Questions and Answers
Autoimmune diseases occur due to the immune system attacking non-self cells
False
Autoimmune diseases can be directed against a very specific tissue or a large number of tissues
True
More women than men are affected by autoimmune diseases
True
Autoimmune diseases are caused by the presence of autoantibodies or autoreactive cells
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The immune system ensures self-tolerance by promoting the development of auto-reactive lymphocytes
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Rheumatoid arthritis is an example of an immunodeficiency disease.
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Rheumatism only affects the joints and not the connective tissue.
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MHC class I genes are associated with Rheumatoid Arthritis.
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Viral infections are not considered as environmental factors that predispose to Rheumatologic Diseases.
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Chronic Arthritis is a term used to describe the long-term inflammation of a joint.
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Study Notes
- Autoimmune diseases are abnormal conditions where self-cells are attacked by autoantibodies or autoreactive cells
- Immune system normally eliminates auto-reactive lymphocytes during development, but this process fails in autoimmune diseases
- Attack can be humoral (by auto-antibodies) or cellular (by auto-reactive T cells)
- Can be specific to a tissue or systemic, depending on the self-antigen targeted
- Prevalence: 5-7% of adults are affected, with two thirds being women. Over 80 human diseases have autoimmune origins.
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