24 Questions
What is one of the functions of the skin?
Prevent insensible water loss
Which cells are part of the skin's immune system?
Langerhans cells and dermal DC
What is the role of Tregs in the skin immune system?
Regulate immune responses
What is the main function of mast cells in the skin?
Release histamine and other inflammatory mediators
What does the term 'Dermatitis' refer to?
Inflamed skin
Which type of immune response is responsible for Allergic Contact Dermatitis?
Type IV immune response
What is the most common manifestation of immunotoxicity in humans with Allergic Contact Dermatitis?
Erythema, itching, and vesicles
What are some risk factors for developing contact allergy to at least one contact allergen?
Workplace exposure, age, sex, and genetic predispositions
Which type of chemicals are most commonly responsible for causing Allergic Contact Dermatitis?
Low molecular weight chemicals
What is the prevalence of Allergic Contact Dermatitis in 12–16 year olds?
$15-20%$
What is the current view regarding the chances to develop hypersensitivity towards chemicals?
It depends on a balance between hapten-specific effector T cells and Treg lymphocytes
What does LC stands for?
Langerhans Cells
What is the cardinal feature of inflammation referring to increased blood flow?
Calor (heat)
Which immune cells are responsible for T cell priming in the pathophysiology of Allergic Contact Dermatitis?
Dendritic cells
What is the most common manifestation of immunotoxicity in humans with Allergic Contact Dermatitis?
Blistering and itching
What is the primary risk factor for developing contact allergy to at least one contact allergen?
Genetic predispositions
Which type of immune response is responsible for Allergic Contact Dermatitis?
Type IV immune response
What is the cardinal feature of inflammation referring to irritation of nerves in inflamed tissues?
Dolor
What is the role of dendritic cells in the pathophysiology of Allergic Contact Dermatitis?
Activation of keratinocytes
Which cells are responsible for priming T cells in the pathophysiology of Allergic Contact Dermatitis?
Langerhans cells and dermal DC
What are the primary constituents of innate immunity in the skin?
Langerhans cells and dermal DC
Which type of immune response is primarily responsible for Allergic Contact Dermatitis?
Cell-mediated immune response
What is the main function of mast cells in the context of skin immune system?
Release of inflammatory mediators
What are the main functions of the skin, apart from acting as a physical barrier?
Preventing insensible water loss and controlling body temperature
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