20 Questions
What is the primary mechanism of Type 2 Hypersensitivity Reaction?
Antibody-antigen complex formation leading to complement activation
Which of the following is NOT an example of Type 3 Hypersensitivity Reaction?
Contact dermatitis
What is the primary function of T memory cells in Type 4 Hypersensitivity Reaction?
Recognizing and binding to antigens
Which type of hypersensitivity reaction is characterized by the formation of immune complexes?
Type 3
What is the primary difference between Type 2 and Type 3 Hypersensitivity Reactions?
The location of antigen-antibody complex formation
Which of the following is an example of Type 2 Hypersensitivity Reaction?
Rheumatic heart disease
What is autoimmunity defined as?
Development of immune responses against self tissue (antigen).
What is the normal process that prevents autoimmunity?
Clonal deletion of self-reactive T and B lymphocytes during intrauterine life.
Which of the following is NOT a predisposing factor for autoimmunity?
Age
What is the classification of autoimmune diseases based on the extent of tissue damage?
Organ-specific and multi-system
Which of the following is an example of an organ-specific autoimmune disease?
Hashimoto disease
What is the mechanism of tissue damage in type 1 hypersensitivity reaction?
Release of vasoactive biomolecules from mast cells and basophils
Which of the following is NOT an example of a multi-system autoimmune disease?
Primary biliary cholangitis (PBC)
What is the role of HLA type in autoimmunity?
HLA type is a predisposing factor for autoimmunity
What is the mechanism of tissue damage in Type II autoimmunity?
Binding of IgG or IgM to antigens on the surface of cells
Which of the following is a general feature of autoimmunity?
Onset with emotional instability or hormonal changes
What is the primary mechanism of tissue damage in Type IV autoimmunity?
Activation of T cells, phagocytes, or NK cells
Which of the following autoimmune disorders is characterized by the formation of immune complexes and activation of complement?
Systemic lupus erythematosus (SLE)
What is the significance of a positive antinuclear antibody (ANA) test in autoimmunity?
It is a good screening test for autoimmune disorders
Which of the following is a characteristic of Type I autoimmunity?
IgE-mediated mast cell activation
Learn about the immune system disorders, autoimmune diseases, and autoimmunity. Understand how the immune system responds to self-tissue and the presence of autoantibodies. A fundamental concept in clinical immunology.
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