Understanding Anticancer Drugs
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Questions and Answers

What is the term used for the physiological process through which new blood vessels form from pre-existing vessels?

  • Invasion
  • Angiogenesis (correct)
  • Apoptosis
  • Metastasis

    • What is the difference between cancer cells and normal cells?

  • Cancer cells do not divide, while normal cells continue to grow and divide in a disorderly fashion.
  • Normal cells grow, divide, and die in an orderly fashion, while cancer cells do not die and continue to grow and divide in a disorderly fashion. (correct)
  • Cancer cells grow, divide, and die in an orderly fashion, while normal cells do not die and continue to grow and divide in a disorderly fashion.
  • Normal cells do not divide, while cancer cells grow, divide, and die in an orderly fashion.

    • Which process provides the tumor cell with sufficient nutrients and oxygen supply for its growth?

  • Invasion
  • Apoptosis
  • Angiogenesis (correct)
  • Metastasis

    • What is responsible for the removal of damaged or unnecessary cells through programmed cell death?

    <p>Apoptosis</p> Signup and view all the answers

    What is the direct extension and penetration by cancer cells into neighbouring tissues called?

    <p>Invasion</p> Signup and view all the answers

    Which series of events cause a cell to divide into two daughter cells?

    <p>The cell cycle</p> Signup and view all the answers

    What is the phase of the cell cycle where DNA replication occurs?

    <p>S phase</p> Signup and view all the answers

    Which phase of the cell cycle involves the division of the cell's nucleus?

    <p>M phase</p> Signup and view all the answers

    Which classification of cytotoxic drugs acts on all proliferating phases, including the G0 phase?

    <p>Cell Cycle Non specific (CCNS)</p> Signup and view all the answers

    Which class of cytotoxic drugs directly acts on rapidly dividing cells and is highly toxic to cells?

    <p>Alkylating Agents</p> Signup and view all the answers

    Which cytotoxic drug class disrupts DNA by forming covalent bonds between drug alkyl groups and DNA bases?

    <p>Nitrogen Mustards</p> Signup and view all the answers

    Which phase of the cell cycle is known as the growth phase?

    <p>G1 phase</p> Signup and view all the answers

    Which type of toxicity is a common side effect of most anticancer drugs?

    <p>Bone marrow suppression</p> Signup and view all the answers

    Which classification of cytotoxic drugs acts on a specific phase of the cell cycle?

    <p>Cell Cycle Specific (CCS)</p> Signup and view all the answers

    Which phase of the cell cycle do antimetabolites act on?

    <p>S phase</p> Signup and view all the answers

    What is the mechanism of action of topoisomerase inhibitors?

    <p>Blockage of DNA replication in S phase</p> Signup and view all the answers

    Which class of cytotoxic drugs disrupts the microtubule structure during mitosis?

    <p>Antitubulin Agents</p> Signup and view all the answers

    What is the mode of action of Vinca alkaloids like Vinblastine and Vincristine?

    <p>Prevention of microtubule formation in M phase</p> Signup and view all the answers

    Which drug class binds to tubulin and prevents microtubule formation, resulting in dissolution of the mitotic spindle?

    <p>Vincristine</p> Signup and view all the answers

    What is the mechanism of action of Topotecan and Irinotecan, which are specific to the S-phase?

    <p>Inhibition of topoisomerase enzyme</p> Signup and view all the answers

    Which drug causes bone marrow suppression and serious hypersensitivity reactions, necessitating premedication with dexamethasone and diphenhydramine?

    <p>Paclitaxel</p> Signup and view all the answers

    Which drug is specific to late S & early G2 phase and inhibits the resealing step of DNA replication?

    <p>Etoposide</p> Signup and view all the answers

    What is the primary toxic effect associated with Irinotecan?

    <p>Acute and delayed life-threatening diarrhea</p> Signup and view all the answers

    Which drug acts by preventing the assembly of tubulin and preventing microtubule formation?

    <p>Docetaxel</p> Signup and view all the answers

    What is the dose-limiting toxicity associated with Topotecan?

    <p>Myelosuppression</p> Signup and view all the answers

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