Podcast
Questions and Answers
Which segment of the influenza virus genome codes for a shorter protein PB1-F2?
Which segment of the influenza virus genome codes for a shorter protein PB1-F2?
- Segment 2 (correct)
- Segment 4
- Segment 3
- Segment 6
What is the function of the non-structural protein NS1 in the influenza virus?
What is the function of the non-structural protein NS1 in the influenza virus?
- Interfering with host cell immune response (correct)
- Assisting in viral genome replication
- Regulating viral RNA transcription
- Facilitating viral envelope fusion with endosomal membrane
What facilitates fusion of viral envelope with the endosomal membrane in the influenza virus?
What facilitates fusion of viral envelope with the endosomal membrane in the influenza virus?
- Formation of HA trimers on virus surface
- Cleavage of HA by cellular proteases (correct)
- Presence of sialic acid residues
- Exposure of N-terminal of HA to the outside of the virion
Which part of the hemagglutinin (HA) protein binds to sialic acid on cell surface receptors?
Which part of the hemagglutinin (HA) protein binds to sialic acid on cell surface receptors?
Where does nucleocapsids enter for mRNA synthesis and RNA replication?
Where does nucleocapsids enter for mRNA synthesis and RNA replication?
Which protein is involved in 'pinching' the budding virions from the plasma membrane?
Which protein is involved in 'pinching' the budding virions from the plasma membrane?
What do inhibitors of cellular RNA synthesis block in influenza virus replication?
What do inhibitors of cellular RNA synthesis block in influenza virus replication?
What is the primary function of the viral protein M2?
What is the primary function of the viral protein M2?
What happens to each genomic RNA segment after transcription?
What happens to each genomic RNA segment after transcription?
What is a potential consequence of targeting M2 with antiviral drugs?
What is a potential consequence of targeting M2 with antiviral drugs?
What is the role of matrix protein (M1) and NS2 in relation to nucleocapsids?
What is the role of matrix protein (M1) and NS2 in relation to nucleocapsids?
What is required for orthomyxoviruses to replicate?
What is required for orthomyxoviruses to replicate?
What do capped cellular pre-mRNAs serve as in influenza virus replication?
What do capped cellular pre-mRNAs serve as in influenza virus replication?
Where do viral envelope proteins assemble before being incorporated into budding virions?
Where do viral envelope proteins assemble before being incorporated into budding virions?
What do viral mRNAs terminate in?
What do viral mRNAs terminate in?
What is the primary role of Uni-12 and Uni-13 sequences in the context of influenza virus?
What is the primary role of Uni-12 and Uni-13 sequences in the context of influenza virus?
What is the function of the non-structural protein NS1 in influenza virus?
What is the function of the non-structural protein NS1 in influenza virus?
What is the role of the viral protein M2 in the influenza virus life cycle?
What is the role of the viral protein M2 in the influenza virus life cycle?
What is the consequence of HA cleavage by cellular proteases?
What is the consequence of HA cleavage by cellular proteases?
What is the role of M2 in influenza virus replication?
What is the role of M2 in influenza virus replication?
What happens to each genomic RNA segment after transcription in influenza virus?
What happens to each genomic RNA segment after transcription in influenza virus?
What do inhibitors of cellular RNA synthesis block in influenza virus replication?
What do inhibitors of cellular RNA synthesis block in influenza virus replication?
What is the function of the non-structural protein NS1 in the influenza virus?
What is the function of the non-structural protein NS1 in the influenza virus?
What is a potential consequence of targeting M2 with antiviral drugs?
What is a potential consequence of targeting M2 with antiviral drugs?
What do capped cellular pre-mRNAs serve as in influenza virus replication?
What do capped cellular pre-mRNAs serve as in influenza virus replication?
Where does nucleocapsids enter for mRNA synthesis and RNA replication?
Where does nucleocapsids enter for mRNA synthesis and RNA replication?
Which part of the hemagglutinin (HA) protein binds to sialic acid on cell surface receptors?
Which part of the hemagglutinin (HA) protein binds to sialic acid on cell surface receptors?
What facilitates fusion of viral envelope with the endosomal membrane in influenza virus?
What facilitates fusion of viral envelope with the endosomal membrane in influenza virus?
What is the role of the non-structural protein NS1 in influenza virus?
What is the role of the non-structural protein NS1 in influenza virus?
Which segment of the influenza virus genome codes for a shorter protein PB1-F2?
Which segment of the influenza virus genome codes for a shorter protein PB1-F2?
What facilitates fusion of viral envelope with the endosomal membrane in the influenza virus?
What facilitates fusion of viral envelope with the endosomal membrane in the influenza virus?
What is the primary role of Uni-12 and Uni-13 sequences in the context of influenza virus?
What is the primary role of Uni-12 and Uni-13 sequences in the context of influenza virus?
