Innate Immunity Quiz

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23 Questions

Which molecule recognises certain glycoproteins on cells such as sulfated-sialyl-Lewisx?

C5a

Which molecules are involved in the adherence of cells to the vessel wall, allowing them to roll along the wall?

Integrins LFA-1 and CR3

Which molecule is expressed at junctions of endothelial cells and allows cells to squeeze through these junctions?

CD31

Which molecules are involved in the migration of cells through tissue to the infection site under the influence of chemokines?

Chemokines and integrins

Which cytokines induce hepatocytes in the liver to synthesise acute phase proteins?

IL-1/IL-6/TNF

Which protein binds to the phosphocholine portion of certain bacterial and fungal cell-wall lipopolysaccharide?

C reactive protein

Which molecules are involved in the activation of complement cascade?

C reactive protein and mannose binding lectin

Which molecules are involved in the recognition of bacteria through pattern recognition receptors?

Adhesion molecules

Which cells are involved in lymphocyte development and antigen recognition?

T cells

Which molecule is a pathogen recognition molecule that opsonizes pathogens and triggers the complement cascade?

Mannose binding lectin

Which cells are involved in the engulfing of bacteria and the recruitment of cells to the site of infection?

Macrophages

Which molecules are involved in the activation of the acute phase response?

Cytokines produced by macrophages

Which molecules are induced on the surface of the local blood vessel endothelium and on the infiltrating cells?

Selectins, integrins, ICAM/ImmG

What appears on the endothelial cell surface within minutes of exposure to inflammatory mediators?

P-selectin

What enables the engulfing of bacteria and the recruitment of cells to the site of infection?

Phagocytosis, cytokines, chemokines, complement, adhesion molecules

What is the first step in the process of recruitment of cells to the site of infection?

Reversible adherence

What mediates the recruitment of cells to the site of infection?

Chemokines and cell-adhesion molecules

What is induced on the surface of infiltrating cells and the local blood vessel endothelium?

Cell-adhesion molecules

What family of molecules enables the first step of reversible adherence during the recruitment of cells to the site of infection?

Selectins

What appears on the endothelial cell surface within minutes of exposure to inflammatory mediators?

P-selectin

What type of adherence is enabled by selectins during the recruitment of cells to the site of infection?

Reversible

What is the final step in the process of recruitment of cells to the site of infection?

Migration under the influence of chemokines

What enables the cells to come out of the center of the blood vessel and interact with the endothelium at inflammatory sites?

Dilated vessels and slower blood flow

Test your knowledge of innate immunity with this quiz covering topics such as phagocytosis, cytokine and chemokine production, complement activation, adhesion molecules, and cell recruitment to sites of infection. This quiz will help reinforce your understanding of the mechanisms involved in the body's initial response to bacterial invasion.

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