortisol and increase potassium
  • Treat: Replace glucorticods and steriods, watch electrolytes
  • Addisonian and Adrenal Crisis: insufficnet levels of cortisol-hypotension, severe pain, confusion. Treat shock, manage fever and stabalize mental states.
  • With Steriod therapy, reduce cortisol levels to avoid crisis, and the patient is more susceptible to stress.

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