Understanding Anticancer Drugs

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What is the term used for the physiological process through which new blood vessels form from pre-existing vessels?

Invasion

Angiogenesis (correct)

Apoptosis

Metastasis

What is the difference between cancer cells and normal cells?

Cancer cells do not divide, while normal cells continue to grow and divide in a disorderly fashion.

Normal cells grow, divide, and die in an orderly fashion, while cancer cells do not die and continue to grow and divide in a disorderly fashion. (correct)

Cancer cells grow, divide, and die in an orderly fashion, while normal cells do not die and continue to grow and divide in a disorderly fashion.

Normal cells do not divide, while cancer cells grow, divide, and die in an orderly fashion.

Which process provides the tumor cell with sufficient nutrients and oxygen supply for its growth?

Invasion

Apoptosis

Angiogenesis (correct)

Metastasis

What is responsible for the removal of damaged or unnecessary cells through programmed cell death?

Apoptosis Signup and view all the answers

What is the direct extension and penetration by cancer cells into neighbouring tissues called?

Invasion Signup and view all the answers

Which series of events cause a cell to divide into two daughter cells?

The cell cycle Signup and view all the answers

What is the phase of the cell cycle where DNA replication occurs?

S phase Signup and view all the answers

Which phase of the cell cycle involves the division of the cell's nucleus?

M phase Signup and view all the answers

Which classification of cytotoxic drugs acts on all proliferating phases, including the G0 phase?

Cell Cycle Non specific (CCNS) Signup and view all the answers

Which class of cytotoxic drugs directly acts on rapidly dividing cells and is highly toxic to cells?

Alkylating Agents Signup and view all the answers

Which cytotoxic drug class disrupts DNA by forming covalent bonds between drug alkyl groups and DNA bases?

Nitrogen Mustards Signup and view all the answers

Which phase of the cell cycle is known as the growth phase?

G1 phase Signup and view all the answers

Which type of toxicity is a common side effect of most anticancer drugs?

Bone marrow suppression Signup and view all the answers

Which classification of cytotoxic drugs acts on a specific phase of the cell cycle?

Cell Cycle Specific (CCS) Signup and view all the answers

Which phase of the cell cycle do antimetabolites act on?

S phase Signup and view all the answers

What is the mechanism of action of topoisomerase inhibitors?

Blockage of DNA replication in S phase Signup and view all the answers

Which class of cytotoxic drugs disrupts the microtubule structure during mitosis?

Antitubulin Agents Signup and view all the answers

What is the mode of action of Vinca alkaloids like Vinblastine and Vincristine?

Prevention of microtubule formation in M phase Signup and view all the answers

Which drug class binds to tubulin and prevents microtubule formation, resulting in dissolution of the mitotic spindle?

Vincristine Signup and view all the answers

What is the mechanism of action of Topotecan and Irinotecan, which are specific to the S-phase?

Inhibition of topoisomerase enzyme Signup and view all the answers

Which drug causes bone marrow suppression and serious hypersensitivity reactions, necessitating premedication with dexamethasone and diphenhydramine?

Paclitaxel Signup and view all the answers

Which drug is specific to late S & early G2 phase and inhibits the resealing step of DNA replication?

Etoposide Signup and view all the answers

What is the primary toxic effect associated with Irinotecan?

Acute and delayed life-threatening diarrhea Signup and view all the answers

Which drug acts by preventing the assembly of tubulin and preventing microtubule formation?

Docetaxel Signup and view all the answers

What is the dose-limiting toxicity associated with Topotecan?

Myelosuppression Signup and view all the answers