12 Questions
Which molecules are induced on the surface of the local blood vessel endothelium and on the infiltrating cells?
Selectins, integrins, ICAM/ImmG
What is the first step in the process of recruitment of cells to the site of infection?
Reversible adherence
What appears on the endothelial cell surface within minutes of exposure to inflammatory mediators?
P-selectin
What enables the engulfing of bacteria and the recruitment of cells to the site of infection?
Phagocytosis, cytokines, chemokines, activation of complement
Which molecules are involved in the activation of E-selectin transcription and expression on cell surface?
C5a and TNFa
Which molecules bind to ICAM1&2 on endothelium and trigger a conformational change on the rolling cell?
LFA-1 and CR3
Which molecule is expressed at junctions of endothelial cells and allows cells to squeeze through these junctions?
CD31
What is the role of chemokines in the migration of cells through tissue to the infection?
Increase adherence to endothelial cells
Which proteins are induced by IL-1/IL-6/TNF during the acute phase response?
Acute phase proteins
What is the function of C reactive protein during the acute phase response?
Opsonizes pathogens and triggers complement cascade
What is the main function of mannose binding lectin during the acute phase response?
Opsonizes pathogens
Which process enables the engulfing of bacteria and the recruitment of cells to the site of infection?
Phagocytosis
Test your knowledge of innate immunity in immunology with this quiz. Explore topics such as phagocytosis, cytokine and chemokine production, complement activation, adhesion molecules, and cell recruitment to infection sites.
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