Innate Immunity Quiz
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Questions and Answers

Which molecule recognises certain glycoproteins on cells such as sulfated-sialyl-Lewisx?

  • Histamine
  • LPS
  • C5a (correct)
  • TNFa
  • Which molecules are involved in the adherence of cells to the vessel wall, allowing them to roll along the wall?

  • Chemokines
  • ICAM1&2
  • E-selectin
  • Integrins LFA-1 and CR3 (correct)
  • Which molecule is expressed at junctions of endothelial cells and allows cells to squeeze through these junctions?

  • CR3
  • CD31 (correct)
  • E-selectin
  • LFA-1
  • Which molecules are involved in the migration of cells through tissue to the infection site under the influence of chemokines?

    <p>Chemokines and integrins</p> Signup and view all the answers

    Which cytokines induce hepatocytes in the liver to synthesise acute phase proteins?

    <p>IL-1/IL-6/TNF</p> Signup and view all the answers

    Which protein binds to the phosphocholine portion of certain bacterial and fungal cell-wall lipopolysaccharide?

    <p>C reactive protein</p> Signup and view all the answers

    Which molecules are involved in the activation of complement cascade?

    <p>C reactive protein and mannose binding lectin</p> Signup and view all the answers

    Which molecules are involved in the recognition of bacteria through pattern recognition receptors?

    <p>Adhesion molecules</p> Signup and view all the answers

    Which cells are involved in lymphocyte development and antigen recognition?

    <p>T cells</p> Signup and view all the answers

    Which molecule is a pathogen recognition molecule that opsonizes pathogens and triggers the complement cascade?

    <p>Mannose binding lectin</p> Signup and view all the answers

    Which cells are involved in the engulfing of bacteria and the recruitment of cells to the site of infection?

    <p>Macrophages</p> Signup and view all the answers

    Which molecules are involved in the activation of the acute phase response?

    <p>Cytokines produced by macrophages</p> Signup and view all the answers

    Which molecules are induced on the surface of the local blood vessel endothelium and on the infiltrating cells?

    <p>Selectins, integrins, ICAM/ImmG</p> Signup and view all the answers

    What appears on the endothelial cell surface within minutes of exposure to inflammatory mediators?

    <p>P-selectin</p> Signup and view all the answers

    What enables the engulfing of bacteria and the recruitment of cells to the site of infection?

    <p>Phagocytosis, cytokines, chemokines, complement, adhesion molecules</p> Signup and view all the answers

    What is the first step in the process of recruitment of cells to the site of infection?

    <p>Reversible adherence</p> Signup and view all the answers

    What mediates the recruitment of cells to the site of infection?

    <p>Chemokines and cell-adhesion molecules</p> Signup and view all the answers

    What is induced on the surface of infiltrating cells and the local blood vessel endothelium?

    <p>Cell-adhesion molecules</p> Signup and view all the answers

    What family of molecules enables the first step of reversible adherence during the recruitment of cells to the site of infection?

    <p>Selectins</p> Signup and view all the answers

    What appears on the endothelial cell surface within minutes of exposure to inflammatory mediators?

    <p>P-selectin</p> Signup and view all the answers

    What type of adherence is enabled by selectins during the recruitment of cells to the site of infection?

    <p>Reversible</p> Signup and view all the answers

    What is the final step in the process of recruitment of cells to the site of infection?

    <p>Migration under the influence of chemokines</p> Signup and view all the answers

    What enables the cells to come out of the center of the blood vessel and interact with the endothelium at inflammatory sites?

    <p>Dilated vessels and slower blood flow</p> Signup and view all the answers

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