Clinical Immunology: Autoimmune Diseases
20 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary mechanism of Type 2 Hypersensitivity Reaction?

  • Release of histamine from mast cells and basophils
  • Activation of T cytotoxic and T helper cells by an antigen presenting cells
  • Antibody-antigen complex formation leading to complement activation (correct)
  • Recognition of an antigen by T memory cells leading to macrophage activation

Which of the following is NOT an example of Type 3 Hypersensitivity Reaction?

  • Post streptococcal glomerulonephritis
  • Contact dermatitis (correct)
  • Serum sickness
  • Rheumatoid arthritis

What is the primary function of T memory cells in Type 4 Hypersensitivity Reaction?

  • Recognizing and binding to antigens (correct)
  • Producing antibodies against antigens
  • Activating macrophages and inducing tissue damage
  • Releasing histamine and causing allergic reactions

Which type of hypersensitivity reaction is characterized by the formation of immune complexes?

<p>Type 3 (D)</p> Signup and view all the answers

What is the primary difference between Type 2 and Type 3 Hypersensitivity Reactions?

<p>The location of antigen-antibody complex formation (A)</p> Signup and view all the answers

Which of the following is an example of Type 2 Hypersensitivity Reaction?

<p>Rheumatic heart disease (D)</p> Signup and view all the answers

What is autoimmunity defined as?

<p>Development of immune responses against self tissue (antigen). (B)</p> Signup and view all the answers

What is the normal process that prevents autoimmunity?

<p>Clonal deletion of self-reactive T and B lymphocytes during intrauterine life. (B)</p> Signup and view all the answers

Which of the following is NOT a predisposing factor for autoimmunity?

<p>Age (A)</p> Signup and view all the answers

What is the classification of autoimmune diseases based on the extent of tissue damage?

<p>Organ-specific and multi-system (D)</p> Signup and view all the answers

Which of the following is an example of an organ-specific autoimmune disease?

<p>Hashimoto disease (B)</p> Signup and view all the answers

What is the mechanism of tissue damage in type 1 hypersensitivity reaction?

<p>Release of vasoactive biomolecules from mast cells and basophils (C)</p> Signup and view all the answers

Which of the following is NOT an example of a multi-system autoimmune disease?

<p>Primary biliary cholangitis (PBC) (D)</p> Signup and view all the answers

What is the role of HLA type in autoimmunity?

<p>HLA type is a predisposing factor for autoimmunity (A)</p> Signup and view all the answers

What is the mechanism of tissue damage in Type II autoimmunity?

<p>Binding of IgG or IgM to antigens on the surface of cells (A)</p> Signup and view all the answers

Which of the following is a general feature of autoimmunity?

<p>Onset with emotional instability or hormonal changes (C)</p> Signup and view all the answers

What is the primary mechanism of tissue damage in Type IV autoimmunity?

<p>Activation of T cells, phagocytes, or NK cells (A)</p> Signup and view all the answers

Which of the following autoimmune disorders is characterized by the formation of immune complexes and activation of complement?

<p>Systemic lupus erythematosus (SLE) (B)</p> Signup and view all the answers

What is the significance of a positive antinuclear antibody (ANA) test in autoimmunity?

<p>It is a good screening test for autoimmune disorders (B)</p> Signup and view all the answers

Which of the following is a characteristic of Type I autoimmunity?

<p>IgE-mediated mast cell activation (C)</p> Signup and view all the answers
Use Quizgecko on...
Browser
Browser