Podcast
Questions and Answers
Phagocytic cells recognize pathogens through ______ receptor
Phagocytic cells recognize pathogens through ______ receptor
pattern recognition
TLR4 recognizes ______ (LPS)
TLR4 recognizes ______ (LPS)
lipopolysaccharide
Innate immunity provides first line of defence at ______ surfaces
Innate immunity provides first line of defence at ______ surfaces
epithelial
[Blank] proteins A & D found in lung fluid – they bind to and coat the surfaces of pathogens for phagocytosis by macrophages
[Blank] proteins A & D found in lung fluid – they bind to and coat the surfaces of pathogens for phagocytosis by macrophages
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Activation of TLRs triggers the production of ______, chemokines and the expression of co-stimulatory molecules
Activation of TLRs triggers the production of ______, chemokines and the expression of co-stimulatory molecules
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Phagocytosis is the process of engulfing and digesting ______
Phagocytosis is the process of engulfing and digesting ______
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______ is directly toxic to the pathogen
______ is directly toxic to the pathogen
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______ is a characteristic of components of pathogens at some stage of infection
______ is a characteristic of components of pathogens at some stage of infection
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TLR4 recognizes ______ (LPS)
TLR4 recognizes ______ (LPS)
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Innate immunity lacks ______ but can distinguish between self and non-self
Innate immunity lacks ______ but can distinguish between self and non-self
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______ proteins A & D found in lung fluid – they bind to and coat the surfaces of pathogens for phagocytosis by macrophages
______ proteins A & D found in lung fluid – they bind to and coat the surfaces of pathogens for phagocytosis by macrophages
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Phagocytic cells recognize pathogens through ______ receptor
Phagocytic cells recognize pathogens through ______ receptor
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TLR4 recognizes ______ (LPS)
TLR4 recognizes ______ (LPS)
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Innate immunity provides first line of defence at ______ surfaces
Innate immunity provides first line of defence at ______ surfaces
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Innate immunity lacks ______ but can distinguish between self and non-self
Innate immunity lacks ______ but can distinguish between self and non-self
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Pattern recognition receptors are clonally distributed like in adaptive immunity
Pattern recognition receptors are clonally distributed like in adaptive immunity
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Surfactant proteins A & D found in lung fluid bind to and coat the surfaces of pathogens for phagocytosis by macrophages
Surfactant proteins A & D found in lung fluid bind to and coat the surfaces of pathogens for phagocytosis by macrophages
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Phagocytosis involves the internalization of pathogens in a membrane-bound vesicle called a phagosome
Phagocytosis involves the internalization of pathogens in a membrane-bound vesicle called a phagosome
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Innate immunity lacks specificity but can distinguish between self and non-self as it recognizes patterns that are common to pathogens
Innate immunity lacks specificity but can distinguish between self and non-self as it recognizes patterns that are common to pathogens
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TLR4 recognizes lipopolysaccharide (LPS) - a cell wall component of gram-negative bacteria
TLR4 recognizes lipopolysaccharide (LPS) - a cell wall component of gram-negative bacteria
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Phagocytosis is the process of engulfing and digesting pathogens
Phagocytosis is the process of engulfing and digesting pathogens
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Mucosal surfaces and external epithelia are not part of the front line of host defense in innate immunity
Mucosal surfaces and external epithelia are not part of the front line of host defense in innate immunity
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Deficiency in the process of mucous expulsion is evident in cystic fibrosis
Deficiency in the process of mucous expulsion is evident in cystic fibrosis
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Pattern recognition receptors are clonally distributed like in adaptive immunity
Pattern recognition receptors are clonally distributed like in adaptive immunity
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Phospholipase A is not secreted in tears and saliva
Phospholipase A is not secreted in tears and saliva
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Innate immunity always causes clinical disease when pathogens get through epithelial barriers.
Innate immunity always causes clinical disease when pathogens get through epithelial barriers.
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Mucosal surfaces secrete mucus which contains glycoproteins called mucins.
Mucosal surfaces secrete mucus which contains glycoproteins called mucins.
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Deficiency in the process of expelling pathogens in the flow of mucus is evident in cystic fibrosis.
Deficiency in the process of expelling pathogens in the flow of mucus is evident in cystic fibrosis.
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Lysozyme and phospholipase A are secreted in tears and saliva.
Lysozyme and phospholipase A are secreted in tears and saliva.
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Innate immune mechanisms function only in the underlying tissue to prevent the establishment of infection.
Innate immune mechanisms function only in the underlying tissue to prevent the establishment of infection.
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