Innate Immunity Quiz

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Questions and Answers

Which molecule recognises certain glycoproteins on cells such as sulfated-sialyl-Lewisx?

  • Histamine
  • LPS
  • C5a (correct)
  • TNFa

Which molecules are involved in the adherence of cells to the vessel wall, allowing them to roll along the wall?

  • Chemokines
  • ICAM1&2
  • E-selectin
  • Integrins LFA-1 and CR3 (correct)

Which molecule is expressed at junctions of endothelial cells and allows cells to squeeze through these junctions?

  • CR3
  • CD31 (correct)
  • E-selectin
  • LFA-1

Which molecules are involved in the migration of cells through tissue to the infection site under the influence of chemokines?

<p>Chemokines and integrins (D)</p> Signup and view all the answers

Which cytokines induce hepatocytes in the liver to synthesise acute phase proteins?

<p>IL-1/IL-6/TNF (A)</p> Signup and view all the answers

Which protein binds to the phosphocholine portion of certain bacterial and fungal cell-wall lipopolysaccharide?

<p>C reactive protein (D)</p> Signup and view all the answers

Which molecules are involved in the activation of complement cascade?

<p>C reactive protein and mannose binding lectin (A)</p> Signup and view all the answers

Which molecules are involved in the recognition of bacteria through pattern recognition receptors?

<p>Adhesion molecules (C)</p> Signup and view all the answers

Which cells are involved in lymphocyte development and antigen recognition?

<p>T cells (D)</p> Signup and view all the answers

Which molecule is a pathogen recognition molecule that opsonizes pathogens and triggers the complement cascade?

<p>Mannose binding lectin (A)</p> Signup and view all the answers

Which cells are involved in the engulfing of bacteria and the recruitment of cells to the site of infection?

<p>Macrophages (A)</p> Signup and view all the answers

Which molecules are involved in the activation of the acute phase response?

<p>Cytokines produced by macrophages (D)</p> Signup and view all the answers

Which molecules are induced on the surface of the local blood vessel endothelium and on the infiltrating cells?

<p>Selectins, integrins, ICAM/ImmG (A)</p> Signup and view all the answers

What appears on the endothelial cell surface within minutes of exposure to inflammatory mediators?

<p>P-selectin (C)</p> Signup and view all the answers

What enables the engulfing of bacteria and the recruitment of cells to the site of infection?

<p>Phagocytosis, cytokines, chemokines, complement, adhesion molecules (B)</p> Signup and view all the answers

What is the first step in the process of recruitment of cells to the site of infection?

<p>Reversible adherence (A)</p> Signup and view all the answers

What mediates the recruitment of cells to the site of infection?

<p>Chemokines and cell-adhesion molecules (C)</p> Signup and view all the answers

What is induced on the surface of infiltrating cells and the local blood vessel endothelium?

<p>Cell-adhesion molecules (B)</p> Signup and view all the answers

What family of molecules enables the first step of reversible adherence during the recruitment of cells to the site of infection?

<p>Selectins (B)</p> Signup and view all the answers

What appears on the endothelial cell surface within minutes of exposure to inflammatory mediators?

<p>P-selectin (A)</p> Signup and view all the answers

What type of adherence is enabled by selectins during the recruitment of cells to the site of infection?

<p>Reversible (B)</p> Signup and view all the answers

What is the final step in the process of recruitment of cells to the site of infection?

<p>Migration under the influence of chemokines (B)</p> Signup and view all the answers

What enables the cells to come out of the center of the blood vessel and interact with the endothelium at inflammatory sites?

<p>Dilated vessels and slower blood flow (D)</p> Signup and view all the answers

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