Insulin Aspart Flashcards

Study Notes

Therapeutic and Pharmaceutical Classes

Classified as antidiabetics and hormones.
Falls under the pharmaceutical class of pancreatic medications.

Indications

Used for controlling hyperglycemia in both type 1 and type 2 diabetes mellitus patients.

Mechanism of Action

Lowers blood glucose levels by:
- Stimulating glucose uptake in skeletal muscle and adipose tissue.
- Inhibiting hepatic glucose production.
Also inhibits lipolysis and proteolysis while enhancing protein synthesis.
Considered a rapid-acting insulin with a quicker onset and shorter duration compared to human regular insulin.
Should be administered alongside intermediate or long-acting insulin for effective results.

Pharmacokinetics

Onset of action: approximately 15 minutes.
Peak effect: reached in about 1 hour.
Duration of action: lasts for approximately 3 hours.

Contraindications and Precautions

Contraindicated in cases of:
- Hypoglycemia.
- Allergy or hypersensitivity to insulin aspart.
Cautiously used in patients experiencing:
- Stress and infections, which can increase insulin requirements.
- Renal or hepatic impairment, possibly decreasing insulin needs.
Must always be combined with a longer-acting insulin for type 1 diabetes management.
Risk of worsened heart failure and fluid retention when used alongside pioglitazone or rosiglitazone.
Pregnant patients may experience increased insulin needs temporarily.
Special consideration is given to pediatric patients.

Description

This quiz focuses on key concepts related to Insulin Aspart, including its therapeutic and pharmaceutical classes, indications, and action mechanism. Ideal for medical students and healthcare professionals who want to enhance their understanding of diabetes management.