What is the role of M2 in influenza virus replication?
What is the role of M2 in influenza virus replication?
What is the consequence of targeting M2 with antiviral drugs?
What is the consequence of targeting M2 with antiviral drugs?
What do capped cellular pre-mRNAs serve as in influenza virus replication?
What do capped cellular pre-mRNAs serve as in influenza virus replication?
What do inhibitors of cellular RNA synthesis block in influenza virus replication?
What do inhibitors of cellular RNA synthesis block in influenza virus replication?
Where do viral envelope proteins assemble before being incorporated into budding virions?
Where do viral envelope proteins assemble before being incorporated into budding virions?
What is required for orthomyxoviruses to replicate?
What is required for orthomyxoviruses to replicate?
What happens to each genomic RNA segment after transcription?
What happens to each genomic RNA segment after transcription?
What is the function of the non-structural protein NS1 in influenza virus?
What is the function of the non-structural protein NS1 in influenza virus?
What is the primary function of the viral protein M2?
What is the primary function of the viral protein M2?
Which part of the hemagglutinin (HA) protein binds to sialic acid on cell surface receptors?
Which part of the hemagglutinin (HA) protein binds to sialic acid on cell surface receptors?
What is a potential consequence of targeting M2 with antiviral drugs?
What is a potential consequence of targeting M2 with antiviral drugs?
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Study Notes
Influenza Virus Replication and Antiviral Targets
- The viral protein M2 forms an ion channel that allows protons to enter the virus, weakening the interaction of M1 with nucleocapsids
- M2 is a target for antiviral drugs, but drug resistance can occur due to viral mutations
- M2 is a relatively small protein that forms a tetramer and creates a small pore in the virus envelope
- Nucleocapsids enter the nucleus where mRNA synthesis and RNA replication occur
- Orthomyxoviruses replicate in the nucleus, requiring complex machinery for viral replication
- Nucleocapsids are exported from the nucleus in a complex with matrix protein (M1) and NS2
- Capped cellular pre-mRNAs are used as primers for synthesis of viral mRNAs
- Inhibitors of cellular RNA synthesis block the replication of influenza virus
- Each genomic RNA segment contains a stretch of poly-U and viral mRNAs terminate in poly(A) tail
- Transcription generates a set of 8 viral mRNAs, with segments 1-6 exported directly to the cytoplasm
- Viral envelope proteins transverse through the ER and Golgi to assemble in the plasma membrane
- M2 is involved in "pinching" the budding virions from the plasma membrane
Influenza Virus Replication and Antiviral Targets
- The viral protein M2 forms an ion channel that allows protons to enter the virus, weakening the interaction of M1 with nucleocapsids
- M2 is a target for antiviral drugs, but drug resistance can occur due to viral mutations
- M2 is a relatively small protein that forms a tetramer and creates a small pore in the virus envelope
- Nucleocapsids enter the nucleus where mRNA synthesis and RNA replication occur
- Orthomyxoviruses replicate in the nucleus, requiring complex machinery for viral replication
- Nucleocapsids are exported from the nucleus in a complex with matrix protein (M1) and NS2
- Capped cellular pre-mRNAs are used as primers for synthesis of viral mRNAs
- Inhibitors of cellular RNA synthesis block the replication of influenza virus
- Each genomic RNA segment contains a stretch of poly-U and viral mRNAs terminate in poly(A) tail
- Transcription generates a set of 8 viral mRNAs, with segments 1-6 exported directly to the cytoplasm
- Viral envelope proteins transverse through the ER and Golgi to assemble in the plasma membrane
- M2 is involved in "pinching" the budding virions from the plasma membrane
Influenza Virus Replication and Antiviral Targets
- The viral protein M2 forms an ion channel that allows protons to enter the virus, weakening the interaction of M1 with nucleocapsids
- M2 is a target for antiviral drugs, but drug resistance can occur due to viral mutations
- M2 is a relatively small protein that forms a tetramer and creates a small pore in the virus envelope
- Nucleocapsids enter the nucleus where mRNA synthesis and RNA replication occur
- Orthomyxoviruses replicate in the nucleus, requiring complex machinery for viral replication
- Nucleocapsids are exported from the nucleus in a complex with matrix protein (M1) and NS2
- Capped cellular pre-mRNAs are used as primers for synthesis of viral mRNAs
- Inhibitors of cellular RNA synthesis block the replication of influenza virus
- Each genomic RNA segment contains a stretch of poly-U and viral mRNAs terminate in poly(A) tail
- Transcription generates a set of 8 viral mRNAs, with segments 1-6 exported directly to the cytoplasm
- Viral envelope proteins transverse through the ER and Golgi to assemble in the plasma membrane
- M2 is involved in "pinching" the budding virions from the plasma membrane
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