lecture 26- immunology

What is the primary reason for the rejection of transplanted tissue?

Which molecules are described as the most important alloantigens responsible for strong and rapid transplant rejection?

Why do most alloantigens differ among individuals?

How are host T cells (alloreactive T cells) described in relation to recognizing alloantigens?

What triggers the cellular and humoral immune responses in the recipient's immune system?

What is the prime target of graft vasculature for alloreactive antibodies?

What is the primary role of the adaptive immune system in responding to transplanted tissue?

Which immune system plays a critical but not primary role in responding to grafts?

In the direct pathway of alloreactive T cell activation, which cells present alloantigens directly to host T cells?

How do host and donor cells contribute to innate immune responses to grafts?

What is the main effector function engaged by alloreactive antibodies?

Which MHC molecules are most frequently recognized by alloantibodies?

What initiates ischemic damage in grafts?

Which immune responses are discussed in relation to the initial reactions of the recipient's immune system to transplanted tissue?

What is the process where host dendritic cells take up and process donor MHC molecules, presenting peptides to host T cells?

What is the primary focus of the lecture content on transplantation vocabulary?

Which term describes tissues or organs transplanted between genetically different individuals of the same species?

What do allogeneic antigens refer to in the context of transplantation?

How do host T cells recognize alloantigens through direct mechanisms?

What is the main outcome of molecules being recognized as foreign in an allograft?

What is the primary role of CD8+ cytotoxic T cells in transplant rejection?

How do CD4+ helper T cells contribute to tissue rejection in transplantation?

Which effector mechanisms target the vasculature of transplanted tissue?

What is the consequence of damage to the graft vasculature in a transplant?

What is the main outcome of sensitization in transplantation immunology?

What is the significance of MHC proteins in allorecognition?

How do effector CTLs contribute to graft rejection?

What is the outcome of direct recognition of alloantigens by host T cells?

Why does mismatch between donor and recipient MHC proteins increase the likelihood of graft rejection?

What role does direct presentation of alloantigens by donor dendritic cells to host T cells play in immunity?

What is the primary focus of transplantation immunology?

What distinguishes fundamental questions from clinical/applied questions in transplantation immunology?

In transplantation immunology, why is distinguishing between 'self' and 'foreign' important?

What area does clinical or applied questions in transplantation immunology primarily aim to address?

How do host T cells recognize alloantigens in the context of transplantation?

What is the main goal of understanding how the immune system recognizes transplanted tissues?

What role do alloreactive T cells play in recognizing alloantigens during transplantation?

Why is it important to understand recognition and rejection mechanisms in transplantation?

What is the main target of alloreactive B cells activation in transplantation immunology?

In transplantation immunology, which route involves donor dendritic cells presenting antigens directly to recipient T cells?

What is the primary role of recipient dendritic cells in the indirect pathway of alloantigen recognition?

Endothelial cells expressing Class I MHC are a prime target for what mechanism in transplantation immunology?

What is the key role of lymph nodes in the immune response in transplantation immunology?

Which mechanism do alloreactive antibodies engage through in response to allograft recognition?

In allograft rejection, what contributes significantly to the recognition of graft antigens?

What is the key difference between the direct and indirect pathways in transplantation immunology?

What is the primary role of CD8+ cytotoxic T cells in the rejection of transplanted tissue?

What effector functions do CD8+ cytotoxic T cells primarily engage in?

How do CD4+ helper T cells contribute to tissue damage in transplantation?

Which immune cells are primarily involved in recruiting complement proteins and contributing to tissue damage?

What is the main target of alloantibodies in the context of transplant rejection?

How do alloreactive B cells exacerbate tissue damage in transplant rejection?

Which cell type plays a crucial role in orchestrating an immune response against transplanted tissue?

In transplantation, what is the primary function of alloreactive T cells?

What is a significant consequence of damage to the vasculature of transplanted tissue?