Podcast
Questions and Answers
How does insulin lispro differ from regular human insulin?
How does insulin lispro differ from regular human insulin?
- Insulin lispro has proline and lysine at positions β28 and β29, while regular human insulin has lysine and proline at those positions. (correct)
- Insulin lispro has lysine at position β29, while regular human insulin has asparagine at that position.
- Insulin lispro has lysine at position β29, while regular human insulin has glutamic acid at that position.
- Insulin lispro has aspartic acid at position β28, while regular human insulin has proline at that position.
What is the function of the amino acid substitution in insulin aspart at position β28?
What is the function of the amino acid substitution in insulin aspart at position β28?
- Facilitates absorption by preventing aggregation into hexamers and dimers. (correct)
- Increases the duration of action to 5 to 7 hours.
- Enhances dissociation into monomers, allowing rapid absorption.
- Stabilizes the insulin in normal saline for IV use.
Why is insulin glulisine considered suitable for IV use only in normal saline?
Why is insulin glulisine considered suitable for IV use only in normal saline?
- Saline allows insulin glulisine to dissociate into monomers more effectively.
- Other solutions cause insulin glulisine to degrade rapidly.
- It needs the stabilizing effect of saline to prevent degradation. (correct)
- Insulin glulisine is more potent when administered in a saline solution.
Which insulin analog has a duration of action similar to regular crystalline insulin?
Which insulin analog has a duration of action similar to regular crystalline insulin?
What makes the three ultra-rapid acting insulins (lispro, aspart, glulisine) unique in terms of onset compared to regular crystalline insulin?
What makes the three ultra-rapid acting insulins (lispro, aspart, glulisine) unique in terms of onset compared to regular crystalline insulin?
What distinguishes Humalog® (insulin lispro) from regular human insulin in terms of amino acid sequence?
What distinguishes Humalog® (insulin lispro) from regular human insulin in terms of amino acid sequence?
What is the primary similarity in the mechanism of action of nateglinide and repaglinide?
What is the primary similarity in the mechanism of action of nateglinide and repaglinide?
What is a key difference in the pharmacokinetics between nateglinide and repaglinide?
What is a key difference in the pharmacokinetics between nateglinide and repaglinide?
Why are meglitinides like nateglinide and repaglinide administered shortly before a meal?
Why are meglitinides like nateglinide and repaglinide administered shortly before a meal?
What is a common adverse effect associated with meglitinides like nateglinide and repaglinide?
What is a common adverse effect associated with meglitinides like nateglinide and repaglinide?
In what way do nateglinide and repaglinide differ in terms of excretion?
In what way do nateglinide and repaglinide differ in terms of excretion?
Why is repaglinide contraindicated in patients taking gemfibrozil?
Why is repaglinide contraindicated in patients taking gemfibrozil?
What modification is made to the alpha-chain of human insulin to create insulin glargine?
What modification is made to the alpha-chain of human insulin to create insulin glargine?
Why does insulin glargine have a longer duration of action than NPH insulin?
Why does insulin glargine have a longer duration of action than NPH insulin?
What is unique about the solution of insulin glargine?
What is unique about the solution of insulin glargine?
What is the approximate onset of action of insulin glargine?
What is the approximate onset of action of insulin glargine?
Why is insulin glargine administered once a day?
Why is insulin glargine administered once a day?
What is important to note when mixing insulins with insulin glargine?
What is important to note when mixing insulins with insulin glargine?
