24 Questions
Which factor affects drug deposition in the respiratory tract and systemic absorption of inhaled drugs?
Particle size
Which device is NOT a type of pulmonary drug delivery device?
Nasal spray
Which drug class is NOT available for pulmonary delivery?
Antifungals
What was inhaled through the stalk of a reed in the oldest known reference of therapeutic aerosol delivery?
Smoke of henbane plants
Which plant was used to make Potter’s Asthma Cigarettes?
Jimson weed (stramonium)
Which journal published an article by Stein and Thiel about aerosol delivery?
J. Aerosol Med. & Pulmonary Drug Delivery
What is the role of alveolar macrophages in drug deposition in the respiratory tract?
Clearing foreign particles
What is the main advantage of dry powder inhalers over pressurized metered-dose inhalers?
No propellants are needed
Which drug is NOT mentioned as available for pulmonary delivery?
Antihistamines
What is the purpose of spacer chambers in pulmonary drug delivery?
To slow down the aerosol particles
What is the main advantage of ultrasonic nebulizers over jet nebulizers?
They produce smaller particles
What is the main disadvantage of using anesthetic gases for pulmonary delivery?
Rapid systemic absorption
Which anti-cholinergic side effect is considered rare?
Coma
What is the preferred mode of delivery for drugs with a direct effect on airways?
Inhaled route
What is the only way for delivery of some drugs like cromolyn sodium and anticholinergic drugs?
Inhalation
Which receptors are located in the submucosal glands and smooth muscle cells of the conducting airways?
M3 receptors
What is the mechanism by which particles are deposited due to the force of gravity?
Sedimentation
What is the primary factor determining drug deposition in the respiratory tract?
Size of particles (MMAD)
What reduces the systemic absorption of inhaled drugs from the lungs?
All of the above
What is the most effective way to deliver antibiotics in patients with chronic pneumonia?
Inhalation
Which of the following is a life-threatening adverse effect for which physostigmine is used as a treatment?
Anti-cholinergic side effects
What is the role of a large-volume spacer in inhalation therapy?
To reduce systemic absorption of inhaled drugs
What is the primary location of β2-receptors in the respiratory tract?
Epithelium of the airways between the main bronchi and the terminal bronchioles
Which route of administration has a more rapid onset of action than the oral route?
Inhaled route
Test your knowledge of the pharmacology of inhalants with this quiz. Explore the mechanisms and factors affecting drug deposition in the respiratory tract, as well as the properties of pulmonary delivery devices. Identify available inhalant drugs and gain a comprehensive understanding of their systemic absorption.
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